Apocynin, a plant-derived drug, might be useful in the treatment of myocardial ischemia reperfusion injury in rat hearts

European Journal of Inflammation

Volumn 9, Issue 2, 2011, Pages 157-168

  Di Paola, R ^a   Mazzon, E ^a   Paterniti, I ^b   Impellizzeri, D ^b   Bramanti, P ^a   Cuzzocrea, Salvatore ^a,b  

^a IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Apoptosis; Myocardial ischemia reperfusion; NF kB expression; Nitrosative stress; Pro inflammatory cytokines

Indexed keywords

3 NITROTYROSINE; APOCYNIN; CYTOKINE; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; PADGEM PROTEIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN BAX; PROTEIN BCL 2; REACTIVE NITROGEN SPECIES; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HEART MUSCLE ISCHEMIA; HISTOLOGY; MALE; NEUTROPHIL; NICK END LABELING; NONHUMAN; PICRORHIZA KURROA; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

EID: 81855191559     PISSN: 1721727X     EISSN: None     Source Type: Journal    
DOI: 10.1177/1721727X1100900210     Document Type: Article

References (25)

1. Li C, Jackson RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol 2002; 282:227-41.
2. Johnson DK, Schillinger KJ, Kwait DM, Hughes CV. Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols. Endothelium 2002; 9:191-203. (Pubitemid 35021589)
3. Meyer JW, Holland JA, Ziegler LM, Chang MM. Identification of a functional leukocyte-type NADPH oxidase in human endothelial cells: a potential atherogenic source of reactive oxygen species. Endothelium 1999; 7:11-22. (Pubitemid 29481520)
4. Zhang Y, Chan MM, Andrews MC, Mori TA. Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat. Am J Hypertens 2005; 18:910-16. (Pubitemid 41040260)
5. Heumuller S, Wind S, Barbosa-Sicard E, Schmidt HH. Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant. Hypertension 2008; 51:211-17. (Pubitemid 351159930)
6. Dodd-o JM, Welsh LE, Salazar JD, Walinsky PL. Effect of NADPH oxidase inhibition on cardiopulmonary bypass-induced lung injury. Am J Physiol Heart Circ Physiol 2004; 287:927-36.
7. Samsamshariat SA, Movahed MR. High rate of right ventricular infarction after ligation of mid left anterior descending artery in rats. Cardiovasc Revasc Med 2005; 6:21-23. (Pubitemid 41262615)
8. Wayman NS, McDonald MC, Chatterjee PK, Thiemermann C. Models of coronary artery occlusion and reperfusion for the discovery of novel antiischemic and antiinflammatory drugs for the heart. Met Mol Biol (Clifton, NJ 2003; 225:99-108.
9. Kimura H, Liu S, Yamada S, Uchida K. Rapid increase in serum lipid peroxide 4-hydroxynonenal (HNE) through monocyte NADPH oxidase in early endo-toxemia. Free Rad Res 2005; 39:845-51. (Pubitemid 40975077)
10. Wang Q, Tompkins KD, Simonyi A, Korthuis RJ. Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus. Brain Res 2006; 1090:182-89. (Pubitemid 43817927)
11. Cuzzocrea S, Di Paola R, Mazzon E, Cortes U. PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion. Faseb J 2005; 19:558-66. (Pubitemid 40471247)
12. Li C, Kao RL, Ha T, Kelley J. Early activation of IKKbeta during in vivo myocardial ischemia. Am J Physiol Heart Circ Physiol 2001; 280:1264-71.
13. Chandrasekar B, Freeman GL. Induction of nuclear factor kappaB and activation protein 1 in postischemic myocardium. FEBS letters 1997; 401:30-34. (Pubitemid 27051252)
14. Nichols TC. NF-kappaB and reperfusion injury. Drug News Perspect 2004; 17:99-104.
15. Deten A, Volz HC, Briest W, Zimmer HG. Cardiac cytokine expression is upregulated in the acute phase after myocardial infarction. Experimental studies in rats. Cardiovasc Res 2002; 55:329-40. (Pubitemid 34775283)
16. Weller A, Isenmann S, Vestweber D. Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha. J Biol Chem 1992; 267:15176-83.
17. Ma XL, Weyrich AS, Lefer DJ, Buerke M. Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium. Circulation 1993; 88:649-58. (Pubitemid 23228066)
18. Wang P, Zweier JL. Measurement of nitric oxide and peroxynitrite generation in the postischemic heart. Evidence for peroxynitrite-mediated reperfusion injury. J Biol Chem 1996; 271:29223-30. (Pubitemid 26382634)
19. Ischiropoulos H, Zhu L, Chen J, Tsai M. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase. Arch Biochem Biophys 1992; 298:431-37.
20. Zhang Y, Bissing JW, Xu L, Ryan AJ, et al. Nitric oxide synthase inhibitors decrease coronary sinus-free radical concentration and ameliorate myocardial stunning in an ischemia-reperfusion model. J Am Coll Cardiol 2001; 38:546-54. (Pubitemid 32721787)
21. Szabo C, Zingarelli B, O'Connor M, Salzman AL. DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite. P Natl Acad Sci USA 1996; 93:1753-58. (Pubitemid 26079829)
22. Galang N, Sasaki H, Maulik N. Apoptotic cell death during ischemia/reperfusion and its attenuation by antioxidant therapy. Toxicology 2000; 148:111-18. (Pubitemid 30621350)
23. Antonsson B, Martinou JC. The Bcl-2 protein family. Exp Cell Res 2000; 256:50-57. (Pubitemid 30211166)
24. Misao J, Hayakawa Y, Ohno M, Kato S. Expression of bcl-2 protein, an inhibitor of apoptosis, and Bax, an accelerator of apoptosis, in ventricular myocytes of human hearts with myocardial infarction. Circulation 1996; 94:1506-12. (Pubitemid 26320251)
25. Tang XN, Cairns B, Cairns N, Yenari MA. Apocynin improves outcome in experimental stroke with a narrow dose range. Neuroscience 2008; 154:556-62.