Exploring potential sources of differential vulnerability and susceptibility in risk from environmental hazards to expand the scope of risk assessment

American Journal of Public Health

Volumn 101, Issue SUPPL. 1, 2011, Pages

  Schwartz, Joel ^a   Bellinger, David ^b   Glass, Thomas ^c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEAD;

AGE; AIR POLLUTANT; ARTICLE; DANGEROUS GOODS; ENVIRONMENTAL EXPOSURE; GENETIC PREDISPOSITION; HUMAN; MENTAL STRESS; RISK ASSESSMENT; SOCIOECONOMICS; VULNERABLE POPULATION;

AGE FACTORS; AIR POLLUTANTS; ENVIRONMENTAL EXPOSURE; GENETIC PREDISPOSITION TO DISEASE; HAZARDOUS SUBSTANCES; HUMANS; LEAD; RISK ASSESSMENT; SOCIOECONOMIC FACTORS; STRESS, PSYCHOLOGICAL; VULNERABLE POPULATIONS;

EID: 81555220941     PISSN: 00900036     EISSN: 15410048     Source Type: Journal    
DOI: 10.2105/AJPH.2011.300272     Document Type: Article

References (159)

1. Schwartz J, Bellinger D, Glass T. Expanding the scope of environmental risk assessment to better include differential vulnerability and susceptibility. Am J Public Health 2011;101(suppl 1):S88-S93.
2. Hackney JD, Linn WS, Buckley RD, et al. Experimental studies on human health effects of air pollutants: I. Design considerations. Arch Environ Health. 1975;30(8):373-378.
3. Kleeberger SR. Genetic aspects of susceptibility to air pollution. Eur Respir J. 2003;40:52s-56s. (Pubitemid 36565583)
4. Weuve J, Kelsey KT, Schwartz J, et al. Delta-aminolevulinic acid dehydratase polymorphism and the relation between low level lead exposure and the Mini-Mental Status Examination in older men: the Normative Aging Study. Occup Environ Med. 2006;63(11):746-753. (Pubitemid 44682640)
5. Rajan P, Kelsey KT, Schwartz JD, et al. Interaction of the delta-aminolevulinic acid dehydratase polymorphism and lead burden on cognitive function: the VA Normative Aging Study. J Occup Environ Med. 2008;50(9):1053-1061.
6. Krieg EF Jr, Butler MA, Chang MH, et al. Lead and cognitive function in ALAD genotypes in the third National Health and Nutrition Examination Survey. Neurotoxicol Teratol. 2009;31(6):364-371.
7. Stewart WF, Schwartz BS, Simon D, et al. ApoE genotype, past adult lead exposure, and neurobehavioral function. Environ Health Perspect. 2002;110(5):501-505. (Pubitemid 34546510)
8. Wright RO, Hu H, Silverman EK, et al. Apolipoprotein E genotype predicts 24-month bayley scales infant development score. Pediatr Res. 2003;54(6):819-825. (Pubitemid 37456545)
9. Lee BK, Glass TA, Wand GS, et al. Apolipoprotein E genotype, cortisol, and cognitive function in community-dwelling older adults. Am J Psychiatry. 2008;64(7):810-818.
10. Froehlich T, Lanphear B, Dietrich K, et al. Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Biol Psychiatry. 2007;62:243-249. (Pubitemid 47044877)
11. Weaver V, Lee B, Todd A, et al. Effect modification by delta-aminolevulinic acid dehydratase, vitamin D receptor, and nitric oxide synthase gene polymorphisms on associations between patella lead and renal function in lead workers. Environ Res. 2006;102:61-69. (Pubitemid 44080200)
12. Krieg EF Jr, Butler MA, Chang MH, et al. Lead and cognitive function in VDR genotypes in the third National Health and Nutrition Examination Survey. Neurotoxicol Teratol. 2010;32(2):262-272.
13. Wu J, Basha M, Zawia N. The environment, epigenetics and amyloidogenesis. J Mol Neurosci. 2008;34:1-7. (Pubitemid 351378089)
14. Pilsner JR, Hu H, Ettinger A, et al. Influence of prenatal lead exposure on genomic methylation of cord blood DNA. Environ Health Perspect. 2009;117(9):1466-1471.
15. Wright RO, Schwartz J, Wright RJ, et al. Biomarkers of lead exposure and DNA methylation within retrotransposons. Environ Health Perspect. 2010;118(6):790-795.
16. Chahine T, Baccarelli A, Litonjua A, et al. Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort. Environ Health Perspect. 2007;115(11):1617-1622.
17. Le Tertre A, Schwartz J, Touloumi G. Empirical Bayes and adjusted estimates approach to estimating the relation of mortality to exposure of PM (10). Risk Anal. 2005;25(3):711-718. (Pubitemid 41133012)
18. Ren C, Park SK, Vokonas P, et al. Air pollution and homocysteine: modification by oxidative stress related genes. Epidemiology. 2010;21(2):198-206.
19. Baja ES, Schwartz JD, Wellenius GA, et al. Traffic-related air pollution and QT interval: modification by diabetes, obesity, and oxidative stress gene polymorphisms in the Normative Aging Study. Environ Health Perspect. 2010;118:840-846.
20. Curjuric I, Imboden M, Schindler C, et al. HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction. Euro Respir J. 2010;35:505-514.
21. Alexeeff SE, Litonjua AA, Wright RO, et al. Ozone exposure, antioxidant genes, and lung function in an elderly cohort: VA Normative Aging Study. Occup Environ Med. 2008;65(11):736-742.
22. Islam T, Berhane K, McConnell R, et al. Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children. Thorax. 2009;64(3):197-202.
23. Schroer KT, Biagini Myers JM, Ryan PH, et al. Associations between multiple environmental exposures and glutathione S-transferase P1 on persistent wheezing in a birth cohort. J Pediatr. 2009;154(3):401-408.
24. Madrigano J, Baccarelli A, Wright R, et al. Air pollution, obesity, genes, and cellular adhesion molecules. Occup Environ Med. 2010:67:312-317.
25. Park SK, O'Neill MS, Wright RO, et al. HFE genotype, particulate air pollution, and heart rate variability: a geneenvironment interaction. Circulation. 2006;114(25):2798-2805. (Pubitemid 46018282)
26. Wilker E, Mittleman MA, Litonjua AA, et al. Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter. Environ Health Perspect. 2009;117(6):935-940.
27. Baccarelli A, Cassano PA, Litonjua A, et al. Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation. 2008;117(14):1802- 1809. (Pubitemid 351507468)
28. Wilker EH, Baccarelli A, Suh H, et al. Black carbon exposures, blood pressure and interactions with SNPs in microRNA processing genes. Environ Health Perspect. 2010;118(7):943-948.
29. Tarantini L, Bonzini M, Apostoli P, et al. Effects of particulate matter on genomic DNA methylation content and iNOS promoter methylation. Environ Health Perspect. 2009;117(2):217-222.
30. Perera F, Tang WY, Herbstman J, et al. Relation of DNA methylation of 59-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS ONE. 2009;4(2):e4488.
31. Baccarelli A, Wright RO, Bollati V, et al. Rapid DNA methylation changes after exposure to traffic particles. Am J Respir Crit Care Med. 2009;179:572-578.
32. Hamlin C. Predisposing causes and public health in early nineteenth century medical thought. Soc Hist Med. 1992;5:43-70.
33. Cassel J. The contribution of the social environment to host resistance: the Fourth Wade Hampton Frost Lecture. Am J Epidemiol. 1976;104(2):107-123.
34. McEwen BS, Stellar E. Stress and the individual. Mechanisms leading to disease. Arch Intern Med. 1993;153(18):2093-2101. (Pubitemid 23286462)
35. Park SK, O'Neill MS, Vokonas PS, et al. Air pollution and heart rate variability: effect modification by chronic lead exposure. Epidemiology. 2008;19(1):111-120. (Pubitemid 350295147)
36. Samet JM, Hatch GE, Horstman D, et al. Effect of antioxidant supplementation on ozone-induced lung injury in human subjects. Am J Respir Crit Care Med. 2001;164(5):819-825. (Pubitemid 32884241)
37. Tsaih SW, Korrick S, Schwartz J, et al. Lead, diabetes, hypertension, and renal function: the Normative Aging Study. Environ Health Perspect. 2004;112(11):1178-1182. (Pubitemid 39157619)
38. Park SK, Schwartz J, Weisskopf M, et al. Low-level lead exposure, metabolic syndrome, and heart rate variability: the VA Normative Aging Study. Environ Health Perspect. 2006;114(11):1718-1724. (Pubitemid 44718278)
39. Ekong EB, Jaar BG, Weaver VM. Lead-related nephrotoxicity: a review of the epidemiologic evidence. Kidney Int. 2006;70(12):2074-2084. (Pubitemid 44871369)
40. Zanobetti A, Schwartz J. Cardiovascular damage by airborne particles: are diabetics more susceptible? Epidemiology. 2002;13(5):588-592.
41. Goldberg MS, Burnett RT, Bailar JC 3rd, et al. The association between daily mortality and ambient air particle pollution in Montreal, Quebec. 2. Causespecific mortality. Environ Res. 2001;86(1):26-36.
42. Bateson TF, Schwartz J. Who is sensitive to the effects of particulate air pollution on mortality? A case-crossover analysis of effect modifiers. Epidemiology. 2004;15(2):143-149. (Pubitemid 40416967)
43. Forastiere F, Stafoggia M, Berti G, et al. Particulate matter and daily mortality: a case-crossover analysis of individual effect modifiers. Epidemiology. 2008;19(4):571-580.
44. O'Neill MS, Veves A, Zanobetti A, et al. Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function. Circulation. 2005;111(22):2913-2920. (Pubitemid 40814183)
45. Dubowsky SD, Suh H, Schwartz J, et al. Diabetes, obesity, and hypertension may enhance associations between air pollution and markers of systemic inflammation. Environ Health Perspect. 2006;114(7):992-998. (Pubitemid 44018893)
46. O'Neill MS, Veves A, Sarnat JA, et al. Air pollution and inflammation in type 2 diabetes: a mechanism for susceptibility. Occup Environ Med. 2007;64(6):373-379. (Pubitemid 46867138)
47. Chen JC, Cavallari JM, Stone PH, Christiani DC. Obesity is a modifier of autonomic cardiac responses to fine metal particulates. Environ Health Perspect. 2007;115(7):1002-1006. (Pubitemid 47317062)
48. Alexeeff SE, Litonjua AA, Suh H, et al. Ozone exposure and lung function: effect modified by obesity and airways hyperresponsiveness in the VA Normative Aging Study. Chest. 2007;132(6):1890-1897.
49. Johnston RA, Theman TA, Lu FL, et al. Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation. J Appl Physiol. 2008;104(6):1727-1735.
50. Lu FL, Johnston RA, Flynt L, et al. Increased pulmonary responses to acute ozone exposure in obese db/db mice. Am J Physiol Lung Cell Mol Physiol. 2006;290(5):L856-L865. (Pubitemid 43725047)
51. Schwartz J, Park SK, O'Neill MS, et al. Glutathione-S-transferase M1, obesity, statins, and autonomic effects of particles: gene-by-drug-by- environment interaction. Am J Respir Crit Care Med. 2005;172(12):1529-1533. (Pubitemid 43076541)
52. Zeka A, Sullivan JR, Vokonas PS, et al. Inflammatory markers and particulate air pollution: characterizing the pathway to disease. Int J Epidemiol. 2006;35(5):1347-1354. (Pubitemid 44605564)
53. Chen JC, Schwartz J. Metabolic syndrome and inflammatory responses to long-term particulate air pollutants. Environ Health Perspect. 2008;116(5):612-617. (Pubitemid 351864276)
54. Romieu I, Tellez-Rojo MM, Lazo M, et al. Omega-3 fatty acid prevents heart rate variability reductions associated with particulate matter. Am J Respir Crit Care Med. 2005;172(12):1534-1540. (Pubitemid 43076542)
55. Trenga CA, Koenig JQ, Williams PV. Dietary antioxidants and ozone-induced bronchial hyperresponsiveness in adults with asthma. Arch Environ Health. 2001;56(3):242-249.
56. Chrousos GP, Gold PW. The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA. 1992;267(9):1244-1252.
57. Augustin T, Glass TA, James BD, Schwartz BS. Neighborhood psychosocial hazards and cardiovascular disease: the Baltimore Memory Study. Am J Public Health. 2008;98(9):1664-1670.
58. Glass TA, Bandeen-Roche K, McAtee M, et al. Neighborhood psychosocial hazards and the association of cumulative lead dose with cognitive function in older adults. Am J Epidemiol. 2009;169(6):683-692.
59. Kubzansky LD. Sick at heart: the pathophysiology of negative emotions. Cleve Clin J Med. 2007;74(Suppl 1):S67-S72.
60. Hubbs-Tait L, Nation JR, Krebs NF, Bellinger DC. Neurotoxicants, micronutrients, and social environments: individual and combined effects of children's development. Psychol Sci Public Interest. 2005;6(3):57-121. (Pubitemid 43224084)
61. Calderon J, Navarro ME, Jimenez-Capdeville ME, et al. Exposure to arsenic and lead and neuropsychological development in Mexican children. Environ Res. 2001;85(2):69-76. (Pubitemid 32165774)
62. Selye H, Somogyi A, Vegh P. Inflammation, topical stress and the concept of pluricausal diseases. Biochem Pharmacol. 1968;17(Suppl):107-122.
63. Virgolini MB, Chen K, Weston DD, et al. Interactions of chronic lead exposure and intermittent stress: consequences for brain catecholamine systems and associated behaviors and HPA axis function. Toxicol Sci. 2005;87(2):469-482. (Pubitemid 41300694)
64. Cory-Slechta DA, Virgolini MB, Thiruchelvam M, et al. Maternal stress modulates the effects of developmental lead exposure. Environ Health Perspect. 2004;112(6):717-730. (Pubitemid 38628402)
65. Schneider JS, Lee MH, Anderson DW, et al. Enriched environment during development is protective against leadinduced neurotoxicity. Brain Res. 2001;896(1-2):48-55. (Pubitemid 32244146)
66. Bushnell PJ, Shelton SE, Bowman RE. Elevation of blood lead concentration by confinement in the rhesus monkey. Bull Environ Contam Toxicol. 1979;22(6):819-826. (Pubitemid 9246914)
67. Virgolini MB, Bauter MR, Weston DD, Cory-Slechta DA. Permanent alterations in stress responsivity in female offspring subjected to combined maternal lead exposure and/or stress. Neurotoxicology. 2006;27(1):11-21. (Pubitemid 41745004)
68. Lupien SJ, de Leon M, de Santi S, et al. Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat Neurosci. 1998;1(1):69-73. (Pubitemid 128652645)
69. Lupien SJ, Fiocco A, Wan N, et al. Stress hormones and human memory function across the lifespan. Psychoneuroendocrinology. 2005;30(3):225-242. (Pubitemid 39423357)
70. Lupien SJ, Lepage M. Stress, memory, and the hippocampus: can't live with it, can't live without it. Behav Brain Res. 2001;127(1-2):137-158. (Pubitemid 33062407)
71. Bowirrat A, Oscar-Berman M. Relationship between dopaminergic neurotransmission, alcoholism, and reward deficiency syndrome. Am J Med Genet B Neuropsychiatr Genet. 2005;132(1):29-37. (Pubitemid 40066191)
72. Peters JL, Kubzansky L, McNeely E, et al. Stress as a potential modifier of the impact of lead levels on blood pressure: the Normative Aging Study. Environ Health Perspect. 2007;115(8):1154-1159. (Pubitemid 351802346)
73. Peters J, Weisskopf M, Spiro A 3rd, et al. Interaction of stress, lead burden and age on cognition in older men: the Normative Aging Study. Environ Health Perspect. 2010;118(4):505-510.
74. Guilarte T, Toscano C, McGlothan J, Weaver S. Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure. Ann Neurol. 2003;53:50-56. (Pubitemid 36083828)
75. Schneider JS, Decamp E. Postnatal lead poisoning impairs behavioral recovery following brain damage. Neurotoxicology. 2007;28(6):1153-1157. (Pubitemid 350026592)
76. Wilson M, Johnston M, Goldstein G, Blue M. Neonatal lead exposure impairs development of rodent barrel field cortex. Proc Natl Acad Sci USA. 2000;97:5540-5545. (Pubitemid 30313754)
77. Wilson M, Blue M, Patra R. Neonatal lead exposure impairs plasticity in developing rat somatosensory cortex. Paper presented at: 23rd International Neurotoxicology Conference; September 17-21, 2006; Little Rock, AR.
78. Gump BB, Stewart P, Reihman J, et al. Prenatal and early childhood blood lead levels and cardiovascular functioning in 9 (1/2) year old children. Neurotoxicol Teratol. 2005;27(4):655-665. (Pubitemid 41112679)
79. Bellinger DC. Effect modification in epidemiologic studies of low-level neurotoxicant exposures and health outcomes. Neurotoxicol Teratol. 2000;22(1):133-140. (Pubitemid 30017985)
80. Clougherty JE, Levy JI, Kubzansky LD, et al. Synergistic effects of trafficrelated air pollution and exposure to violence on urban asthma etiology. Environ Health Perspect. 2007;115(8):1140-1146. (Pubitemid 351802344)
81. Chen E, Schreier HM, Strunk RC, Brauer M. Chronic traffic-related air pollution and stress interact to predict biologic and clinical outcomes in asthma. Environ Health Perspect. 2008;116(7):970-975. (Pubitemid 351943908)
82. Shankardass K, McConnell R, Jerrett M, et al. Parental stress increases the effect of traffic-related air pollution on childhood asthma incidence. Proc Natl Acad Sci USA. 2009;106(30):12406-12411.
83. Zeka A, Melly SJ, Schwartz J. The effects of socioeconomic status and indices of physical environment on reduced birth weight and preterm births in Eastern Massachusetts. Environ Health. 2008;7:60.
84. Marmot M. Health in an unequal world. Lancet. 2006;368(9552):2081-2094. (Pubitemid 44855089)
85. Hu H, Shih R, Rothenberg S, Schwartz BS. The epidemiology of lead toxicity in adults: measuring dose and consideration of other methodologic issues. Environ Health Perspect. 2007;115(3):455-462. (Pubitemid 46561900)
86. Miranda ML, Kim D, Reiter J, et al. Environmental contributors to the achievement gap. Neurotoxicology. 2009;30(6):1019-1024.
87. Rauh VA, Whyatt RM, Garfinkel R, et al. Developmental effects of exposure to environmental tobacco smoke and material hardship among inner-city children. Neurotoxicol Teratol. 2004;26(3):373-385. (Pubitemid 38534470)
88. Bellinger DC. Lead neurotoxicity and socioeconomic status: conceptual and analytical issues. Neurotoxicology. 2008;29(5):828-832.
89. Elreedy S, Krieger N, Ryan PB, et al. Relations between individual and neighborhood-based measures of socioeconomic position and bone lead concentrations among community-exposed men: the Normative Aging Study. Am J Epidemiol. 1999;150(2):129-141. (Pubitemid 29340147)
90. Krieger N, Chen JT, Waterman PD, et al. Choosing area based socioeconomic measures to monitor social inequalities in low birth weight and childhood lead poisoning: The Public Health Disparities Geocoding Project (US). J Epidemiol Community Health. 2003;57(3):186-199. (Pubitemid 36250180)
91. Forastiere F, Stafoggia M, Tasco C, et al. Socioeconomic status, particulate air pollution, and daily mortality: differential exposure or differential susceptibility. Am J Ind Med. 2007;50(3):208-216. (Pubitemid 46363812)
92. Ou CQ, Hedley AJ, Chung RY, et al. Socioeconomic disparities in air pollution-associated mortality. Environ Res. 2008;107(2):237-244.
93. Zanobetti A, Schwartz J. Race, gender, and social status as modifiers of the effects of PM10 on mortality. J Occup Environ Med. 2000;42(5):469-474. (Pubitemid 30316962)
94. Yi O, Kim H, Ha E. Does area level socioeconomic status modify the effects of PM (10) on preterm delivery? Environ Res. 2010;110(1):55-61.
95. Campbell A, Oldham M, Becaria A, et al. Particulate matter in polluted air may increase biomarkers of inflammation in mouse brain. Neurotoxicology. 2005;26(1):133-140. (Pubitemid 39440973)
96. Akiyama H, Barger S, Barnum S, et al. Inflammation and Alzheimer's disease. Neurobiol Aging. 2000;21(3):383-421. (Pubitemid 30349107)
97. Fischer P, Hoek G, Brunekreef B, et al. Air pollution and mortality in The Netherlands: are the elderly more at risk? Eur Respir J Suppl. 2003;40:34s-38s. (Pubitemid 36565580)
98. Aga E, Samoli E, Touloumi G, et al. Short-term effects of ambient particles on mortality in the elderly: results from 28 cities in the APHEA2 project. Eur Respir J Suppl. 2003;40:28s-33s. (Pubitemid 36565579)
99. Devlin RB, Ghio AJ, Kehrl H, et al. Elderly humans exposed to concentrated air pollution particles have decreased heart rate variability. Eur Respir J Suppl. 2003;40:76s-80s. (Pubitemid 36565587)
100. Moya J, Bearer C, Etzel R. Children's behavior and physiology and how it affects exposure to environmental contaminants. Pediatrics. 2004;113:996-1006. (Pubitemid 38437352)
101. Langston C, Kida K, Reed M, Thurlbeck WM. Human lung growth in late gestation and in the neonate. Am Rev Respir Dis. 1984;129:607-613. (Pubitemid 14126782)
102. Fanucchi MV, Plopper CG, Evans MJ, et al. Cyclic exposure to ozone alters distal airway development in infant rhesus monkeys. Am J Physiol Lung Cell Mol Physiol. 2006;291(4):L644-L650. (Pubitemid 44498475)
103. Chandra A, Ali M, Saxena D, Murthy R. Behavioral and neurochemical changes in rats simultaneously exposed to manganese and lead. Arch Toxicol. 1981;49:49-56. (Pubitemid 12253310)
104. Chandra A, Murthy R, Saxena D, Lal B. Effects of pre-and postnatal combined exposure to Pb and Mn on brain development in rats. Ind Health. 1983;21:273-279. (Pubitemid 14179277)
105. Rodriguez VM, Dufour L, Carrizales L, et al. Effects of oral exposure to mining waste on in vivo dopamine release from rat striatum. Environ Health Perspect. 1998;106(8):487-491. (Pubitemid 28470164)
106. Mejia JJ, Diaz-Barriga F, Calderon J, et al. Effects of lead-arsenic combined exposure on central monoaminergic systems. Neurotoxicol Teratol. 1997;19(6):489-497. (Pubitemid 27489352)
107. Claus Henn B, Ettinger A, Schwartz J, et al. Early postnatal blood manganese levels and children's neurodevelopment. Epidemiology. 2010;21(4):433-439.
108. Kim Y, Kim BN, Hong YC, et al. Coexposure to environmental lead and manganese affects the intelligence of school-aged children. Neurotoxicology. 2009;30(4):564-571.
109. Navas-Acien A, Tellez-Plaza M, Guallar E, et al. Blood cadmium and lead and chronic kidney disease in US adults: a joint analysis. Am J Epidemiol. 2009;170(9):1156-1164.
110. Mahaffey KR, Annest JL, Roberts J, Murphy RS. National estimates of blood lead levels: United States, 1976-1980: association with selected demographic and socioeconomic factors. N Engl J Med. 1982;307(10):573-579. (Pubitemid 12043958)
111. Mahaffey KR, Gartside PS, Glueck CJ. Blood lead levels and dietary calcium intake in 1-to 11-year-old children: the Second National Health and Nutrition Examination Survey, 1976 to 1980. Pediatrics. 1986;78(2):257-262. (Pubitemid 16039554)
112. Jones RL, Homa DM, Meyer PA, et al. Trends in blood lead levels and blood lead testing among US children aged 1 to 5 years, 1988-2004. Pediatrics. 2009;123(3):e376-e385.
113. Shaik AP, Jamil K. A study on the ALAD gene polymorphisms associated with lead exposure. Toxicol Ind Health. 2008;24(7):501-506.
114. Shen XM, Wu SH, Yan CH, et al. Delta-aminolevulinate dehydratase polymorphism and blood lead levels in Chinese children. Environ Res. 2001;85(3):185-190.
115. Sobin C, Gutierrez M, Alterio H. Polymorphisms of delta-aminolevulinic acid dehydratase (ALAD) and peptide transporter 2 (PEPT2) genes in children with low-level lead exposure. Neurotoxicology. 2009;30(6):881-887.
116. Montenegro MF, Barbosa F Jr, Sandrim VC, et al. A polymorphism in the delta-aminolevulinic acid dehydratase gene modifies plasma/whole blood lead ratio. Arch Toxicol. 2006;80(7):394-398. (Pubitemid 43873729)
117. Hopkins MR, Ettinger AS, Hernandez-Avila M, et al. Variants in iron metabolism genes predict higher blood lead levels in young children. Environ Health Perspect. 2008;116(9):1261-1266.
118. Theppeang K, Schwartz BS, Lee BK, et al. Associations of patella lead with polymorphisms in the vitamin D receptor, delta-aminolevulinic acid dehydratase and endothelial nitric oxide synthase genes. J Occup Environ Med. 2004;46(6):528-537. (Pubitemid 38747698)
119. Pritchard JK. Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet. 2001;69(1):124-137. (Pubitemid 32614025)
120. Wu S, Yan C, Shen X. Molecular genetic susceptibility to lead poisoning. J Hygiene Res. 2004;33(2):226-228, 232.
121. Fujihara J, Agusa T, Yasuda T, et al. Ethnic variation in genotype frequencies of delta-aminolevulinic acid dehydratase (ALAD). Toxicol Lett. 2009;191(2-3):236-239.
122. Elmarsafawy SF, Jain NB, Schwartz J, et al. Dietary calcium as a potential modifier of the relationship of lead burden to blood pressure. Epidemiology. 2006;17(5):531-537. (Pubitemid 44223061)
123. Cheng Y, Willett WC, Schwartz J, et al. Relation of nutrition to bone lead and blood lead levels in middle-aged to elderly men. The Normative Aging Study. Am J Epidemiol. 1998;147(12):1162-1174. (Pubitemid 28285459)
124. Solon O, Riddell TJ, Quimbo SA, et al. Associations between cognitive function, blood lead concentration, and nutr0ition among children in the central Philippines. J Pediatr. 2008;152(2):237-243.
125. Mohai P, Lantz PM, Morenoff J, et al. Racial and socioeconomic disparities in residential proximity to polluting industrial facilities: evidence from the Americans' Changing Lives Study. Am J Public Health. 2009;99(Suppl 3):S649-S656.
126. Havard S, Deguen S, Zmirou-Navier D, et al. Traffic-related air pollution and socioeconomic status: a spatial autocorrelation study to assess environmental equity on a small-area scale. Epidemiology. 2009;20(2):223-230.
127. Yanosky JD, Schwartz J, Suh HH. Associations between measures of socioeconomic position and chronic nitrogen dioxide exposure in Worcester, Massachusetts. J Toxicol Environ Health A. 2008;71(24):1593-1602.
128. Mirabelli MC, Wing S, Marshall SW, Wilcosky TC. Race, poverty, and potential exposure of middle-school students to air emissions from confined swine feeding operations. Environ Health Perspect. 2006;114(4):591-596.
129. Woodruff TJ, Parker JD, Kyle AD, Schoendorf KC. Disparities in exposure to air pollution during pregnancy. Environ Health Perspect. 2003;111(7):942-946. (Pubitemid 36790390)
130. Baxter LK, Clougherty JE, Laden F, Levy JI. Predictors of concentrations of nitrogen dioxide, fine particulate matter, and particle constituents inside of lower socioeconomic status urban homes. J Expo Sci Environ Epidemiol. 2007;17(5):433-444. (Pubitemid 47237635)
131. Stevens GA, Dias RH, Ezzati M. The effects of 3 environmental risks on mortality disparities across Mexican communities. Proc Natl Acad Sci USA. 2008;105(44):16860-16865.
132. Cheng Y, Schwartz J, Sparrow D, et al. Bone lead and blood lead levels in relation to baseline blood pressure and the prospective development of hypertension: the Normative Aging Study. Am J Epidemiol. 2001;153(2):164-171. (Pubitemid 32060608)
133. Hu H, Aro A, Payton M, et al. The relationship of bone and blood lead to hypertension. The Normative Aging Study. JAMA. 1996;275(15):1171-1176. (Pubitemid 26113932)
134. Jain NB, Potula V, Schwartz J, et al. Lead levels and ischemic heart disease in a prospective study of middle-aged and elderly men: the VA Normative Aging Study. Environ Health Perspect. 2007;115(6):871-875. (Pubitemid 46902241)
135. Schwartz J. Lead, blood pressure, and cardiovascular disease in men. Arch Environ Health. 1995;50(1):31-37.
136. Weisskopf MG, Jain N, Nie H, et al. A prospective study of bone lead concentration and death from all causes, cardiovascular diseases, and cancer in the Department of Veterans Affairs Normative Aging Study. Circulation. 2009;120(12):1056-1064.
137. Geronimus AT. The weathering hypothesis and the health of African-American women and infants: evidence and speculations. Ethn Dis. 1992;2(3):207-221.
138. Geronimus AT, Hicken M, Keene D, Bound J. "Weathering" and age patterns of allostatic load scores among blacks and whites in the United States. Am J Public Health. 2006;96(5):826-833.
139. McEwen BS. Allostasis and allostatic load: implications for neuropsychopharmacology. Neuropsychopharmacology. 2000;22(2):108-124. (Pubitemid 30016013)
140. Zartarian VG, Schultz BD. The EPA's human exposure research program for assessing cumulative risk in communities. J Expo Sci Environ Epidemiol. 2010;20(4):351-358.
141. Menzie CA, MacDonell MM, Mumtaz M. A phased approach for assessing combined effects from multiple stressors. Environ Health Perspect. 2007;115(5):807-816. (Pubitemid 46785053)
142. Blackburn EH. Switching and signaling at the telomere. Cell. 2001;106(6):661-673. (Pubitemid 32900658)
143. Wong JM, Collins K. Telomere maintenance and disease. Lancet. 2003;362(9388):983-988. (Pubitemid 37159296)
144. Aviv A. Chronology versus biology: telomeres, essential hypertension, and vascular aging. Hypertension. 2002;40(3):229-232. (Pubitemid 35006702)
145. Fitzpatrick AL, Kronmal RA, Gardner JP, et al. Leukocyte telomere length and cardiovascular disease in the Cardiovascular Health Study. Am J Epidemiol. 2007;165(1):14-21. (Pubitemid 46026204)
146. Yang Z, Huang X, Jiang H, et al. Short telomeres and prognosis of hypertension in a Chinese population. Hypertension. 2009;53(4):639-645.
147. Perez-Rivero G, Ruiz-Torres MP, Rivas-Elena JV, et al. Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Circulation. 2006;114(4):309-317. (Pubitemid 44297097)
148. Vasan RS, Massaro JM, Wilson PW, et al. Antecedent blood pressure and risk of cardiovascular disease: the Framingham Heart Study. Circulation. 2002;105(1):48-53. (Pubitemid 34049141)
149. Benetos A, Gardner JP, Zureik M, et al. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension. 2004;43(2):182-185. (Pubitemid 38174171)
150. Brouilette SW, Moore JS, McMahon AD, et al. Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study. Lancet. 2007;369(9556):107-114. (Pubitemid 46073129)
151. Mukherjee M, Brouilette S, Stevens S, et al. Association of shorter telomeres with coronary artery disease in Indian subjects. Heart. 2009;95(8):669-673.
152. van der Harst P, van der Steege G, de Boer RA, et al. Telomere length of circulating leukocytes is decreased in patients with chronic heart failure. J Am Coll Cardiol. 2007;49(13):1459-1464.
153. Edo MD, Andres V. Aging, telomeres, and atherosclerosis. Cardiovasc Res. 2005;66(2):213-221. (Pubitemid 40471036)
154. Honda S, Hjelmeland LM, Handa JT. Oxidative stress-induced single-strand breaks in chromosomal telomeres of human retinal pigment epithelial cells in vitro. Invest Ophthalmol Vis Sci. 2001;42(9):2139-2144. (Pubitemid 32726050)
155. Saretzki G, Von Zglinicki T. Replicative aging, telomeres, and oxidative stress. Ann N Y Acad Sci. 2002;959:24-29. (Pubitemid 34457548)
156. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem Sci. 2002;27(7):339-344. (Pubitemid 34756516)
157. Nawrot TS, Staessen JA, Gardner JP, Aviv A. Telomere length and possible link to X chromosome. Lancet. 2004;363(9408):507-510. (Pubitemid 38229449)
158. Muller KC, Welker L, Paasch K, et al. Lung fibroblasts from patients with emphysema show markers of senescence in vitro. Respir Res. 2006;7:32.
159. Hoxha M, Dioni L, Bonzini M, et al. Association between leukocyte telomere shortening and exposure to traffic pollution: a cross-sectional study on traffic officers and indoor office workers. Environ Health. 2009;8:41.