The expression of E-cadherin and cathepsin-D in normal oral mucosa, oral epithelial dysplasia and oral squamous cell carcinoma: A comparative analysis between immunohistochemistry and routine histopathology

Journal of Oral and Maxillofacial Pathology

Volumn 15, Issue 3, 2011, Pages 288-294

  Yogesh, T L ^a   Narayan, T V ^b   Shreedhar, Balasundari ^c   Shashidara, R ^d   Leekymohanty, ^b  

^a Sri Rajiv Gandhi Dental College and Hospital   (India)

^b Hospital and Research Centre   (India)

^c Career Post Graduate Institute of Dental Sciences and Hospital   (India)

^d Rajiv Gandhi University of Health Sciences   (India)

Author keywords

Cathepsin D; dysplastic epithelium; E cadherin; immunohistochemistry; normal oral mucosa; oral squamous cell carcinoma

Indexed keywords

EID: 81555229262     PISSN: 0973029X     EISSN: 1998393X     Source Type: Journal    
DOI: 10.4103/0973-029X.86689     Document Type: Article

References (25)

1. Lo Muzio L, Pannone G, Leonardi R, Staibano S, Mignogna MD, De Rosa G, et al. Survivin, a potential early predictor of tumor progression in the oral mucosa. J Dent Res 2003;82:923-8 (Pubitemid 41756876)
2. Yonemura Y, Nojima N, Kaji M, Fujimura T, Itoh H, Ninomiya I, et al. E-cadherin and urokinase-type plasminogen activator tissue status in gastric carcinoma. Cancer 1995;76:941-53.
3. Mareel M, Leroy A. Clinical, cellular, and molecular aspects of cancer invasion. Physiol Rev 2002;83:337-76.
4. Wijnhoven BPL, Dinjens WNM, Pignatelli M. E-cadherincatenin cell-cell adhesion complex and human cancer. Br J Surg 2000;87;992-1005. (Pubitemid 30496847)
5. Smith MEF and Pignatelli M. The molecular histology of neoplasia: the role of the cadherin/catenin complex. Histopathology 1997;31:107-11. (Pubitemid 27357344)
6. Vessey CJ, Wilding J, Folarin N, Hirano S, Takeichi M, Soutter P, et al. Altered expression and function of E-cadherin in cervical intraepithelial neoplasia and invasive squamous cell carcinoma. J Pathol 1995;176:151-9.
7. Reid WA, Valler MJ, Kay J. Immunolocalization of cathepsin D in normal and neoplastic human tissues. J Clin Pathol 1986;39:1323-30. (Pubitemid 17223336)
8. Gandour-Edwards R, Trock B, Donald PJ. Predictive value of cathepsin-D for cervical lymph node metastasis in head and neck squamous cell carcinoma. Head Neck 1999;21:718-22.
9. Ikeguchi M, Sakatani T, Ueta T, Fukuda K, Oka S, Hisamitsu K, et al. Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma. J Clin Pathol 2002;55:121-6. (Pubitemid 34123913)
10. Smith CJ, Pindborg JJ. Histologic grading of oral epithelial dysplasia by the use of photographic standards. Copenhagen: WHO reference centre for oral precancerous conditions; 1969.
11. Bancoczy J, Csiba A. Occurrence of epithelial dysplasia in oral leukoplakia-Analysis and follow up study of 120 cases. Oral Surg Oral Med Oral Patho 1976;42:766-74.
12. Lumermann H, Freedman P, Kerpel S. Oral epithelial dysplasia and the development of invasive SCC. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995;79:321-9.
13. Speight P, Farthing PM, Bouquot JE. The pathology of oral cancer and precancer. Curr Diagn Pathol 1996;3:165-77.
14. Patel V, Leethanakul C, Gutkind JS. New approaches to the understanding of the molecular basis of oral cancer. Crit Rev Oral Biol Med 2001;12:55-63. (Pubitemid 32374284)
15. Thykjaer T, Workman C, Kruhøffer M, Demtröder K, Wolf H, Andersen LD, et al. Identification of gene expression patterns in superficial and invasive human bladder cancer. Cancer Res 2001;61:2492-9. (Pubitemid 32685829)
16. Sudbo J, Ried T, Bryne M, Kildal W, Danielsen H, Reith A. Abnormal DNA content predicts the occurrence of carcinomas in non-dysplastic oral white patches. Oral Oncol 2001;37: 558-65. (Pubitemid 32889617)
17. Sudbø J, Kildal W, Risberg B, Koppang HS, Danielsen HE, Reith A. DNA content as a prognostic marker in patients with oral leukoplakia. N Engl J Med 2001:344:1270-8. (Pubitemid 32372961)
18. Sudbø J, Kildal W, Johannessen AC, Koppang HS, Sudbø A, Danielsen HE, et al. Gross genomic aberrations in precancers: clinical implications of a long-term follow-up study in oral erythroplakias. J Clin Oncol 2002:20:456-62. (Pubitemid 34072529)
19. Williams HK, Sanders DS, Jankowski JA, Landini G, Brown AM. Expression of cadherins and catenins in oral epithelial dysplasia and squamous cell carcinoma. J Oral Pathol Med 1998;27:308-17. (Pubitemid 28382637)
20. Rochefort H, Liaudet-Coopman E. Cathepsin-D in cancer metastasis: a protease and a ligand. APIMS 1999;107:86-95. (Pubitemid 29133527)
21. Marsigliante S, Biscozzo L, Resta L, Leo G, Mottaghi A, Maiorano E, et al. Immunohistochemical and immunoradiometric evaluation of total cathepsin-D in human larynx. Eur J Cancer Oral Oncol 1994;30:51-5. (Pubitemid 24055775)
22. Horikoshi T, Arany I, Rajaraman S, Chen SH, Brysk H, Lei G, et al. Isoforms of cathepsin D and human epidermal differentiation. Biochime 1998;80:605-12. (Pubitemid 29151440)
23. Castiglioni T, Merino MJ, Elsner B, Lah TT, Sloane BF, Emmert-Buck MR. Immunohistochemical analysis of cathepsin D, B and L in human breast cancer. Hum Path 1994;25:857-62. (Pubitemid 24292400)
24. Behrens J, Mareel MM, Van Roy FM, Birchmeier W. Dissecting tumor cell invasion: Epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 1989;108:2435-47. (Pubitemid 19168932)
25. Andersen H, Mejlvang J, Mahmood S, Gromova I, Gromov P, Lukanidin E, et al. Immediate and delayed effects of E-cadherin inhibition on gene regulation and cell motility in human epidermoid carcinoma cells. Mol Cell Biol 2005;25:9138-50. (Pubitemid 41429101)