Neuroradiological viewpoint on the diagnostics of space-occupying brain lesions

Clinical Neuroradiology

Volumn 21, Issue 3, 2011, Pages 123-139

  Faehndrich, J ^a   Weidauer, S ^b   Pilatus, U ^a   Oszvald, A ^a   Zanella, F E ^a   Hattingen, E ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Sankt Katharinen Krankenhaus GmbH   (Germany)

Author keywords

Brain tumors; Diffusion weighted imaging; Magnetic resonance spectroscopy; Perfusion weighted imaging; Presurgical

Indexed keywords

ALANINE; CHOLINE; CREATINE; CREATINE PHOSPHATE; INOSITOL; LACTIC ACID; LIPID; N ACETYLASPARTIC ACID;

ALGORITHM; BRAIN ABSCESS; BRAIN BLOOD VOLUME; BRAIN CANCER; BRAIN DISEASE; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN LYMPHOMA; BRAIN METABOLISM; BRAIN METASTASIS; BRAIN TUMOR; CANCER GRADING; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; DEMYELINATING DISEASE; DIAGNOSTIC IMAGING; DIFFUSION COEFFICIENT; DIFFUSION TENSOR IMAGING; DIFFUSION WEIGHTED IMAGING; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GLIOMA; HUMAN; INTRAOPERATIVE PERIOD; MENINGIOMA; METABOLITE; NEURORADIOLOGY; NEUROSURGERY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATIENT MONITORING; PERFUSION WEIGHTED IMAGING; PREOPERATIVE EVALUATION; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOLOGIST; REVIEW; TREATMENT PLANNING; WORLD HEALTH ORGANIZATION;

ASTROCYTOMA; BLOOD VOLUME; BRAIN; BRAIN NEOPLASMS; CONTRAST MEDIA; DIAGNOSIS, DIFFERENTIAL; DIFFUSION MAGNETIC RESONANCE IMAGING; ENERGY METABOLISM; GANGLIOGLIOMA; GLIOBLASTOMA; GLIOMA; HUMANS; IMAGE ENHANCEMENT; IMAGE PROCESSING, COMPUTER-ASSISTED; LYMPHOMA; MAGNETIC RESONANCE ANGIOGRAPHY; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; NEOPLASM GRADING; REGIONAL BLOOD FLOW; SENSITIVITY AND SPECIFICITY;

EID: 81755172041     PISSN: 09397116     EISSN: 16156706     Source Type: Journal    
DOI: 10.1007/s00062-011-0073-6     Document Type: Review

References (88)

1. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, editors. WHO classification of tumours of the central nervous system. Lyon: IARC; 2007.
2. Crespo-Rodríguez AM, Smirniotopoulos JG, Rushing EJ. MR and CT imaging of 24 pleomorphic xanthoastrocytomas (PXA) and a review of the literature. Neuroradiology. 2007;49:307-15. (Pubitemid 46510885)
3. Zentner J, Wolf HK, Ostertun B, Hufnagel A, Campos MG, Solymosi L, Schramm J. Gangliogliomas: clinical, radiological, and histopathological findings in 51 patients. J Neurol Neurosurg Psychiatry. 1994;57:1497-1502.
4. Kumar AJ, Leeds NE, Kumar VA, Fuller GN, Lang FF, Milas Z, Weinberg JS, Ater JL, Sawaya R. Magnetic resonance imaging features of pilocytic astrocytoma of the brain mimicking highgrade gliomas. J Comput Assist Tomogr. 2010;34:601-11.
5. Scott JN, Brasher PM, Sevick RJ. How often are nonenhancing supratentorial gliomas malignant? A population study. Neurology. 2002;59:947-9.
6. Senft C, Hattingen E, Pilatus U, Franz K, Schänzer A, Lanfermann H, Seifert V, Gasser T. Diagnostic value of proton magnetic resonance spectroscopy in the non-invasive grading of solid gliomas: comparison of maximum and mean choline values. Neurosurgery. 2009;65:908-13.
7. Ginsberg LE, Fuller GN, Hashmi M. The significance of lack of MR contrast enhancement of supratentorial brain tumors in adults: histopathological evaluation of a series. Surg Neurol. 1998;49:436-40. (Pubitemid 28153024)
8. Chaichana KL, Kosztowski T, Niranjan A, Olivi A, Weingart JD, Laterra J, Brem H, Quiñones-Hinojosa A. Prognostic significance of contrast-enhancing anaplastic astrocytomas in adults. J Neurosurg. 2010;113:286-92.
9. Dean BL, Drayer BP, Bird CR. Gliomas: classification with MR imaging. Radiology. 1990;174:411-5. (Pubitemid 20038599)
10. Law M, Young RJ, Babb JS. Gliomas: predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility- weighted contrast enhanced perfusion MR imaging. Radiology. 2008;247:490-8.
11. Weber MA, Vogt-Schaden M, Bossert O, Giesel FL, Kauczor HU, Essig M. MR perfusion and spectroscopic imaging in WHO grade II astrocytomas. Radiologe. 2007;47:812-8. (Pubitemid 47459032)
12. Moller-Hartmann W, Herminghaus S, Krings T, Marquardt G, Lanfermann H, Pilatus U, Zanella FE. Clinical application of proton magnetic resonance spectroscopy in the diagnosis of intracranial mass lesions. Neuroradiology. 2002;44:371-81. (Pubitemid 36097186)
13. Law M, Yang S, Wang H. Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging. Am J Neuroradiol. 2003;24:1989-98. (Pubitemid 37444849)
14. Floeth FW, Pauleit D, Wittsack HJ, Langen KJ, Reifenberger G, Hamacher K, Messing-Jünger M, Zilles K, Weber F, Stummer W, Steiger HJ, Woebker G, Müller HW, Coenen H, Sabel M. Multimodal metabolic imaging of cerebral gliomas: positron emission tomography with [18F]fluoroethyl-L-tyrosine and magnetic resonance spectroscopy. J Neurosurg. 2005;102:318-327. (Pubitemid 43194083)
15. Weckesser M, Langen KJ, Rickert CH, Kloska S, Straeter R, Hamacher K, Kurlemann G, Wassmann H, Coenen HH, Schober O. O-(2-[18F] fluorethyl)-L-tyrosine PET in the clinical evaluation of primary brain tumours. Eur J Nucl Med Mol Imaging. 2005;32:422-9. (Pubitemid 40591174)
16. Rachinger W, Goetz C, Pöpperl G, Gildehaus FJ, Kreth FW, Holtmannspötter M, Herms J, Koch W, Tatsch K, Tonn JC. Positron emission tomography with O-(2-[18F]fluoroethyl)-L-tyrosine versus magnetic resonance imaging in the diagnosis of recurrent gliomas. Neurosurgery. 2005;57:505-11. (Pubitemid 41254459)
17. Moseley ME, Kucharczyk J, Asgari H S, Norman D. Anisotropy in diffusion-weighted MRI. Mag Reson Med. 1991;19:321-6.
18. Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M. MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology. 1986;161:401-7. (Pubitemid 17173295)
19. Schaefer PW, Grant PE, Gonzalez RG. Diffusion-weighted MR imaging of the brain. Radiology. 2000;217:331-45.
20. Rosen BR, Belliveau JW, Chien D. Perfusion imaging by nuclear magnetic resonance. Magn Reson Q. 1989;5:263-81.
21. Aronen HJ, Gazit IE, Louis DN. Cerebral blood volume maps of gliomas: comparison with tumor grade and histologic findings. Radiology. 1994;191:41-51.
22. Cha S, Knopp EA, Johnson G, Wetzel SG, Litt AW, Zagzag D. Intracranial mass lesions: dynamic contrast-enhanced susceptibility- weighted echo-planar perfusion MR imaging. Radiology. 2002;223:11-29. (Pubitemid 34258186)
23. Shin JH, Lee HK, Kwun BD. Using relative cerebral blood flow and volume to evaluate the histopathologic grade of cerebral gliomas: preliminary results. Am J Roentgenol. 2000;175:207-19.
24. Warmuth C, Gunther M, Zimmer C. Quantification of blood flow in brain tumors: comparison of arterial spin labeling and dynamic susceptibility-weighted contrast-enhanced MR imaging. Radiology. 2003;228:523-32. (Pubitemid 36910097)
25. Aronen HJ, Perkio J. Dynamic susceptibility contrast MRI of gliomas. Neuroimaging Clin N Am. 2002;12:501-23. (Pubitemid 36015488)
26. Boxerman JL, Schmainda KM, Weisskoff RM. Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not. Am J Neuroradiol. 2006; 27:859-67. (Pubitemid 44897737)
27. Knopp EA, Cha S, Johnson G. Glial neoplasms: dynamic contrast-enhanced T2*-weighted MR imaging. Radiology. 1999;211:791-8. (Pubitemid 29249482)
28. Schmainda KM, Rand SD, Joseph AM, Lund R, Ward BD, Pathak AP, Ulmer JL, Badruddoja MA, Krouwer HG. Characterization of a first-pass gradient-echo spin-echo method to predict brain tumor grade and angiogenesis. Am J Neuroradiol. 2004;25:1524-32. (Pubitemid 44383603)
29. Uematsu H, Maeda M. Double-echo perfusion-weighted MR imaging: basic concepts and application in brain tumors for the assessment of tumor blood volume and vascular permeability. Eur Radiol. 2006;16:180-6. (Pubitemid 43103583)
30. Paulson ES, Schmainda KM. Comparison of dynamic susceptibility- weighted contrast-enhanced MR methods: recommendations for measuring relative cerebral blood volume in brain tumors. Radiology. 2008;249:601-13.
31. Lanfermann H, Herminghaus S, Pilatus U, Raab P, Wagner S, Zanella FE. Grundlagen der 1H-MR-Spektroskopie intrakranieller Tumoren. Klin Neuroradiol. 2002;12:1-17.
32. Shimizu H, Kumabe T, Shirane R. Correlation between choline levels measured by proton MR spectroscopy and Ki-67 labeling index in gliomas. Am J Neuroradiol. 2000;21:659-65. (Pubitemid 30210427)
33. Papanagiotou P, Backens M, Grunwald IQ. MR-Spektroskopie bei Hirntumoren. Radiologe. 2007;47:520-9.
34. Hattingen E, Pilatus U, Franz K, Zanella FE, Lanfermann H. Evaluation of optimal echo time for 1H-spectroscopic imaging of brain tumors at 3 Tesla. J Magn Reson Imaging. 2006;26:427-31.
35. Hattingen E, Raab P, Franz K, Zanella FE, Lanfermann H, Pilatus U. Myo-inositol: a marker of reactive astrogliosis in glial tumors? NMR Biomed. 2008;21:233-41. (Pubitemid 351513671)
36. Hattingen E, Raab P, Franz K, Lanfermann H, Setzer M, Gerlach R, Zanella FE, Pilatus U. Prognostic value of choline and creatine in WHO grade II gliomas. Neuroradiology. 2008;50:759-67.
37. Tedeschi G, Lundbom N, Raman R, Bonavita S, Duyn JH, Alger JR, Di Chiro G. Increased choline signal coinciding with malignant degeneration of cerebral gliomas: a serial proton magnetic resonance spectroscopy imaging study. J Neurosurg. 1997;87:516-24. (Pubitemid 27430397)
38. Kuesel AC, Briere KM, Halliday WC, Sutherland GR, Donnelly SM, Smith IC. Mobile lipid accumulation in necrotic tissue of high grade astrocytomas. Anticancer Res. 1996;16:1485-9. (Pubitemid 26257818)
39. Michaelis T, Merboldt KD, Bruhn H, Hänicke W, Frahm J. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology. 1993;187:219-27. (Pubitemid 23097888)
40. Kreis R. Issues of spectral quality in clinical 1H-magnetic resonance spectroscopy and a gallery of artifacts. NMR Biomed. 2004;17:361-81. (Pubitemid 39335175)
41. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30:672-729.
42. Masdeu JC, Quinto C, Olivera C, Tenner M, Leslie D, Visintainer P. Open-ring imaging sign: highly specific for atypical brain demyelination. Neurology. 2000;54:1427-33. (Pubitemid 30210460)
43. Traboulsee AL, Li DK. The role of MRI in the diagnosis of multiple sclerosis. Adv Neurol. 2006;98:125-46.
44. Kirov II, Patil V, Babb JS. MR Spectroscopy indicates diffuse multiple sclerosis activity during remission. J Neurol Neurosurg Psychiatry. 2009;80:1330-6.
45. Cha S, Pierce S, Knopp EA, Johnson G, Yang C, Ton A, Litt AW, Zagzag D. Dynamic contrast-enhanced T2*-weighted MR-imaging of tumefactive demyelinating lesions. AJNR Am J Neuroradiol. 2001;22:1109-16. (Pubitemid 32587424)
46. Blasel S, Pfeilschifter W, Jansen V, Mueller K, Zanella F, Hattingen E. Metabolism and regional cerebral blood volume in autoimmune inflammatory demyelinating lesions mimicking malignant gliomas. J Neurol. 2011;258:113-22.
47. Bousser MG, Ferro JM. Cerebral venous thrombosis: an update. Lancet Neurol. 2007;6:162-70. (Pubitemid 46097542)
48. Graham GD, Blamire AM, Rothman DL, Brass LM, Fayad PB, Petroff OA, Prichard JW. Early temporal variation of cerebral metabolites after human stroke. A proton magnetic resonance spectroscopy study. Stroke. 1993;24:1891-6. (Pubitemid 23352721)
49. Hattingen E, Franz K, Pilatus U, Weidauer S, Lanfermann H. Postictal spectroscopy and imaging findings mimicking brain tumor recurrence. J Magn Reson Imaging. 2006;24:226-30.
50. Szabo K, Poepel A, Pohlmann-Eden B, Hirsch J, Back T, Sedlaczek O, Hennerici M, Gass A. Diffusion-weighted and perfusion MRI demonstrates parenchymal changes in complex partial status epilepticus. Brain. 2005;128:1369-76. (Pubitemid 40826190)
51. Dujin JH, Matson GB, Maudsley AA. Human brain infarction: proton MR spectroscopy. Radiology. 1992;183:711-8.
52. Zhang D, Hu LB, Henning TD, Ravarani EM, Zou LG, Feng XY, Wang WX, Wen L. MRI findings of primary CNS lymphoma in 26 immunocompetent patients. Korean J Radiol. 2010;11:269-77.
53. Küker W, Nägele T, Korfel A, Heckl S, Thiel E, Bamberg M, Weller M, Herrlinger U. Primary central nervous system lymphomas (PCNSL): MRI features at presentation in 100 patients. J Neurooncol. 2005;72:169-77. (Pubitemid 40796468)
54. Calli C, Kitis O, Yunten N, Yurtseven T, Islekel S, Akalin T. Perfusion and diffusion MR imaging in enhancing malignant cerebral tumors. Eur J Radiol. 2006;58:394-403. (Pubitemid 43729064)
55. Guo AC, Cummings TJ, Dash RC, Provenzale JM. Lymphomas and high-grade astrocytomas: comparison of water diffusibility and histologic characteristics. Radiology. 2002;224:177-83. (Pubitemid 34680392)
56. Sugahara T, Korogi Y, Kochi M, Ushio Y, Takahashi M. Perfusion- sensitive MR imaging of gliomas: comparison between gradient- echo and spin-echo echo-planar imaging techniques. AJNR Am J Neuroradiol. 2001;22:1306-15. (Pubitemid 32734803)
57. Harting I, Hartmann M, Jost G, Sommer C, Ahmadi R, Heiland S, Sartor K. Differentiating primary central nervous system lymphoma from glioma in humans using localised proton magnetic resonance spectroscopy. Neurosci Lett. 2003;342:163-6. (Pubitemid 36570343)
58. Server A, Kulle B, Maehlen J, Josefsen R, Schellhorn T, Kumar T, Langberg CW, Nakstad PH. Quantitative apparent diffusion coefficients in the characterization of brain tumors and associated peritumoral edema. Acta Radiol. 2009;50:682-9.
59. Arvinda HR, Kesavadas C, Sarma PS, Thomas B, Radhakrishnan VV, Gupta AK, Kapilamoorthy TR, Nair S. Glioma grading: sensitivity, specificity, positive and negative predictive values of diffusion and perfusion imaging. J Neurooncol. 2009;94:87-96.
60. Price SJ. The role of advanced MR imaging in understanding brain tumour pathology. Br J Neurosurg. 2007;21:562-75. (Pubitemid 350249196)
61. Giulioni M, Galassi E, Zucchelli M, Volpi L. Seizure outcome of lesionectomy in glioneuronal tumors associated with epilepsy in children. J Neurosurg. 2005;102(3 Suppl):288-93. (Pubitemid 44954965)
62. Ostertun B, Wolf HK, Campos MG, Matus C, Solymosi L, Elger CE, Schramm J, Schild HH. Dysembryoplastic neuroepithelial tumors: MR and CT evaluation. AJNR Am J Neuroradiol. 1996;17:419-30. (Pubitemid 26101943)
63. Castillo M, Davis PC, Takei Y, Hoffman JC Jr. Intracranial ganglioglioma: MR, CT, and clinical findings in 18 patients. AJNR Am J Neuroradiol. 1990;11:109-14. (Pubitemid 20316499)
64. Im SH, Chung CK, Cho BK, Wang KC, Yu IK, Song IC, Cheon GJ, Lee DS, Kim NR, Chi JG. Intracranial ganglioglioma: preoperative characteristics and oncologic outcome after surgery. J Neurooncol. 2002;59:173-83. (Pubitemid 35021567)
65. Balaji R, Ramachandran K. Imaging of desmoplastic infantile ganglioglioma: a spectroscopic viewpoint. Childs Nerv Syst. 2009;25:497-501.
66. Bulakbasi N, Kocaoglu M, Ors F, Tayfun C, Uçöz T. Combination of single-voxel proton MR spectroscopy and apparent diffusion coefficient calculation in the evaluation of common brain tumors. AJNR Am J Neuroradiol. 2003;24:225-33. (Pubitemid 36237173)
67. Bulakbasi N, Kocaoglu M, Örs F. Dysembryoplastic neuroepithelial tumors: proton MR spectroscopy, diffusion and perfusion characteristics. Neuroradiology. 2007;49:805-12. (Pubitemid 47497770)
68. Tsuruda JS, Chew WM, Moseley ME, Norman D. Diffusion weighted MR imaging of the brain: value of differentiating between extraaxial cysts and epidermoid tumors. AJNR Am J Neuroradiol. 1990;11:925-31. (Pubitemid 20287535)
69. Ebisu T, Tanaka C, Umeda M, Kitamura M, Naruse S, Higuchi T, Ueda S, Sato H. Discrimination of brain abscess from necrotic or cystic tumors by diffusion-weighted echo planar imaging. Magn Reson Imaging. 1996;14:1113-6. (Pubitemid 27088231)
70. Atlas SW, DuBois P, Singer MB, Lu D. Diffusion measurements in intracranial hematomas: implications for MR imaging of acute stroke. AJNR Am J Neuroradiol. 2000;21:1190-4. (Pubitemid 30655651)
71. Hartmann M, Jansen O, Heiland S, Sommer C, Münkel K, Sartor K. Restricted diffusion within ring enhancement is not pathognomonic for brain abscess. AJNR Am J Neuroradiol. 2001;22:1738-42. (Pubitemid 32999585)
72. Haimes AB, Zimmerman RD, Morgello S. MR imaging of brain abscesses. AJR Am J Roentgenol. 1989;152:1073-85. (Pubitemid 19125142)
73. Schwartz KM, Erickson BJ, Lucchinetti C. Pattern of T2 hypointensity associated with ring-enhancing brain lesions can help to differentiate pathology. Neuroradiology. 2006;48:143-9. (Pubitemid 43380226)
74. Messerschmidt A, Prayer D, Olischar M, Pollak A, Birnbacher R. Brain abscesses after Serratia marcescens infection on a neonatal intensive care unit: differences on serial imaging. Neuroradiology. 2004;46:148-52. (Pubitemid 38396960)
75. Lai PH, Ho JT, Chen WL. Brain abscess and necrotic brain tumor: discrimination with proton MR spectroscopy and diffusionweighted imaging. AJNR Am J Neuroradiol. 2002;23:1369-77. (Pubitemid 35033888)
76. Scherer H. The forms of growth in gliomas and their practical significance. Brain. 1940;63:1-35.
77. Stadlbauer A, Buchfelder M, Doelken MT, Hammen T, Ganslandt O. Magnetic resonance spectroscopic imaging for visualization of the infiltration zone of glioma. Cen Eur Neurosurg. 2010 [Epub ahead of print].
78. Lee EJ, terBrugge K, Mikulis D, Choi DS, Bae JM, Lee SK, Moon SY. Diagnostic value of peritumoral minimum apparent diffusion coefficient for differentiation of glioblastoma multiforme from solitary metastatic lesions. AJR Am J Roentgenol. 2011;196:71-6.
79. Law M, Cha S, Knopp EA, Johnson G, Arnett J, Litt AW. Highgrade gliomas and solitary metastases: differentiation by using perfusion and proton spectroscopic MR imaging. Radiology. 2002;222:715-21. (Pubitemid 34215219)
80. Stadlbauer A, Nimsky C, Buslei R, Pinker K, Gruber S, Hammen T, Buchfelder M, Ganslandt O. Proton magnetic resonance spectroscopic imaging in the border zone of gliomas: correlation of metabolic and histological changes at low tumor infiltration - initial results. Invest Radiol. 2007;42:218-23. (Pubitemid 46398859)
81. Lu S, Ahn D, Johnson G, Law M, Zagzag D, Grossman RI. Diffusion- tensor MR imaging of intracranial neoplasia and associated peritumoral edema: introduction of the tumor infiltration index. Radiology. 2004;232:221-8. (Pubitemid 38787841)
82. Burtscher IM, Skagerberg G, Geijer B, Englund E, Ståhlberg F, Holtås S. Preoperative proton MR spectroscopic imaging of brain tumors: correlation with histopathologic analysis of resection specimens. AJNR Am J Neuroradiol. 2001;22:604-12.
83. Blasel S, Jurcoane A, Franz K, Morawe G, Pellikan S, Hattingen E. Elevated peritumoural rCBV values as a mean to differentiate metastases from high-grade gliomas. Acta Neurochir. 2010;152:1893-9.
84. Hermann EJ, Hattingen E, Krauss JK, Marquardt G, Pilatus U, Franz K, Setzer M, Gasser T, Tews DS, Zanella FE, Seifert V, Lanfermann H. Stereotactic biopsy in gliomas guided by 3-tesla 1H-chemical-shift imaging of choline. Stereotact Funct Neurosurg. 2008;86:300-307.
85. Hattingen E, Good C, Weidauer S, Herminghaus S, Raab P, Marquardt G, Raabe A, Seifert V, Zanella FE. Brain surface reformatted images for fast and easy localization of perirolandic lesions. J Neurosurg. 2005;102:302-10. (Pubitemid 43194081)
86. Stippich C. Presurgical functional magnetic resonance imaging. Radiologe. 2010;50:110-22
87. Hirsch J, Ruge MI, Karl HS. An integrated functional magnetic resonance imaging procedure for preoperative mapping of cortical areas associated with tactile, motor, language, and visual functions. Neurosurgery. 2000;47:711-21.
88. Jellison BJ, Field AS, Medow J. Diffusion tensor imaging of cerebral white matter: a pictorial review of physics, fiber tract anatomy, and tumor imaging patterns. AJNR Am J Neuroradiol. 2004;25:356-69. (Pubitemid 38374912)