Application of PAT tools for the safe and reliable production of a dihydro-1 H -imidazole

Organic Process Research and Development

Volumn 15, Issue 6, 2011, Pages 1458-1463

  Barrios Sosa, Ana C ^a   Conway, Ryan ^a   Williamson, R Thomas ^a   Suchy, James P ^a   Edwards, William ^a   Cleary, Thomas ^a  

^a Roche Carolina   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BATCH TRANSFER; CHIRAL RESOLUTIONS; COCRYSTALLIZATION; CRYSTALLIZATION PROCESS; LASENTEC; PROBE-BASED; PROCESS ANALYTICAL TECHNOLOGY; REAL-TIME DATA;

STEREOCHEMISTRY;

EID: 81555213074     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op2001172     Document Type: Article

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16. This byproduct was produced in 10 to 20 area % based on HPLC data. Characterization by LCMS was hindered by the instability of this compound. Attempts to react this byproduct with piperazine 6 to produce rac 8 under the reaction conditions were unsuccessful.
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20. The unit was equipped with a D600L Probe (diameter: 19 mm, length: 400 mm) constructed from Alloy C-276 with Kalrez seals.