No evidence for statin-induced proteinuria in healthy volunteers as assessed by proteomic analysis

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Verhulst, Anja ^a   Geryl, Hilde ^a   D'Haese, Patrick ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; PRAVASTATIN; PROTEOME; RETINOL; ROSUVASTATIN; FLUOROBENZENE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PYRIMIDINE DERIVATIVE; RETINOL BINDING PROTEIN; SULFONAMIDE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN EXPERIMENT; KIDNEY TUBULE ABSORPTION; KIDNEY TUBULE EXCRETION; MALE; NORMAL HUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN URINE LEVEL; PROTEINURIA; PROTEOMICS; TWO DIMENSIONAL ELECTROPHORESIS; URINE; ALBUMINURIA; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS;

ADULT; AGED; ALBUMINURIA; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FLUOROBENZENES; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; PRAVASTATIN; PROTEINURIA; PROTEOME; PROTEOMICS; PYRIMIDINES; RETINOL-BINDING PROTEINS; SULFONAMIDES; TWO-DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS;

EID: 81555226049     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/456076     Document Type: Article

References (27)

1. Tobert J. A., Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors Nature Reviews Drug Discovery 2003 2 7 517 526 (Pubitemid 37361744)
2. Kovanen P. T., Bilheimer D. W., Goldstein J. L., Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog Proceedings of the National Academy of Sciences of the United States of America 1981 78 2 1194 1198 (Pubitemid 11102187)
3. Goldstein J. L., Brown M. S., Regulation of the mevalonate pathway Nature 1990 343 6257 425 430
4. Ma P., Gil G., Sudhof T. C., Bilheimer D., Goldstein J., Brown M., Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits Proceedings of the National Academy of Sciences of the United States of America 1986 83 21 8370 8374 (Pubitemid 17182502)
5. McFarlane S. I., Muniyappa R., Francisco R., Sowers J. R., Clinical review 145: pleiotropic effects of statins: lipid reduction and beyond Journal of Clinical Endocrinology and Metabolism 2002 87 4 1451 1458 (Pubitemid 34615220)
6. Wilmington D. E., Crestor [package insert]. AstraZeneca, 2003
7. Brewer H. B., Benefit-risk assessment of Rosuvastatin 10 to 40 milligrams The American Journal of Cardiology 2003 92 K23 K29
8. Vidt D. G., Cressman M. D., Harris S., Pears J. S., Hutchinson H. G., Rosuvastatin-induced arrest in progression of renal disease Cardiology 2004 102 1 52 60 (Pubitemid 38490263)
9. Verhulst A., D'Haese P. C., De Broe M. E., Inhibitors of HMG-CoA reductase reduce receptor-mediated endocytosis in human kidney proximal tubular cells Journal of the American Society of Nephrology 2004 15 9 2249 2257 (Pubitemid 39159325)
10. Sidaway J. E., Davidson R. G., McTaggart F., Orton T. C., Scott R. C., Smith G. J., Brunskill N. J., IInhibitors of HMG-CoA reductase reduce receptor-mediated endocytosis in opossum kidney cells Journal of the American Society of Nephrology 2004 15 9 2257 2265
11. Ellis S., Mellor H., Regulation of endocytic traffic by Rho family GTPases Trends in Cell Biology 2000 10 3 85 88 (Pubitemid 30110689)
12. Pizon V., Desjardins M., Bucci C., Parton R. G., Zerial M., Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex Journal of Cell Science 1994 107 6 1661 1670 (Pubitemid 24198484)
13. Rodman J. S., Wandinger-Ness A., Rab GTPases coordinate endocytosis Journal of Cell Science 2000 113 2 183 192 (Pubitemid 30088964)
14. Tiwari A., An overview of statin-associated proteinuria Drug Discovery Today 2006 11 9-10 458 464
15. Kassimatis T. I., Konstantinopoulos P. A., The role of statins in chronic kidney disease (CKD): friend or foe? Pharmacology and Therapeutics 2009 122 3 312 323
16. Shepherd K., Vidt D. G., Miller E., Harris S., Blasetto J., Safety of rosuvastatin: update on 16,876 rosuvastatin-treated patients in a multinational clinical trial program Cardiology 2007 107 4 433 443 (Pubitemid 46788271)
17. McKenney J. M., Davidson M. H., Jacobson T. A., Guyton J. R., Final conclusions and recommendations of the national lipid association statin safety assessment task force American Journal of Cardiology 2006 97 8 S89 S94
18. Kostapanos M. S., Milionis H. J., Saougos V. G., Lagos K. G., Kostara C., Bairaktari E. T., Elisaf M. S., Dose-dependent effect of rosuvastatin treatment on urinary protein excretion Journal of Cardiovascular Pharmacology and Therapeutics 2007 12 4 292 297 (Pubitemid 350264695)
19. Abbate M., Zoja C., Corna D., Capitanio M., Bertani T., Remuzzi G., In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation Journal of the American Society of Nephrology 1998 9 7 1213 1224 (Pubitemid 28283884)
20. Abbate M., Zoja C., Rottoli D., Corna D., Perico N., Bertani T., Remuzzi G., Antiproteinuric therapy while preventing the abnormal protein traffic in proximal tubule abrogates protein- and complement-dependent interstitial inflammation in experimental renal disease Journal of the American Society of Nephrology 1999 10 4 804 813 (Pubitemid 29149531)
21. Donadelli R., Zanchi C., Morigi M., Buelli S., Batani C., Tomasoni S., Corna D., Rottoli D., Benigni A., Abbate M., Remuzzi G., Zoja C., Protein overload induces fractalkine upregulation in proximal tubular cells through nuclear factor kB- and p38 mitogen-activated protein kinase-dependent pathways Journal of the American Society of Nephrology 2003 14 10 2436 2446 (Pubitemid 37169329)
22. Abbate M., Zoja C., Remuzzi G., How does proteinuria cause progressive renal damage? Journal of the American Society of Nephrology 2006 17 11 2974 2984 (Pubitemid 44707757)
23. Chana R., Sidaway J., Brunskill N., Statins but not thiazolidinediones attenuate album-mediated chemokine production ay proximal tubular cells independently of endocytosis American Journal of Nephrology 2010 28 823 830
24. Farmer J. A., Pleiotropic effects of statins Current Atherosclerosis Reports 2000 2 3 208 217
25. Massy Z. A., Guijarro C., Statins: effects beyond cholesterol lowering Nephrology Dialysis Transplantation 2001 16 9 1738 1741 (Pubitemid 32821398)
26. Katayama M., Kawata M., Yoshida Y., Horiuchi H., Yamamoto T., Matsuura Y., Takai Y., The posttranslationally modified C-terminal structure of bovine aortic smooth muscle rhoA p21 Journal of Biological Chemistry 1991 266 19 12639 12645 (Pubitemid 21907143)
27. Mitin N., Kudla A. J., Konieczny S. F., Taparowsky E. J., Differential effects of Ras signaling through NFkB on skeletal myogenesis Oncogene 2001 20 11 1276 1286 (Pubitemid 32269933)