(WO2011057959) Indole and indazole derivatives as glycogen synthase activators: A patent evaluation

Expert Opinion on Therapeutic Patents

Volumn 21, Issue 12, 2011, Pages 1925-1929

  Skaltsounis, Alexios Leandros ^a   Gaboriaud Kolar, Nicolas ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Biaryloxymethylarene carboxylic acid; Biological evaluation; Glycogen synthase; Indazole; Indole; Patent evaluation; Type 2 diabetes mellitus

Indexed keywords

CARBOXYLIC ACID; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; GLYCOGEN SYNTHASE; INDAZOLE DERIVATIVE; INDOLE DERIVATIVE; METFORMIN; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; WO2011057959;

ARTICLE; BIOCOMPATIBILITY; CHEMISTRY; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; GLYCOGEN SYNTHESIS; HYPOGLYCEMIA; IN VITRO STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PH; SUZUKI REACTION; WEIGHT GAIN;

ANIMALS; DIABETES MELLITUS, TYPE 2; DRUG DESIGN; ENZYME ACTIVATION; ENZYME ACTIVATORS; GLYCOGEN SYNTHASE; HUMANS; HYPOGLYCEMIC AGENTS; INDAZOLES; INDOLES; MOLECULAR STRUCTURE; PATENTS AS TOPIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 81855190658     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2011.625406     Document Type: Article

References (12)

1. De Fronzo RA. Pathogenesis of type 2 diabetes: implications of metformin. Drugs 1999;21(Suppl 1):29-30
2. Rendell M. The role of sulphonylureas in the management of type 2 diabetes mellitus. Drugs 2004;64(12):1339-58
3. Saltiel AR, Olefsky JM. Thiazolidinediones in the treatment of insulin resistance and type 2 diabetes. Diabetes 1996;45(12):1661-9
4. Kelley DE, Bidot P, Freedman Z, et al. Efficacy and safety of acarbose in insulin-treated patients with type 2 diabetes. Diabetes Care 1998;21(12):2056-61
5. Krssak M, Brehm A, Bernroider E, et al. Alterations in postprandrial hepatic glycogen metabolism in type 2 diabetes. Diabetes 2004;53(12):3048-56
6. Hoffmann-LaRoche. Indole and indazole derivatives as glycogen synthase activators. WO057959; 2011
7. Hoffmann-LaRoche. Biaryloxymethylarene carboxylic acids as glycogen synthase activators. US0266856; 2004
8. Hoffmann-LaRoche. biaryloxymethylarene carboxylic acids as glycogen synthase activators. US0255198; 2008
9. Hoffmann-LaRoche. Biaryloxymethylarene carboylic acids. EP1819691; 2006
10. Bolin DR, Qian Y, Chhabilbhai Takkar K, et al. Biphenylcarboxylic acids and bioisosteres as glycogen synthase activators. US0118322; 2011
11. Huwe A, Mazitschek R, Giannis A. Small molecules as Inhibitors of cyclin-dependent kinases. Angew Chem Int Ed 2003;42:2122-38
12. Li R, Stafford JA. Kinase inhibitors drugs. Wiley: 2009