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Volumn 34, Issue 6, 2011, Pages 555-560

Phase 2 study of capecitabine and irinotecan combination chemotherapy (modified XELIRI regimen) in patients with advanced gastric cancer

Author keywords

capecitabine; gastric cancer; irinotecan; phase 2 trial

Indexed keywords

CAPECITABINE; IRINOTECAN;

EID: 81855166688     PISSN: 02773732     EISSN: 1537453X     Source Type: Journal    
DOI: 10.1097/COC.0b013e3181f47ac1     Document Type: Article
Times cited : (16)

References (37)
  • 1
    • 14944385553 scopus 로고    scopus 로고
    • Global cancer statistics
    • 10.3322/canjclin. 55.2.74.
    • Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics. CA Cancer J Clin 2005;55:74-108. Doi: 10.3322/canjclin. 55.2.74.
    • (2005) CA Cancer J. Clin. , vol.55 , pp. 74-108
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3
  • 2
    • 12844261474 scopus 로고    scopus 로고
    • Statistics on cancer in China: Cancer registration in 2002
    • 10.1158/1055-9965
    • Yang L, Parkin DM, Whelan S, et al. Statistics on cancer in China: cancer registration in 2002. Eur J Cancer Prev. 2005;14:329-335. Doi:10.1158/1055- 9965.
    • (2005) Eur. J. Cancer Prev. , Issue.14 , pp. 329-335
    • Yang, L.1    Parkin, D.M.2    Whelan, S.3
  • 3
    • 24944465318 scopus 로고    scopus 로고
    • Phase II multiinstitutional randomized trial of docetaxel plus cisplatin with or without fluorouracil in patients with untreated advanced gastric or gastroesophageal adenocarcinoma
    • 10.1200/JCO.2005.17.376
    • Ajani JA, Fodor MB, Tjulandin SA, et al. Phase II multiinstitutional randomized trial of docetaxel plus cisplatin with or without fluorouracil in patients with untreated, advanced gastric, or gastroesophageal adenocarcinoma. J Clin Oncol. 2005;23: 5660-5667. Doi: 10.1200/JCO.2005.17.376
    • (2005) J. Clin. Oncol. , vol.23 , pp. 5660-5667
    • Ajani, J.A.1    Fodor, M.B.2    Tjulandin, S.A.3
  • 4
    • 0032523070 scopus 로고    scopus 로고
    • Treatment of patients with advanced gastric carcinoma with a 5-fluorouracil-based or a cisplatin-based regimen: Two parallel randomized phase II studies
    • Barone C, Corsi DC, Pozzo C, et al. Treatment of patients with advanced gastric carcinoma with a 5-fluorouracil-based or a cisplatin-based regimen: two parallel randomized phase II studies. Cancer. 1998;82:1460-1467.
    • (1998) Cancer , vol.82 , pp. 1460-1467
    • Barone, C.1    Corsi, D.C.2    Pozzo, C.3
  • 5
    • 22144469838 scopus 로고    scopus 로고
    • Randomised phase II evaluation of irinotecan plus high-dose 5-fluorouracil and leucovorin ILF versus 5-fluorouracil leucovorin and etoposide ELF in untreated metastatic gastric cancer
    • 10.1038/sj.bjc.6602649.
    • Moehler M, Eimermacher A, Siebler J, et al. Randomised phase II evaluation of irinotecan plus high-dose 5-fluorouracil and leucovorin (ILF) versus 5-fluorouracil, leucovorin, and etoposide (ELF) in untreated metastatic gastric cancer. Br J Cancer. 2005;92:2122-2128. Doi: 10.1038/sj.bjc.6602649.
    • (2005) Br. J. Cancer , vol.92 , pp. 2122-2128
    • Moehler, M.1    Eimermacher, A.2    Siebler, J.3
  • 6
    • 33846953183 scopus 로고    scopus 로고
    • FOLFOX-4 regimen as first-line chemotherapy in elderly patients with advanced gastric cancer: A safety study
    • Nardi M, Azzarello D, Maisano R, et al. FOLFOX-4 regimen as first-line chemotherapy in elderly patients with advanced gastric cancer: a safety study. J Chemother. 2007;19:85-89.
    • (2007) J. Chemother , vol.19 , pp. 85-89
    • Nardi, M.1    Azzarello, D.2    Maisano, R.3
  • 7
    • 33646591539 scopus 로고    scopus 로고
    • Disparities in gastric cancer chemotherapy between the East and West
    • 10.1200/JCO.2006.05.9758.
    • Ohtsu A, Yoshida S, Saijo N, et al. Disparities in gastric cancer chemotherapy between the East and West. J Clin Oncol. 2006;24:2188-2196. Doi: 10.1200/JCO.2006.05.9758.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 2188-2196
    • Ohtsu, A.1    Yoshida, S.2    Saijo, N.3
  • 8
    • 33750949065 scopus 로고    scopus 로고
    • Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: A report of the V325 study group
    • 10.1200/JCO.2006.06.8429.
    • Van Cutsem E, Moiseyenko VM, Tjulandin S, et al. Phase III study of docetaxel and cisplatin plus fluorouracil compared with cisplatin and fluorouracil as first-line therapy for advanced gastric cancer: a report of the V325 Study Group. J Clin Oncol. 2006;24: 4991-4997. Doi: 10.1200/JCO.2006.06. 8429.
    • (2006) J. Clin. Oncol. , vol.24 , pp. 4991-4997
    • Van Cutsem, E.1    Moiseyenko, V.M.2    Tjulandin, S.3
  • 9
    • 48849094297 scopus 로고    scopus 로고
    • Randomized phase III study comparing irinotecan combined with 5-fluorouracil and folinic acid to cisplatin combined with 5-fluorouracil in chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction
    • 10.1093/annonc/mdn166.
    • Dank M, Zaluski J, Barone C, et al. Randomized phase III study comparing irinotecan combined with 5-fluorouracil and folinic acid to cisplatin combined with 5-fluorouracil in chemotherapy naive patients with advanced adenocarcinoma of the stomach or esophagogastric junction. Ann Oncol. 2008;19:1450-1457. Doi:10.1093/annonc/mdn166.
    • (2008) Ann. Oncol. , vol.19 , pp. 1450-1457
    • Dank, M.1    Zaluski, J.2    Barone, C.3
  • 10
    • 0036893770 scopus 로고    scopus 로고
    • Phase II study of oxaliplatin fluorouracil and folinic acid in locally advanced or metastatic gastric cancer patients
    • Louvet C, Andre T, Tigaud JM, et al. Phase II study of oxaliplatin, fluorouracil, and folinic acid in locally advanced or metastatic gastric cancer patients. J Clin Oncol. 2002;20:4543-4548.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 4543-4548
    • Louvet, C.1    Andre, T.2    Tigaud, J.M.3
  • 11
    • 1842852561 scopus 로고    scopus 로고
    • Weekly irinotecan in patients with metastatic gastric cancer failing cisplatin-based chemotherapy
    • Chun JH, Kim HK, Lee JS, et al. Weekly irinotecan in patients with metastatic gastric cancer failing cisplatin-based chemotherapy. Jpn J Clin Oncol. 2004;34:8-13.
    • (2004) Jpn. J. Clin. Oncol. , vol.34 , pp. 8-13
    • Chun, J.H.1    Kim, H.K.2    Lee, J.S.3
  • 12
    • 0028276113 scopus 로고
    • Late phase II study of irinotecan hydrochloride CPT-11 in advanced gastric cancer
    • CPT-C11 Gastrointestinal Cancer Study Group
    • Futatsuki K, Wakui A, Nakao I, et al. Late phase II study of irinotecan hydrochloride (CPT-11) in advanced gastric cancer. CPT-C11 Gastrointestinal Cancer Study Group. Gan To Kagaku Ryoho. 1994;21:1033-1038.
    • (1994) Gan. To. Kagaku. Ryoho. , vol.21 , pp. 1033-1038
    • Futatsuki, K.1    Wakui, A.2    Nakao, I.3
  • 13
    • 33745547767 scopus 로고    scopus 로고
    • Chemotherapy in advanced gastric cancer: A systematic review and metaanalysis based on aggregate data
    • 10.1200/JCO.2005.05.0245
    • Wagner AD, Grothe W, Haerting J, et al. Chemotherapy in advanced gastric cancer: a systematic review and metaanalysis based on aggregate data. J Clin Oncol. 2006;24:2903-2909. Doi: 10.1200/JCO.2005.05.0245
    • (2006) J. Clin. Oncol. , vol.24 , pp. 2903-2909
    • Wagner, A.D.1    Grothe, W.2    Haerting, J.3
  • 14
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study
    • Hoff PM, Ansari R, Batist G, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study. J Clin Oncol. 2001;19:2282-2292.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 2282-2292
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3
  • 15
    • 0031859855 scopus 로고    scopus 로고
    • Preliminary studies of a novel oral fluoropyrimidine carbamate: Capecitabine
    • Budman DR, Meropol NJ, Reigner B, et al. Preliminary studies of a novel oral fluoropyrimidine carbamate: capecitabine. J Clin Oncol. 1998;16:1795-1802.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 1795-1802
    • Budman, D.R.1    Meropol, N.J.2    Reigner, B.3
  • 16
    • 0031671094 scopus 로고    scopus 로고
    • Phase I and pharmacological study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer
    • Mackean MJ, Planting AS, Twelves C, et al. Phase I and pharmacological study of intermittent twice-daily oral therapy with capecitabine in patients with advanced and/or metastatic cancer. J Clin Oncol. 1998;16:2977-2985.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 2977-2985
    • Mackean, M.J.1    Planting, A.S.2    Twelves, C.3
  • 17
    • 63749118193 scopus 로고    scopus 로고
    • Capecitabine/cisplatin versus 5-fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: A randomised phase III noninferiority trial
    • 10.1093/annonc/mdn717.
    • Kang YK, Kang WK, Shin DB, et al. Capecitabine/cisplatin versus 5- fluorouracil/cisplatin as first-line therapy in patients with advanced gastric cancer: a randomised phase III noninferiority trial. Ann Oncol. 2009;20:666-673. Doi:10.1093/annonc/mdn717.
    • (2009) Ann. Oncol. , vol.20 , pp. 666-673
    • Kang, Y.K.1    Kang, W.K.2    Shin, D.B.3
  • 18
    • 38049047178 scopus 로고    scopus 로고
    • Capecitabine and oxaliplatin for advanced esophagogastric cancer
    • Cunningham D, Starling N, Rao S, et al. Capecitabine and oxaliplatin for advanced esophagogastric cancer. N Engl J Med. 2008;358:36-46.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 36-46
    • Cunningham, D.1    Starling, N.2    Rao, S.3
  • 19
    • 10744223904 scopus 로고    scopus 로고
    • Therapeutic synergy between irinotecan and 5-fluorouracil against human tumor xenografts
    • 10.1158/1078-0432.CCR-0913-3
    • Azrak RG, Cao S, Slocum HK, et al. Therapeutic synergy between irinotecan and 5-fluorouracil against human tumor xenografts. Clin Cancer Res. 2004;10:1121-1129. Doi: 10.1158/1078-0432.CCR- 0913-3.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 1121-1129
    • Azrak, R.G.1    Cao, S.2    Slocum, H.K.3
  • 20
    • 0031684654 scopus 로고    scopus 로고
    • Effect of adding the topoisomerase I poison 7-ethyl-10- hydroxycamptothecin SN-38 to 5-fluorouracil and folinic acid in HCT-8 cells: Elevated dTTP pools and enhanced cytotoxicity
    • 10.1007/s002800050835.
    • Mullany S, Svingen PA, Kaufmann SH, et al. Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN- 38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity. Cancer Chemother Pharmacol. 1998;42:391-399. Doi: 10.1007/s002800050835.
    • (1998) Cancer Chemother Pharmacol. , vol.42 , pp. 391-399
    • Mullany, S.1    Svingen, P.A.2    Kaufmann, S.H.3
  • 21
    • 21344457969 scopus 로고    scopus 로고
    • A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer
    • Rea DW, Nortier JW, Ten Bokkel Huinink WW, et al. A phase I/II and pharmacokinetic study of irinotecan in combination with capecitabine as first-line therapy for advanced colorectal cancer. Ann Oncol. 2005;16:1123-1132.
    • (2005) Ann. Oncol. , vol.16 , pp. 1123-1132
    • Rea, D.W.1    Nortier, J.W.2    Ten Bokkel Huinink, W.W.3
  • 22
    • 14644399903 scopus 로고    scopus 로고
    • Synergistic antitumor activity of capecitabine in combination with irinotecan
    • Cao S, Durrani FA, Rustum YM. Synergistic antitumor activity of capecitabine in combination with irinotecan. Clin Colorectal Cancer. 2005;4:336-343.
    • (2005) Clin. Colorectal Cancer , vol.4 , pp. 336-343
    • Cao, S.1    Durrani, F.A.2    Rustum, Y.M.3
  • 23
    • 20044384354 scopus 로고    scopus 로고
    • A randomized phase II trial of capecitabine and two different schedules of irinotecan in first-line treatment of metastatic colorectal cancer: Efficacy quality-of-life and toxicity
    • 10.1093/annonc/mdi047.
    • Borner MM, Bernhard J, Dietrich D, et al. A randomized phase II trial of capecitabine and two different schedules of irinotecan in first-line treatment of metastatic colorectal cancer: efficacy, quality-of-life and toxicity. Ann Oncol. 2005;16:282-288. Doi:10.1093/annonc/mdi047.
    • (2005) Ann. Oncol. , vol.16 , pp. 282-288
    • Borner, M.M.1    Bernhard, J.2    Dietrich, D.3
  • 24
    • 33646834287 scopus 로고    scopus 로고
    • Phase II study of capecitabine and irinotecan combination chemotherapy in patients with advanced gastric cancer
    • 10.1038/sj.bjc.6603093.
    • Baek JH, Kim JG, Jeon SB, et al. Phase II study of capecitabine and irinotecan combination chemotherapy in patients with advanced gastric cancer. Br J Cancer. 2006;94:1407-1411. Doi: 10.1038/sj.bjc.6603093.
    • (2006) Br. J. Cancer , vol.94 , pp. 1407-1411
    • Baek, J.H.1    Kim, J.G.2    Jeon, S.B.3
  • 25
    • 45749130769 scopus 로고    scopus 로고
    • Irinotecan plus S-1 IRIS versus S-1 alone as first line treatment for advanced gastric cancer: Preliminary results of a randomized phase III study GC0301/TOP-002
    • 2007 ASCO Annual Meeting Proceedings Post-Meeting Edition abstract 4525
    • Chin K, Iishi H, Imamura H, et al. Irinotecan plus S-1 (IRIS) versus S-1 alone as first line treatment for advanced gastric cancer: preliminary results of a randomized phase III study (GC0301/TOP- 002). 2007 ASCO Annual Meeting Proceedings (Post-Meeting Edition). J Clin Oncol. 2007;25(suppl 18S). (abstract 4525).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 S
    • Chin, K.1    Iishi, H.2    Imamura, H.3
  • 26
    • 35748972266 scopus 로고    scopus 로고
    • Randomized phase III study of 5-fluorouracil 5-FU alone versus combination of irinotecan and cisplatin CP versus S-1 alone in advanced gastric cancer JCOG9912
    • 2007 ASCO Annual Meeting Proceedings Post- Meeting Edition abstract 4513).
    • Boku N, Yamamoto S, Shirao K, et al. Randomized phase III study of 5-fluorouracil (5-FU) alone versus combination of irinotecan and cisplatin (CP) versus S-1 alone in advanced gastric cancer (JCOG9912). 2007 ASCO Annual Meeting Proceedings (Post- Meeting Edition). J Clin Oncol 2007;25(suppl 18S). (abstract 4513).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 S
    • Boku, N.1    Yamamoto, S.2    Shirao, K.3
  • 27
    • 40749153540 scopus 로고    scopus 로고
    • S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer spirits trial: A phase III trial
    • 10.1016/S1470-2045(08).
    • Koizumi W, Narahara H, Hara T, et al. S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial. Lancet Oncol. 2008;9:215-221. Doi:10.1016/S1470-2045(08).
    • (2008) Lancet Oncol. , vol.9 , pp. 215-221
    • Koizumi, W.1    Narahara, H.2    Hara, T.3
  • 28
    • 0742271770 scopus 로고    scopus 로고
    • Phase II study of irinotecan and 5-fluorouracil/leucovor in patients with primary refractory or relapsed advanced oesophageal and gastric carcinoma
    • Assersohn L, Brown G, Cunningham D, et al. Phase II study of irinotecan and 5-fluorouracil/leucovor in patients with primary refractory or relapsed advanced oesophageal and gastric carcinoma. Ann Oncol. 2004;15:64-69.
    • (2004) Ann. Oncol. , vol.15 , pp. 64-69
    • Assersohn, L.1    Brown, G.2    Cunningham, D.3
  • 29
    • 19944424421 scopus 로고    scopus 로고
    • Irinotecan in combination with 5-fluorouracil and folinic acid or with cisplatin in patients with advanced gastric or esophageal-gastric junction adenocarcinoma: Results of a randomized phase II study
    • 10.1093/annonc/mdh473.
    • Pozzo C, Barone C, Szanto J, et al. Irinotecan in combination with 5-fluorouracil and folinic acid or with cisplatin in patients with advanced gastric or esophageal-gastric junction adenocarcinoma: results of a randomized phase II study. Ann Oncol. 2004;15: 1773-1781. Doi:10.1093/annonc/mdh473.
    • (2004) Ann. Oncol. , vol.15 , pp. 1773-1781
    • Pozzo, C.1    Barone, C.2    Szanto, J.3
  • 30
    • 0036235128 scopus 로고    scopus 로고
    • First-line oral capecitabine therapy in metastatic colorectal cancer: A favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
    • Capecitabine Colorectal Cancer Study Group
    • Cassidy J, Twelves C, Van Cutsem E, et al; Capecitabine Colorectal Cancer Study Group. First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann Oncol. 2002;13:566-575.
    • (2002) Ann Oncol. , vol.13 , pp. 566-575
    • Cassidy, J.1    Twelves, C.2    Van Cutsem, E.3
  • 31
    • 0027198871 scopus 로고
    • A phase III randomized study of 5-fluorouracil and cisplatin versus 5-fluorouracil doxorubicin andmitomycin C versus 5-fluorouracil alone n the treatment of advanced gastric cancer
    • Kim NK, Park YS, Heo DS, et al. A phase III randomized study of 5-fluorouracil and cisplatin versus 5-fluorouracil, doxorubicin, andmitomycin C versus 5-fluorouracil alone n the treatment of advanced gastric cancer. Cancer. 1993;71:3813-3818.
    • (1993) Cancer , vol.71 , pp. 3813-3818
    • Kim, N.K.1    Park, Y.S.2    Heo, D.S.3
  • 32
    • 0032535648 scopus 로고    scopus 로고
    • A randomized phase III trial of etoposide epirubicin and cisplatin versus 5-fluorouracil epirubicin and cisplatin in the treatment of patients with advanced gastric carcinoma
    • Icli F, Celik I, Aykan F, et al. A randomized phase III trial of etoposide, epirubicin, and cisplatin versus 5-fluorouracil, epirubicin, and cisplatin in the treatment of patients with advanced gastric carcinoma. Cancer. 1998;83:2475-2480.
    • (1998) Cancer , vol.83 , pp. 2475-2480
    • Icli, F.1    Celik, I.2    Aykan, F.3
  • 33
    • 0034154069 scopus 로고    scopus 로고
    • Docetaxel taxotere-cisplatin TC: An effective drug combination in gastric carcinoma
    • Swiss Group for Clinical Cancer Research SAKK and the European Institute of Oncology EIO
    • Roth AD, Maibach R, Martinelli G, et al. Docetaxel (Taxotere)- cisplatin (TC): an effective drug combination in gastric carcinoma. Swiss Group for Clinical Cancer Research (SAKK), and the European Institute of Oncology (EIO). Ann Oncol. 2000;11:301-306.
    • (2000) Ann Oncol. , vol.11 , pp. 301-306
    • Roth, A.D.1    Maibach, R.2    Martinelli, G.3
  • 34
    • 0032919992 scopus 로고    scopus 로고
    • Phase II study of a combination of irinotecan and cisplatin against metastatic gastric cancer
    • Boku N, Ohtsu A, Shimada Y, et al. Phase II study of a combination of irinotecan and cisplatin against metastatic gastric cancer. J Clin Oncol. 1999;17:319-323.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 319-323
    • Boku, N.1    Ohtsu, A.2    Shimada, Y.3
  • 35
    • 34548295618 scopus 로고    scopus 로고
    • Distribution of the UGT1A1 *28 polymorphism in Caucasian and Asian populations in the US: A genomic analysis of 138 healthy individuals
    • 10.1097/CAD. 0b013e32803a46fe.
    • Liu JY, Qu K, Sferruzza AD, et al. Distribution of the UGT1A1. *28 polymorphism in Caucasian and Asian populations in the US: a genomic analysis of 138 healthy individuals. Anti-Cancer Drugs. 2007;18:693-696. Doi: 10.1097/CAD. 0b013e32803a46fe.
    • (2007) Anti-Cancer Drugs , vol.18 , pp. 693-696
    • Liu, J.Y.1    Qu, K.2    Sferruzza, A.D.3
  • 36
    • 4444351107 scopus 로고    scopus 로고
    • First-line chemotherapy with irinotecan plus capecitabine for advanced colorectal cancer
    • 10.1159/000079482.
    • Park SH, Bang SM, Cho EK, et al. First-line chemotherapy with irinotecan plus capecitabine for advanced colorectal cancer. Oncology. 2004;66:353-357. DOI: 10.1159/000079482.
    • (2004) Oncology , vol.66 , pp. 353-357
    • Park, S.H.1    Bang, S.M.2    Cho, E.K.3
  • 37
    • 21344466292 scopus 로고    scopus 로고
    • Multicenter phase II study of oral capecitabine plus irinotecan as first-line chemotherapy in advanced colorectal cancer: A Korean cancer study group rial
    • DOI 10.1080/028418605-10029590
    • Kim TW, Kang WK, Chang HM, et al. Multicenter phase II study of oral capecitabine plus irinotecan as first-line chemotherapy in advanced colorectal cancer: a Korean Cancer Study Group rial. Acta Oncol. 2005;44:230-235. DOI 10.1080/028418605- 10029590.
    • (2005) Acta Oncol. , vol.44 , pp. 230-235
    • Kim, T.W.1    Kang, W.K.2    Chang, H.M.3


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