Paradigm shift in treatment of Alzheimer's disease: Zinc therapy now a conscientious choice for care of individual patients

International Journal of Alzheimer's Disease

Volumn , Issue , 2011, Pages

  Hoogenraad, Tjaard U ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER; PENICILLAMINE; PLACEBO; WILSON DISEASE PROTEIN; ZINC; ZINC SULFATE;

ALZHEIMER DISEASE; AMYLOIDOSIS; CHELATION THERAPY; COPPER METABOLISM; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG EXCRETION; DRUG FATALITY; DRUG SAFETY; EVIDENCE BASED MEDICINE; GENETIC ANALYSIS; HEART INFARCTION; HUMAN; LOW DRUG DOSE; NERVE DEGENERATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PATIENT CARE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; TREATMENT OUTCOME; WILSON DISEASE;

EID: 81555207171     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2011/492686     Document Type: Review

References (37)

1. Hoogenraad T. U., Paradigm shift in treatment of Wilson's disease: zinc therapy now treatment of choice Brain and Development 2006 28 3 141 146 (Pubitemid 43326232)
2. Nestor P. J., Scheltens P., Hodges J. R., Advances in the early detection of Alzheimer's disease Nature Medicine 2004 10 S34 S41
3. Hoogenraad T., Wilsons Disease 2001 Amsterdam, The Netherlands Intermed Medical Publishers
4. Chutkow J. G., Evidence for uptake of nonceruloplasminic copper in the brain: effect of ionic copper and amino acids Proceedings of the Society for Experimental Biology and Medicine 1978 158 1 113 116 (Pubitemid 8375724)
5. Choi B. S., Zheng W., Copper transport to the brain by the blood-brain barrier and blood-CSF barrier Brain Research 2009 1248 14 21
6. Squitti R., Ventriglia M., Barbati G., Cassetta E., Ferreri F., Dal Forno G., Ramires S., Zappasodi F., Rossini P. M., 'Free' copper in serum of Alzheimer's disease patients correlates with markers of liver function Journal of Neural Transmission 2007 114 12 1589 1594 (Pubitemid 350212005)
7. Giambattistelli F., Bucossi S., Salustri C., Panetta V., Mariani S., Siotto M., Ventriglia M., Vernieri F., Dell'Acqua M. L., Cassetta E., Rossini P. M., Squitti R., Effects of hemochromatosis and transferrin gene mutations on iron dyshomeostasis, liver dysfunction and on the risk of Alzheimer's disease. Neurobiology of Aging. In press
8. Ren H., Ji Q., Liu Y., Ru B., Different protective roles in vitro of -and -domains of growth inhibitory factor (GIF) on neuron injuries caused by oxygen free radicals Biochimica et Biophysica Acta 2001 1568 2 129 134 (Pubitemid 34025102)
9. Hoogenraad T. U., Monograph: Wilson's disease Major Problems in Neurology 1996 30 London, UK WB Saunders
10. Hoogenraad T. U., Kompoliti K., Verhagen Metman L., Wilson's disease Encyclopedia of Movement Disorders 2010 3 Oxford, UK Academic Press 335 340
11. Squitti R., Pasqualetti P., Dal Forno G., Moffa F., Cassetta E., Lupoi D., Vernieri F., Rossi L., Baldassini M., Rossini P. M., Excess of serum copper not related to ceruloplasmin in Alzheimer disease Neurology 2005 64 6 1040 1046 (Pubitemid 40388458)
12. Capo C. R., Arciello M., Squitti R., Cassetta E., Rossini P. M., Calabrese L., Rossi L., Features of ceruloplasmin in the cerebrospinal fluid of Alzheimer's disease patients BioMetals 2008 21 3 367 372
13. Squitti R., Barbati G., Rossi L., Ventriglia M., Dal Forno G., Cesaretti S., Moffa F., Caridi I., Cassetta E., Pasqualetti P., Calabrese L., Lupoi D., Rossini P. M., Excess of nonceruloplasmin serum copper in AD correlates with MMSE, CSF -amyloid, and h-tau Neurology 2006 67 1 76 82 (Pubitemid 44305465)
14. Squitti R., Cassetta E., Dal Forno G., Lupoi D., Lippolis G., Pauri F., Vernieri F., Cappa A., Rossini P. M., Copper perturbation in 2 monozygotic twins discordant for degree of cognitive impairment Archives of Neurology 2004 61 5 738 743 (Pubitemid 38637692)
15. Squitti R., Bressi F., Pasqualetti P., Bonomini C., Ghidoni R., Binetti G., Cassetta E., Moffa F., Ventriglia M., Vernieri F., Rossini P. M., Longitudinal prognostic value of serum free copper in patients with Alzheimer disease Neurology 2009 72 1 50 55
16. Squitti R., Ghidoni R., Scrascia F., Benussi L., Panetta V., Pasqualetti P., Moffa F., Bernardini S., Ventriglia M., Binetti G., Rossini P. M., Free copper distinguishes mild cognitive impairment subjects from healthy elderly individuals Journal of Alzheimer's Disease 2011 23 2 239 248
17. Arnal N., Cristalli D. O., de Alaniz M. J. T., Marra C. A., Clinical utility of copper, ceruloplasmin, and metallothionein plasma determinations in human neurodegenerative patients and their first-degree relatives Brain Research 2010 1319 118 130
18. Brewer G. J., Kanzer S. H., Zimmerman E. A., Celmins D. F., Heckman S. M., Dick R., Copper and ceruloplasmin abnormalities in Alzheimers disease American Journal of Alzheimer's Disease and other Dementias 2010 25 6 490 497
19. Danzeisen R., Araya M., Harrison B., Keen C., Solioz M., Thiele D., Mcardle H. J., How reliable and robust are current biomarkers for copper status? British Journal of Nutrition 2007 98 4 676 683 (Pubitemid 47487934)
20. Hellman N. E., Gitlin J. D., Ceruloplasmin metabolism and function Annual Review of Nutrition 2002 22 439 458 (Pubitemid 35221468)
21. Schouwink G., De hepatocerebrale degeneratie, met een onderzoek naar de koperstofwisseling, Ph.D. thesis 1961 University of Amsterdam
22. Newsome D. A., A randomized, prospective, placebo-controlled clinical trial of a novel zinc-monocysteine compound in age-related macular degeneration Current Eye Research 2008 33 7 591 598 (Pubitemid 351948491)
23. Masad A., Hayes L., Tabner B. J., Turnbull S., Cooper L. J., Fullwood N. J., German M. J., Kametani F., El-Agnaf O. M. A., Allsop D., Copper-mediated formation of hydrogen peroxide from the amylin peptide: a novel mechanism for degeneration of islet cells in type-2 diabetes mellitus? FEBS Letters 2007 581 18 3489 3493 (Pubitemid 47048200)
24. Liu G., Garrett M. R., Men P., Zhu X., Perry G., Smith M. A., Nanoparticle and other metal chelation therapeutics in Alzheimer disease Biochimica et Biophysica Acta 2005 1741 3 246 252 (Pubitemid 41338670)
25. Squitti R., Rossini P. M., Cassetta E., Moffa F., Pasqualetti P., Cortesi M., Colloca A., Rossi L., Finazzi-Agr A., D-penicillamine reduces serum oxidative stress in Alzheimer's disease patients European Journal of Clinical Investigation 2002 32 1 51 59 (Pubitemid 36228383)
26. Ritchie C. W., Bush A. I., Mackinnon A., Macfarlane S., Mastwyk M., MacGregor L., Kiers L., Cherny R., Li Q. X., Tammer A., Carrington D., Mavros C., Volitakis I., Xilinas M., Ames D., Davis S., Beyreuther K., Tanzi R. E., Masters C. L., Metal-protein attenuation with iodochlorhydroxyquin (Clioquinol) targeting A amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial Archives of Neurology 2003 60 12 1685 1691 (Pubitemid 37521621)
27. Lannfelt L., Blennow K., Zetterberg H., Batsman S., Ames D., Harrison J., Masters C. L., Targum S., Bush A. I., Murdoch R., Wilson J., Ritchie C. W., Safety, efficacy, and biomarker findings of PBT2 in targeting A as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial The Lancet Neurology 2008 7 9 779 786
28. Constantinidis J., Treatment of Alzheimer's disease by zinc compounds Drug Development Research 1992 27 1 1 14
29. Bucossi S., Ventriglia M., Panetta V., Salustri C., Pasqualetti P., Mariani S., Siotto M., Rossini P. M., Squitti R., Copper in alzheimer's disease: a meta-analysis of serum,plasma, and cerebrospinal fluid studies Journal of Alzheimer's Disease 2011 24 1 175 185
30. Bucossi S., Ventriglia M., Polimanti R., Association between the c.2495 AG ATP7B Polymorphism and Sporadic Alzheimer's Disease International Journal of Alzheimer's Disease 2011 2011 9
31. Ewers M., Cheng X., Nural H. F., Increased CSF- BACE1 activity associated with decreased hippocampus volume in Alzheimer's disease Journal of Alzheimer's Disease 2011 25 2 373 381
32. Mossello E., Ballini E., Mello A. M., Tarantini F., Simoni D., Baldasseroni S., Marchionni N., Biomarkers of Alzheimer's disease: from central nervous system to periphery? International Journal of Alzheimer's Disease 2011 2011 7
33. Klunk W. E., Engler H., Nordberg A., Wang Y., Blomqvist G., Holt D. P., Bergstrm M., Savitcheva I., Huang G. F., Estrada S., Ausén B., Debnath M. L., Barletta J., Price J. C., Sandell J., Lopresti B. J., Wall A., Koivisto P., Antoni G., Mathis C. A., Lngstrm B., Imaging brain amyloid in Alzheimer's disease with pittsburgh compound-B Annals of Neurology 2004 55 3 306 319 (Pubitemid 38269583)
34. Morris M. C., Evans D. A., Tangney C. C., Bienias J. L., Schneider J. A., Wilson R. S., Scherr P. A., Dietary copper and high saturated and trans fat intakes associated with cognitive decline Archives of Neurology 2006 63 8 1085 1088 (Pubitemid 44232313)
35. Lam P. K., Kritz-Silverstein D., Barrett-Connor E., Milne D., Nielsen F., Gamst A., Morton D., Wingard D., Plasma trace elements and cognitive function in older men and women: the Rancho Bernardo study Journal of Nutrition, Health and Aging 2008 12 1 22 27 (Pubitemid 351156011)
36. Luo L., Boerwinkle E., Xiong M., Association studies for next-generation sequencing Genome Research 2011 21 7 1099 1108
37. De La Vega F. M., Bustamante C. D., Leal S. M., Genome-wide association mapping and rare alleles: from population genomics to personalized medicine Pacific Symposium on Biocomputing 2011 74 75