Brain ischemia and hypometabolism treated by ozone therapy

Forschende Komplementarmedizin

Volumn 18, Issue 5, 2011, Pages 283-287

  Clavo, Bernardino ^a,b,e,g   Suarez, Gerardo ^a,b,e   Aguilar, Yolanda ^d   Gutierrez, Dominga ^a,b,e   Ponce, Pedro ^c   Cubero, Alberto ^a   Robaina, Francisco ^a   Carreras, Jose L ^f  

^a Dr Negrin University Hospital   (Spain)

^b Chronic Pain Unit   (Spain)

^c Department of Neuro Radiology ^*  (Spain)

^d DIMEC Center   (Spain)

^e Madrid Spain   (Spain)

^f FOCUSCAN PET Institute   (Spain)

^g Grupo de Investigacion Clinica en Oncologia Radioterapica GICOR   (Spain)

Author keywords

Leukoencephalopathy; Ozone therapy; PET; Positron emission tomography; Radiation induced brain injury; Radiosurgery; Side effects; Single photon emission computed tomography; SPECT; Stroke

Indexed keywords

OZONE;

AGED; ARTICLE; BLOOD FLOW; BRAIN; BRAIN ISCHEMIA; CASE REPORT; DRUG EFFECT; FEMALE; HUMAN; METABOLISM; POSITRON EMISSION TOMOGRAPHY; TREATMENT OUTCOME; VASCULARIZATION;

AGED; BRAIN; BRAIN ISCHEMIA; FEMALE; HUMANS; OZONE; POSITRON-EMISSION TOMOGRAPHY; REGIONAL BLOOD FLOW; TREATMENT OUTCOME;

EID: 81855166759     PISSN: 16614119     EISSN: 16614127     Source Type: Journal    
DOI: 10.1159/000333795     Document Type: Article

References (26)

1. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J: Heart disease and stroke statistics -2010 update: A report from the American Heart Association. Circulation 2010;121:e96-e215.
2. Bocci VA: Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006;37: 425-435.
3. Ajamieh HH, Menendez S, Martinez-Sanchez G, Candelario-Jalil E, Re L, Giuliani A, Fernandez OS: Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia-reperfusion. Liver Int 2004;24:55-62. (Pubitemid 38351214)
4. Chen H, Xing B, Liu X, Zhan B, Zhou J, Zhu H, Chen Z: Ozone oxidative preconditioning protects the rat kidney from reperfusion injury: The role of nitric oxide. J Surg Res 2008;149:287-295.
5. Verrazzo G, Coppola L, Luongo C, Sammartino A, Giunta R, Grassia A, Ragone R, Tirelli A: Hyperbaric oxygen, oxygen-ozone therapy, and rheologic parameters of blood in patients with peripheral occlusive arterial disease. Undersea Hyperb Med 1995;22:17-22.
6. Valacchi G, Bocci V: Studies on the biological effects of ozone: 11. release of factors from human endothelial cells. Mediators Inflamm 2000;9:271-276. (Pubitemid 32096980)
7. Giunta R, Coppola A, Luongo C, Sammartino A, Guastafierro S, Grassia A, Giunta L, Mascolo L, Tirelli A, Coppola L: Ozonized autohemotransfusion improves hemorheological parameters and oxygen delivery to tissues in patients with peripheral occlusive arterial disease. Ann Hematol 2001;80: 745-748. (Pubitemid 34041432)
8. Clavo B, Catala L, Perez JL, Rodriguez V, Robaina F: Ozone therapy on cerebral blood flow: A preliminary report. Evid Based Complement Alternat Med 2004;1:315-319.
9. Clavo B, Perez JL, Lopez L, Suarez G, Lloret M, Rodriguez V, Macias D, Santana M, Morera J, Fiuza D, Robaina F, Gunderoth M: Effect of ozone therapy on muscle oxygenation. J Altern Complement Med 2003;9:251-256. (Pubitemid 36506121)
10. Clavo B, Robaina FJ, Gutierrez D, Lopez L, Suarez G, Carames MA, Rodriguez MA, Lloret M, Orihuela I, Herrero M, Macias D, Jorge IJ, Ceballos D, Febles G, Cruz F, Hernandez MA: Historia y experiencia con ozonoterapia en el hospital universitario dr. Negrin de las palmas. Rev Soc Esp Dolor 2005;12:53-60.
11. Clavo B, Gutierrez D, Martin D, Suarez G, Hernandez MA, Robaina F: Intravesical ozone therapy for progressive radiation-induced hematuria. J Altern Complement Med 2005;11:539-541. (Pubitemid 40994592)
12. Clavo B, Gutierrez D, Ceballos D, Rovira G, Suarez G, Lopez L, Pinar B, Cabezon A, Rabano AI, Oliva E, Fiuza MD: Treatment of refractory radiation-induced hemorrhagic proctitis with ozone therapy. Radiother Oncol 2010;96:379.
13. Loewen SC, Anderson BA: Predictors of stroke outcome using objective measurement scales. Stroke 1990;21:78-81. (Pubitemid 20052534)
14. Shaw EG, Robbins ME: The management of radiation-induced brain injury; in Small WJ, Woloschak GE (eds): Radiation Toxicity: A Practical Guide. New York, Springer, 2008, pp 7-22.
15. The International Stroke Trial (IST): A randomised trial of aspirin, subcutaneous heparin, both, or neither among 19,435 patients with acute ischaemic stroke. International Stroke Trial Collaborative Group. Lancet 1997;349:1569-1581.
16. Hacke W, Donnan G, Fieschi C, Kaste M, von Kummer R, Broderick JP, Brott T, Frankel M, Grotta JC, Haley EC Jr, Kwiatkowski T, Levine SR, Lewandowski C, Lu M, Lyden P, Marler JR, Patel S, Tilley BC, Albers G, Bluhmki E, Wilhelm M, Hamilton S: Association of outcome with early stroke treatment: Pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet 2004;363:768-774.
17. Glantz MJ, Burger PC, Friedman AH, Radtke RA, Massey EW, Schold SC Jr: Treatment of radiationinduced nervous system injury with heparin and warfarin. Neurology 1994;44:2020-2027. (Pubitemid 24349499)
18. Chuba PJ, Aronin P, Bhambhani K, Eichenhorn M, Zamarano L, Cianci P, Muhlbauer M, Porter AT, Fontanesi J: Hyperbaric oxygen therapy for radiation-induced brain injury in children. Cancer 1997;80:2005-2012. (Pubitemid 27479797)
19. Kohshi K, Imada H, Nomoto S, Yamaguchi R, Abe H, Yamamoto H: Successful treatment of radiation-induced brain necrosis by hyperbaric oxygen therapy. J Neurol Sci 2003;209:115-117. (Pubitemid 36398687)
20. Clavo B, Robaina F, Montz R, Carames MA, Lloret M, Ponce P, Hernandez MA, Carreras JL: Modification of glucose metabolism in radiationinduced brain injury areas using cervical spinal cord stimulation. Acta Neurochir (Wien) 2009;151: 1419-1425.
21. Chan AS, Cheung MC, Law SC, Chan JH: Phase II study of alpha-tocopherol in improving the cognitive function of patients with temporal lobe radionecrosis. Cancer 2004;100:398-404. (Pubitemid 38063651)
22. Love S: Oxidative stress in brain ischemia. Brain Pathol 1999;9:119-131. (Pubitemid 29056523)
23. Sivakumar V, Ling EA, Lu J, Kaur C: Role of glutamate and its receptors and insulin-like growth factors in hypoxia induced periventricular white matter injury. Glia 2010;58:507-523.
24. Bocci V, Travagli V, Zanardi I: May oxygen-ozone therapy improves cardiovascular disorders? Cardiovasc Hematol Disord Drug Targets 2009;9:78-85.
25. Shiratori R, Kaneko Y, Kobayashi Y, Yamamoto Y, Sano H, Ishizu Y, Yamamoto T: Can ozone administration activate the tissue metabolism? -A study on brain metabolism during hypoxic hypoxia. Masui 1993;42:2-6. (Pubitemid 23066202)
26. Rodriguez MM, Garcia JR, Menendez S, Devesa E, Valverde S: Ozonoterapia en la enfermedad cerebrovascular isquémica. Revista CENIC Ciencias Biologicas 1998;29:145-148.