Chemical development of an α2δ ligand, (3 S,5 R)-3-(Aminomethyl)-5-methyloctanoic acid

Organic Process Research and Development

Volumn 15, Issue 6, 2011, Pages 1315-1327

  Murtagh, Lorraine ^a   Dunne, Catherine ^a   Gabellone, Gino ^a   Panesar, Niamh J ^a   Field, Stuart ^a   Reeder, Lisa M ^b   Saenz, James ^b   Smith, George P ^b   Kissick, Kyle ^b   Martinez, Carlos ^b   Van Alsten, John G ^b   Evans, Margaret C ^b   Franklin, Lloyd C ^b   Nanninga, Thomas ^b   Wong, John ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID EQUIVALENTS; CHEMICAL DEVELOPMENT; DIASTEREOSELECTIVE; KINETIC RESOLUTION; LARGE SCALE MANUFACTURE; MANUFACTURING PROCESS; PROCESS OPTIMISATION; SALIENT FEATURES; SYNTHETIC APPROACH;

AMINO ACIDS; MANUFACTURE; OPTIMIZATION;

LIGANDS;

EID: 81555209857     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op2001832     Document Type: Article

References (12)

1. Satzinger, G.; Hartenstein, J.; Herrmann, M.; Heldt, W. Ger. Offen. DE 246089, 1976.
2. Silverman, R. B.; Andruszkiewicz, R.; Nanavati, S. M.; Taylor, C. P.; Vartanian, M. G. J. Med. Chem. 1991, 34, 2295
3. Dooley, D. J.; Taylor, C. P.; Donevan, S.; Feltner, D. Trends Pharmacol. Sci. 2007, 28, 75
4. Yuen, P.-W. The Art of Drug Synthesis; Johnson, D. S.; Li, J. J., Eds.; Wiley: New York, 2007; p 225.
5. Aiyer, L. P.; Brown, P. K.; Gajda, P. A.; Mastrell, C. E. J. PCT Int. Appl. WO/2009/136375 A1, 2009.
6. Hoekstra, M. S.; Sobieray, D. M.; Schwindt, M. A.; Mulhern, T. A.; Grote, T. M.; Huckabee, B. K.; Hendrickson, V. S.; Franklin, L. C.; Granger, E. J.; Karrick, G. L. Org. Process Res. Dev. 1997, 1, 26
7. Evans, D. A.; Ennis, M. D.; Mathre, D. J. J. Am. Chem. Soc. 1982, 104, 1737
8. Gooding, O. W.; Voladri, R.; Bautista, A.; Hopkins, T.; Huisman, G.; Jenne, S.; Ma, S.; Mundorff, E. C.; Savile, M. M.; Truesdell, S. J.; Wong, J. W. Org. Process Res. Dev. 2010, 14, 119
9. Krapcho, A.; Paul; Weimaster, J. F.; Eldridge, J. M.; Jahngen, E. G. E., Jr.; Lovey, A. J.; Stephens, W. P. J. Org. Chem. 1978, 43 (1) 138
10. Urban, P. G.; Pitt, M. J., Compiler. Brethericks Handbook of Reactive Chemical Hazards, 7 th ed.; Butterworth Heinemann: Boston; 1999; Vol. 1, entry 0917, dimethylsulfoxide.
11. Yazbeck, D. R.; Tao, J.; Martinez, C. A.; Kline, B. J.; Hu, S. Adv. Synth. Catal. 2003, 345, 524
12. BHymer, C; Montes-Bayon, M; Caruso, J. A. J. Sep. Sci. 2003, 26, 7