Is vitamin D a determinant of muscle mass and strength?

Journal of Bone and Mineral Research

Volumn 26, Issue 12, 2011, Pages 2860-2871

  Marantes, Isabel ^a,b   Achenbach, Sara J ^a   Atkinson, Elizabeth J ^a   Khosla, Sundeep ^c   Melton III, L Joseph ^a,c   Amin, Shreyasee ^a,c  

^a Mayo Clinic   (United States)

^b Faculty of Medicine of Oporto   (Portugal)

^c MAYO CLINIC   (United States)

Author keywords

1,25 DIHYDROXYVITAMIN D; 25 HYDROXYVITAMIN D; MUSCLE; MUSCLE MASS; MUSCLE STRENGTH; PTH; VITAMIN D

Indexed keywords

25 HYDROXYVITAMIN D; CALCITRIOL; PARATHYROID HORMONE;

ADULT; AGED; ARTICLE; BODY FAT; COMMUNITY SAMPLE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; GRIP STRENGTH; GROUPS BY AGE; HUMAN; HUMAN EXPERIMENT; KNEE; MALE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE MASS; MUSCLE STRENGTH; NORMAL HUMAN; PARATHYROID HORMONE BLOOD LEVEL; PHYSICAL ACTIVITY; SEASONAL VARIATION; SKELETAL MUSCLE; VITAMIN BLOOD LEVEL;

ADULT; AGED; AGED, 80 AND OVER; BIOMECHANICS; FEMALE; HAND STRENGTH; HUMANS; ISOMETRIC CONTRACTION; KNEE; MALE; MIDDLE AGED; MINNESOTA; MUSCLE STRENGTH; MUSCLES; ORGAN SIZE; PARATHYROID HORMONE; VITAMIN D; YOUNG ADULT;

EID: 81855193723     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.510     Document Type: Article

References (63)

1. Latham NK, Anderson CS, Reid IR,. Effects of vitamin D supplementation on strength, physical performance, and falls in older persons: a systematic review. J Am Geriatr Soc. 2003; 51 (9): 1219-26. (Pubitemid 37093570)
2. Annweiler C, Schott AM, Berrut G, Fantino B, Beauchet O,. Vitamin D-related changes in physical performance: a systematic review. J Nutr Health Aging. 2009; 13 (10): 893-8.
3. Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J,. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ. 2009; 339: b3692.
4. Bischoff-Ferrari HA, Dietrich T, Orav EJ, Hu FB, Zhang Y, Karlson EW, Dawson-Hughes B,. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or = 60 y. Am J Clin Nutr. 2004; 80 (3): 752-8. (Pubitemid 41115542)
5. Pfeifer M, Begerow B, Minne HW, Abrams C, Nachtigall D, Hansen C,. Effects of a short-term vitamin D and calcium supplementation on body sway and secondary hyperparathyroidism in elderly women. J Bone Miner Res. 2000; 15 (6): 1113-8. (Pubitemid 30350073)
6. Bischoff HA, Borchers M, Gudat F, Duermueller U, Theiler R, Stahelin HB, Dick W,. In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J. 2001; 33 (1): 19-24. (Pubitemid 32368054)
7. Grundberg E, Brandstrom H, Ribom EL, Ljunggren O, Mallmin H, Kindmark A,. Genetic variation in the human vitamin D receptor is associated with muscle strength, fat mass and body weight in Swedish women. Eur J Endocrinol. 2004; 150 (3): 323-8. (Pubitemid 38443782)
8. Roth SM, Zmuda JM, Cauley JA, Shea PR, Ferrell RE,. Vitamin D receptor genotype is associated with fat-free mass and sarcopenia in elderly men. J Gerontol A Biol Sci Med Sci. 2004; 59 (1): 10-5. (Pubitemid 38082824)
9. Windelinckx A, De Mars G, Beunen G, Aerssens J, Delecluse C, Lefevre J, Thomis MA,. Polymorphisms in the vitamin D receptor gene are associated with muscle strength in men and women. Osteoporos Int. 2007; 18 (9): 1235-42. (Pubitemid 47300281)
10. Geusens P, Vandevyver C, Vanhoof J, Cassiman JJ, Boonen S, Raus J,. Quadriceps and grip strength are related to vitamin D receptor genotype in elderly nonobese women. J Bone Miner Res. 1997; 12 (12): 2082-8. (Pubitemid 27524485)
11. Glerup H, Mikkelsen K, Poulsen L, Hass E, Overbeck S, Andersen H, Charles P, Eriksen EF,. Hypovitaminosis D myopathy without biochemical signs of osteomalacic bone involvement. Calcif Tissue Int. 2000; 66 (6): 419-24. (Pubitemid 30368371)
12. Schott GD, Wills MR,. Muscle weakness in osteomalacia. Lancet. 1976; 1 (7960): 626-9.
13. Grady D, Halloran B, Cummings S, Leveille S, Wells L, Black D, Byl N,. 1,25-Dihydroxyvitamin D3 and muscle strength in the elderly: a randomized controlled trial. J Clin Endocrinol Metab. 1991; 73 (5): 1111-7. (Pubitemid 21901155)
14. Kenny AM, Biskup B, Robbins B, Marcella G, Burleson JA,. Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men. J Am Geriatr Soc. 2003; 51 (12): 1762-7. (Pubitemid 37543363)
15. Pfeifer M, Begerow B, Minne HW, Suppan K, Fahrleitner-Pammer A, Dobnig H,. Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int. 2009; 20 (2): 315-22.
16. Bischoff HA, Stahelin HB, Dick W, Akos R, Knecht M, Salis C, Nebiker M, Theiler R, Pfeifer M, Begerow B, Lew RA, Conzelmann M,. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res. 2003; 18 (2): 343-51. (Pubitemid 36125927)
17. Latham NK, Anderson CS, Lee A, Bennett DA, Moseley A, Cameron ID,. A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the Frailty Interventions Trial in Elderly Subjects (FITNESS). J Am Geriatr Soc. 2003; 51 (3): 291-9. (Pubitemid 36348889)
18. Dhesi JK, Jackson SH, Bearne LM, Moniz C, Hurley MV, Swift CG, Allain TJ,. Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing. 2004; 33 (6): 589-95. (Pubitemid 39504292)
19. Verhaar HJ, Samson MM, Jansen PA, de Vreede PL, Manten JW, Duursma SA,. Muscle strength, functional mobility and vitamin D in older women. Aging (Milano). 2000; 12 (6): 455-60. (Pubitemid 32095602)
20. Johnson KR, Jobber J, Stonawski BJ,. Prophylactic vitamin D in the elderly. Age Ageing. 1980; 9 (2): 121-7. (Pubitemid 10014434)
21. Honkanen R, Alhava E, Parviainen M, Talasniemi S, Monkkonen R,. The necessity and safety of calcium and vitamin D in the elderly. J Am Geriatr Soc. 1990; 38 (8): 862-6. (Pubitemid 20267744)
22. Songpatanasilp T, Chailurkit LO, Nichachotsalid A, Chantarasorn M,. Combination of alfacalcidol with calcium can improve quadriceps muscle strength in elderly ambulatory Thai women who have hypovitaminosis D: a randomized controlled trial. J Med Assoc Thai. 2009; 92 (Suppl5): S30-41.
23. Moreira-Pfrimer LD, Pedrosa MA, Teixeira L, Lazaretti-Castro M,. Treatment of vitamin D deficiency increases lower limb muscle strength in institutionalized older people independently of regular physical activity: a randomized double-blind controlled trial. Ann Nutr Metab. 2009; 54 (4): 291-300.
24. Janssen HC, Samson MM, Verhaar HJ,. Muscle strength and mobility in vitamin D-insufficient female geriatric patients: a randomized controlled trial on vitamin D and calcium supplementation. Aging Clin Exp Res. 2010; 22 (1): 78-84.
25. Zhu K, Austin N, Devine A, Bruce D, Prince RL,. A randomized controlled trial of the effects of vitamin D on muscle strength and mobility in older women with vitamin D insufficiency. J Am Geriatr Soc. 2010; 58 (11): 2063-8.
26. Ceglia L, Chiu GR, Harris SS, Araujo AB,. Serum 25-hydroxyvitamin D concentration and physical function in adult men. Clin Endocrinol (Oxf). 2011; 74 (3): 370-6.
27. Bischoff HA, Stahelin HB, Urscheler N, Ehrsam R, Vonthein R, Perrig-Chiello P, Tyndall A, Theiler R,. Muscle strength in the elderly: its relation to vitamin D metabolites. Arch Phys Med Rehabil. 1999; 80 (1): 54-8. (Pubitemid 29035822)
28. Zamboni M, Zoico E, Tosoni P, Zivelonghi A, Bortolani A, Maggi S, Di Francesco V, Bosello O,. Relation between vitamin D, physical performance, and disability in elderly persons. J Gerontol A Biol Sci Med Sci. 2002; 57 (1): M7-11. (Pubitemid 34074440)
29. Boonen S, Lysens R, Verbeke G, Joosten E, Dejaeger E, Pelemans W, Flamaing J, Bouillon R,. Relationship between age-associated endocrine deficiencies and muscle function in elderly women: a cross-sectional study. Age Ageing. 1998; 27 (4): 449-54. (Pubitemid 28404608)
30. Houston DK, Cesari M, Ferrucci L, Cherubini A, Maggio D, Bartali B, Johnson MA, Schwartz GG, Kritchevsky SB,. Association between vitamin D status and physical performance: the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2007; 62 (4): 440-6. (Pubitemid 47065713)
31. Gerdhem P, Ringsberg KA, Obrant KJ, Akesson K,. Association between 25-hydroxy vitamin D levels, physical activity, muscle strength and fractures in the prospective population-based OPRA Study of Elderly Women. Osteoporos Int. 2005; 16 (11): 1425-31. (Pubitemid 41534648)
32. Mowe M, Haug E, Bohmer T,. Low serum calcidiol concentration in older adults with reduced muscular function. J Am Geriatr Soc. 1999; 47 (2): 220-6. (Pubitemid 29082723)
33. Dhesi JK, Bearne LM, Moniz C, Hurley MV, Jackson SH, Swift CG, Allain TJ,. Neuromuscular and psychomotor function in elderly subjects who fall and the relationship with vitamin D status. J Bone Miner Res. 2002; 17 (5): 891-7. (Pubitemid 34441906)
34. Pfeifer M, Begerow B, Minne HW, Schlotthauer T, Pospeschill M, Scholz M, Lazarescu AD, Pollahne W,. Vitamin D status, trunk muscle strength, body sway, falls, and fractures among 237 postmenopausal women with osteoporosis. Exp Clin Endocrinol Diabetes. 2001; 109 (2): 87-92. (Pubitemid 32294575)
35. Rinaldi I, Setiati S, Oemardi M, Aries W, Tamin TZ,. Correlation between serum vitamin D (25(OH)D) concentration and quadriceps femoris muscle strength in Indonesian elderly women living in three nursing homes. Acta Med Indones. 2007; 39 (3): 107-11.
36. Stewart JW, Alekel DL, Ritland LM, Van Loan M, Gertz E, Genschel U,. Serum 25-hydroxyvitamin D is related to indicators of overall physical fitness in healthy postmenopausal women. Menopause. 2009; 16 (6): 1093-101.
37. Inderjeeth CA, Glennon D, Petta A, Soderstrom J, Boyatzis I, Tapper J,. Vitamin D and muscle strength in patients with previous fractures. N Z Med J. 2007; 120 (1262): U2730.
38. Iannuzzi-Sucich M, Prestwood KM, Kenny AM,. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci. 2002; 57 (12): M772-7. (Pubitemid 35470952)
39. Shaunak S, Ang L, Colston K, Patel S, Bland M, Maxwell JD,. Muscle strength in healthy white and Asian subjects: the relationship of quadriceps maximum voluntary contraction to age, sex, body build and vitamin D. Clin Sci (Lond). 1987; 73 (5): 541-6. (Pubitemid 18019704)
40. Verreault R, Semba RD, Volpato S, Ferrucci L, Fried LP, Guralnik JM,. Low serum vitamin d does not predict new disability or loss of muscle strength in older women. J Am Geriatr Soc. 2002; 50 (5): 912-7. (Pubitemid 34496690)
41. Visser M, Deeg DJ, Lips P,. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab. 2003; 88 (12): 5766-72. (Pubitemid 38033048)
42. Gilsanz V, Kremer A, Mo AO, Wren TA, Kremer R,. Vitamin D status and its relation to muscle mass and muscle fat in young women. J Clin Endocrinol Metab. 2010; 95 (4): 1595-601.
43. Annweiler C, Beauchet O, Berrut G, Fantino B, Bonnefoy M, Herrmann FR, Schott AM,. Is there an association between serum 25-hydroxyvitamin D concentration and muscle strength among older women? Results from baseline assessment of the EPIDOS study. J Nutr Health Aging. 2009; 13 (2): 90-5.
44. Holick MF,. Vitamin D deficiency. N Engl J Med. 2007; 357 (3): 266-81.
45. Riggs BL, Melton Iii LJ 3rd, Robb RA, Camp JJ, Atkinson EJ, Peterson JM, Rouleau PA, McCollough CH, Bouxsein ML, Khosla S,. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res. 2004; 19 (12): 1945-54. (Pubitemid 41103408)
46. Melton LJ 3rd., History of the Rochester Epidemiology Project. Mayo Clin Proc. 1996; 71 (3): 266-74.
47. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002; 39 (2 Suppl 1): S1-266.
48. Ainsworth BE, Haskell WL, Leon AS, Jacobs DR Jr, Montoye HJ, Sallis JF, Paffenbarger RS Jr., Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc. 1993; 25 (1): 71-80. (Pubitemid 23027685)
49. Wang ZM, Visser M, Ma R, Baumgartner RN, Kotler D, Gallagher D, Heymsfield SB,. Skeletal muscle mass: evaluation of neutron activation and dual-energy X-ray absorptiometry methods. J Appl Physiol. 1996; 80 (3): 824-31.
50. Sale DG,. Testing of strength and power. In:, MacDougall JD, Wenger HA, Green HJ, editors. Physiological testing of the high-performance athlete. 2nd edition. Champaign, IL, USA: Human Kinetics; 1991. pp 21-106.
51. Chinappen-Horsley U, Blake GM, Fogelman I, Spector TD,. A method for determining skeletal lengths from DXA images. BMC Musculoskelet Disord. 2007; 8: 113.
52. Folland JP, Mc Cauley TM, Williams AG,. Allometric scaling of strength measurements to body size. Eur J Appl Physiol. 2008; 102 (6): 739-45.
53. Jaric S,. Muscle strength testing: use of normalisation for body size. Sports Med. 2002; 32 (10): 615-31.
54. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, Kovacs CS, Mayne ST, Rosen CJ, Shapses SA,. The 2011 report on dietary reference intakes for calcium and vitamin d from the institute of medicine: what clinicians need to know. J Clin Endocrinol Metab. 2011; 96 (1): 53-8.
55. Stockton KA, Mengersen K, Paratz JD, Kandiah D, Bennell KL,. Effect of vitamin D supplementation on muscle strength: a systematic review and meta-analysis. Osteoporos Int. 2011; 22 (3): 859-71.
56. Wang Y, Deluca HF,. Is the vitamin D receptor found in muscle? Endocrinology. 2011; 152 (2): 354-63.
57. Gloth FM 3rd, Smith CE, Hollis BW, Tobin JD,. Functional improvement with vitamin D replenishment in a cohort of frail, vitamin D-deficient older people. J Am Geriatr Soc. 1995; 43 (11): 1269-71.
58. Ensrud KE, Ewing SK, Fredman L, Hochberg MC, Cauley JA, Hillier TA, Cummings SR, Yaffe K, Cawthon PM;, Study of Osteoporotic Fractures Research Group. Circulating 25-hydroxyvitamin D levels and frailty status in older women. J Clin Endocrinol Metab. 2010; 95 (12): 5266-73.
59. McGrath JJ, Feron FP, Burne TH, Mackay-Sim A, Eyles DW,. Vitamin D3-implications for brain development. J Steroid Biochem Mol Biol. 2004; 89-90 (1-5): 557-60.
60. Prufer K, Veenstra TD, Jirikowski GF, Kumar R,. Distribution of 1,25-dihydroxyvitamin D3 receptor immunoreactivity in the rat brain and spinal cord. J Chem Neuroanat. 1999; 16 (2): 135-45. (Pubitemid 29155499)
61. Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ,. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat. 2005; 29 (1): 21-30. (Pubitemid 39602785)
62. Neveu I, Naveilhan P, Jehan F, Baudet C, Wion D, De Luca HF, Brachet P,. 1,25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells. Brain Res Mol Brain Res. 1994; 24 (1-4): 70-6.
63. Annweiler C, Schott AM, Montero-Odasso M, Berrut G, Fantino B, Herrmann FR, Beauchet O,. Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: the EPIDOS study. J Bone Miner Res. 2010; 25 (8): 1858-66.