Splenic elasticity measured with real-time tissue elastography is a marker of portal hypertension

Radiology

Volumn 261, Issue 3, 2011, Pages 960-968

  Hirooka, Masashi ^a   Ochi, Hironori ^a   Koizumi, Yohei ^a   Kisaka, Yoshiyasu ^a   Abe, Masanori ^a   Ikeda, Yoshio ^a   Matsuura, Bunzo ^a   Hiasa, Yoichi ^a   Onji, Morikazu ^a  

^a EHIME UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; CHRONIC LIVER DISEASE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE MARKER; DOPPLER ECHOGRAPHY; ELASTOGRAPHY; ESOPHAGOGASTRODUODENOSCOPY; ESOPHAGUS VARICES; FEMALE; HUMAN; INFORMED CONSENT; LIVER BLOOD FLOW; LIVER FIBROSIS; LYMPHATIC PARAMETERS; MAJOR CLINICAL STUDY; MALE; PILOT STUDY; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PREDICTION; PREDICTIVE VALUE; PRESSURE GRADIENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; REAL TIME TISSUE ELASTOGRAPHY; RECEIVER OPERATING CHARACTERISTIC; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; SPLEEN BLOOD FLOW; SPLENIC ELASTICITY;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; ELASTICITY IMAGING TECHNIQUES; FEMALE; HUMANS; HYPERTENSION, PORTAL; LIVER; LOGISTIC MODELS; MALE; MIDDLE AGED; PILOT PROJECTS; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; ROC CURVE; SENSITIVITY AND SPECIFICITY; SPLEEN; ULTRASONOGRAPHY, DOPPLER;

EID: 81555212304     PISSN: 00338419     EISSN: 15271315     Source Type: Journal    
DOI: 10.1148/radiol.11110156     Document Type: Article

References (34)

1. Mahl TC, Groszmann RJ. Pathophysiology of portal hypertension and variceal bleeding. Surg Clin North Am 1990;70(2):251-266. (Pubitemid 20105429)
2. D'Amico G, Garcia-Tsao G, Pagliaro L. Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies. J Hepatol 2006;44(1): 217-231. (Pubitemid 41772537)
3. Salerno F, Guevara M, Bernardi M, et al. Refractory ascites: pathogenesis, definition and therapy of a severe complication in patients with cirrhosis. Liver Int 2010;30(7): 937-947.
4. Lee JM, Han KH, Ahn SH. Ascites and spontaneous bacterial peritonitis: an Asian perspective. J Gastroenterol Hepatol 2009; 24(9):1494-1503.
5. Thalheimer U, Leandro G, Samonakis DN, Triantos CK, Patch D, Burroughs AK. Assessment of the agreement between wedge hepatic vein pressure and portal vein pressure in cirrhotic patients. Dig Liver Dis 2005;37(8):601-608. (Pubitemid 44356073)
6. Ripoll C, Bañares R, Rincón D, et al. Influence of hepatic venous pressure gradient on the prediction of survival of patients with cirrhosis in the MELD era. Hepatology 2005; 42(4):793-801. (Pubitemid 41401116)
7. D'Amico G, Garcia-Pagan JC, Luca A, Bosch J. Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: a systematic review. Gastroenterology 2006;131(5):1611-1624. (Pubitemid 44708947)
8. Talwalkar JA, Yin M, Venkatesh S, et al. Feasibility of in vivo MR elastographic splenic stiffness measurements in the assessment of portal hypertension. AJR Am J Roentgenol 2009;193(1):122-127.
9. Manenti A, Botticelli A, Gibertini G, Botticelli L. Experimental congestive splenomegaly: histological observations in the rat. Pathologica 1993;85(1100):721-724.
10. Cavalli G, Re G, Casali AM. Red pulp arterial terminals in congestive splenomegaly: a morphometric study. Pathol Res Pract 1984;178(6):590-594. (Pubitemid 14030284)
11. Re G, Casali AM, Cavalli D, Guida G, Cau R, Cavalli G. Histometric analysis of white pulp arterial vessels in congestive sple nomegaly. Appl Pathol 1986;4(1-2):98-103. (Pubitemid 17028699)
12. Terayama N, Makimoto KP, Kobayashi S, et al. Pathology of the spleen in primary biliary cirrhosis: an autopsy study. Pathol Int 1994;44(10-11):753-758. (Pubitemid 24320462)
13. Vizzutti F, Arena U, Rega L, et al. Performance of Doppler ultrasound in the prediction of severe portal hypertension in hepatitis C virus-related chronic liver disease. Liver Int 2007;27(10):1379-1388. (Pubitemid 350142252)
14. Vizzutti F, Arena U, Romanelli RG, et al. Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis . Hepatology 2007;45(5):1290-1297. (Pubitemid 46775793)
15. Carrión JA, Navasa M, Bosch J, Bruguera M, Gilabert R, Forns X. Transient elastography for diagnosis of advanced fibrosis and portal hypertension in patients with hepatitis C recurrence after liver transplantation. Liver Transpl 2006;12(12):1791-1798. (Pubitemid 44911805)
16. Koizumi Y, Hirooka M, Kisaka Y, et al. Liver fibrosis in patients with chronic hepatitis C: noninvasive diagnosis by means of real-time tissue elastography: establishment of the method for measurement. Radiology 2011; 258(2):610-617.
17. Hirata M, Akbar SM, Horiike N, Onji M. Noninvasive diagnosis of the degree of hepatic fibrosis using ultrasonography in patients with chronic liver disease due to hepatitis C virus. Eur J Clin Invest 2001;31(6):528-535. (Pubitemid 32579390)
18. Moriyasu F, Nishida O, Ban N, et al. "Congestion index" of the portal vein. AJR Am J Roentgenol 1986;146(4):735-739.
19. Sheth SG, Flamm SL, Gordon FD, Chopra S. AST/ALT ratio predicts cirrhosis in patients with chronic hepatitis C virus infection. Am J Gastroenterol 1998;93(1):44-48. (Pubitemid 29065511)
20. Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology 2003;38(2):518-526. (Pubitemid 36919874)
21. Sterling RK, Lissen E, Clumeck N, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology 2006;43(6):1317-1325. (Pubitemid 43980111)
22. Ozaki K, Matsui O, Kobayashi S, et al. Selective atrophy of the middle hepatic venous drainage area in hepatitis C-related cirrhotic liver: morphometric study by using multidetector CT. Radiology 2010;257(3): 705-714.
23. Pinzani M, Gentilini P. Biology of hepatic stellate cells and their possible relevance in the pathogenesis of portal hypertension in cirrhosis. Semin Liver Dis 1999;19(4): 397-410. (Pubitemid 30032641)
24. Bosch J, Garcia-Pagan JC. Pathophysiology of portal hypertension and its complications. In: Bircher J, Benhamou JP, McIntyre N, Rizzetto M, Rodes J, eds. Oxford textbook of clinical hepatology. 2nd ed. Vol 1. New York, NY : Oxford University Press, 1999; 653-660.
25. Wiest R, Groszmann RJ. The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough. Hepatology 2002;35(2):478-491. (Pubitemid 34110432)
26. Gupta TK, Toruner M, Chung MK, Groszmann RJ. Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats. Hepatology 1998;28(4):926-931. (Pubitemid 28450251)
27. Merriman RB, Ferrell LD, Patti MG, et al. Correlation of paired liver biopsies in morbidly obese patients with suspected nonalcoholic fatty liver disease. Hepatology 2006; 44(4):874-880. (Pubitemid 46489551)
28. Bolognesi M, Sacerdoti D, Merkel C, et al. Splenic Doppler impedance indices: influence of different portal hemodynamic conditions. Hepatology 1996;23(5):1035-1040. (Pubitemid 26137043)
29. Liu CH, Hsu SJ, Liang CC, et al. Esophageal varices: noninvasive diagnosis with duplex Doppler US in patients with compensated cirrhosis. Radiology 2008;248(1):132-139.
30. Osada Y, Kanazawa H, Narahara Y, Mamiya Y, Nakatsuka K, Sakamoto C. Wedged hepatic venous pressure does not reflect portal pressure in patients with cirrhosis and hepatic veno-venous communications. Dig Dis Sci 2008;53(1):7-13. (Pubitemid 50007602)
31. Berzigotti A, Zappoli P, Magalotti D, Tiani C, Rossi V, Zoli M. Spleen enlargement on follow-up evaluation: a noninvasive predictor of complications of portal hypertension in cirrhosis. Clin Gastroenterol Hepatol 2008; 6(10):1129-1134.
32. Bolognesi M, Merkel C, Sacerdoti D, Nava V, Gatta A. Role of spleen enlargement in cirrhosis with portal hypertension. Dig Liver Dis 2002;34(2):144-150. (Pubitemid 34202075)
33. de Franchis R. Evolving consensus in portal hypertension: report of the Baveno IV consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 2005;43(1):167-176.
34. Garcia-Tsao G, Sanyal AJ, Grace ND, Carey W;Practice Guidelines Committee of the American Association for the Study of Liver Diseases;Practice Parameters Committee of the American College of Gastroenterology . Prevention and management of gastroesophageal varices and variceal hemorrhage in cirrhosis. Hepatology 2007; 46(3):922-938. (Pubitemid 47436138)