Gender differences, polypharmacy, and potential pharmacological interactions in the elderly

Clinics

Volumn 66, Issue 11, 2011, Pages 1867-1872

  Venturini, Carina Duarte ^a   Engroff, Paula ^a   Ely, Luísa Scheer ^a   de Araújo Zago, Luísa Faria ^a   Schroeter, Guilherme ^a   Gomes, Irenio ^a   de Carli, Geraldo Attilio ^a   Morrone, Fernanda Bueno ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Drug drug; Hazards; Interaction; Older adults; Pharmacology; Polytherapy

Indexed keywords

AGE DISTRIBUTION; AGED; ARTICLE; BRAZIL; DRUG INTERACTION; FEMALE; HUMAN; MALE; MIDDLE AGED; PHYSIOLOGY; POLYPHARMACY; RETROSPECTIVE STUDY; SEX RATIO;

AGE DISTRIBUTION; AGED; AGED, 80 AND OVER; BRAZIL; DRUG INTERACTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYPHARMACY; RETROSPECTIVE STUDIES; SEX DISTRIBUTION;

EID: 81555202007     PISSN: 18075932     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1807-59322011001100004     Document Type: Article

References (39)

1. Christensen K, Doblhammer G, Rau R, Vaupel JW. Ageing populations: the challenges ahead. Lancet. 2009;374:1196-2083, doi: 10.1016/S0140- 6736(09)61460-4.
2. World Health Organization. Aging and life course; 2009. Available from: URL: http://www.who.int/ageing/en/index.html [Accessed 2010 Sep 02].
3. S. Prevalence, associated factors, and misuse of medication in the elderly: a review. Cad Saude Publica. 2003;19:717-24, doi: 10.1590/ S0102-311X2003000300004.
4. Frankfort SV, Tulner LR, van Campen JP, Koks CH, Beijnen JH. Evaluation of pharmacotherapy in geriatric patients after performing complete geriatric assessment at a diagnostic day clinic. Clin Drug Investig. 2006;26:169-74, doi: 10.2165/00044011-200626030-00007.
5. Vonbach P, Dubied A, Krähenbühl S, Beer JH. Prevalence of drug-drug interactions at hospital entry and during hospital stay of patients in internal medicine. Eur J Intern Med. 2008;19:413-20, doi: 10.1016/j.ejim. 2007.12.002.
6. Brownie S. Why are elderly individuals at risk of nutritional deficiency? Int J Nurs Pract. 2006;12:110-8, doi: 10.1111/j.1440-172X.2006.00557.x.
7. Rademaker M. Do women have more adverse drug reactions? Am J Clin Dermatol. 2001;2:349-51, doi: 10.2165/00128071-200102060-00001.
8. Faggiani FT, Schroeter G, Pacheco SL, Souza ACA, Werlang MC, De Carli GA, et al. Profile of drug utilization in the elderly living in Porto Alegre, Brazil. Pharm Pract. 2007;5:179-84.
9. Instituto Brasileiro de Geografia e Estatística. Available from: URL: http://www.ibge.gov.br [Accessed 2010 Aug 03].
10. Magro L, Conforti A, Del Zotti F, Leone R, Iorio ML, Meneghelli I, et al. Identification of severe potential drug-drug interactions using an Italian general-practitioner database. Eur J Clin Pharmacol. 2008;64:303-9, doi: 10.1007/s00228-007-0394-1.
11. World Health Organization; 2004. Anatomical-Therapeutic-Chemical Classification. Available from: URL: http://www.whocc.no/atcddd [Accessed 2010 Jul 12].
12. Reis AM, Cassiani SH. Prevalence of potential drug interactions in patients in an intensive care unit of a university hospital in Brazil. Clinics (Sao Paulo). 2011;66:9-15.
13. MicromedexH Healthcare Series. Greenwood Village (CO): Thomson Reuters (Healthcare) Inc., 2007. Available from URL: https://www.thomsonhc.com/hcs/librarian/[Accessed 2010 Jul 5].
14. Linjakumpu T, Hartikainen S, Klaukka T, Veijola J, Kivelä SL, Isoaho R. Use of medications and polypharmacy are increasing among the elderly. J Clin Epidemiol. 2002;55:809-17, doi: 10.1016/S0895-4356(02)00411-0.
15. Moen J, Bohm A, Tillenius T, Antonov K, Nilsson JL, Ring L. "I don't know how many of these [medicines] are necessary."- a focus group study among elderly users of multiple medicines. Patient Educ Couns. 2009;74:135-41, doi: 10.1016/j.pec.2008.08.019.
16. Flores LM, Mengue SS. Drug use by the elderly in Southern Brazil. Rev Saude Publica. 2005;39:924-9, doi: 10.1590/S0034-89102005000600009.
17. Zaitune MP, Barros MB, César CL, Carandina L, Goldbaum M. Arterial hypertension in the elderly: prevalence, associated factors, and control practices in Campinas, São Paulo, Brazil. Cad Saude Publica. 2006;22:285-94, doi: 10.1590/S0102-311X2006000200006.
18. Gijsber van Wijk CMT, Kolk AM, van den Bosch WJHM, van den Hoogen HJ. Male and female morbidity in general practice: the nature of sex differences. Soc Sci Med. 1992;35:665-78, doi: 10.1016/0277-9536(92)90005-B.
19. Suominen-Taipale AL, Martelin T, Koskinen S, Holmen J, Johnsen R. Gender differences in health care use among the elderly population in areas of Norway and Finland. A cross-sectional analysis based on the HUNT study and the FINRISK Senior Survey. BMC Health Serv Res. 2006;6:110, doi: 10.1186/1472-6963-6-110.
20. Phillips SL, Carr-Lopez SM. Impact of a pharmacist on medication discontinuation in a hospital-based geriatric clinic. Am J Hosp Pharm. 1990;47:1075-9.
21. Green JL, Hawley JN, Rask KJ. Is the number of prescribing physicians an independent risk factor for adverse drug events in an elderly outpatient population? Am J Geriatr Pharmacother. 2007;5:31-9, doi: 10. 1016/j.amjopharm.2007.03.004.
22. Tulner LR, Kuper IM, Frankfort SV, van Campen JP, Koks CH, Brandjes DP, et al. Discrepancies in reported drug use in geriatric outpatients: relevance to adverse events and drug-drug interactions. Am J Geriatr Pharmacother. 2009;7:93-104, doi: 10.1016/j.amjopharm.2009.04.006.
23. Instituto Brasileiro de Geografia e Estatística. Breves notas sobre a mortalidade no Brasil no período 1991/2007. Rio de Janeiro: 2008.
24. AI. Comparative assessment of four drug interaction compendia. Br J Clin Pharmacol. 2007;63:709-14, doi: 10.1111/j.1365-2125.2006.02809. x.
25. Schroeter G, Chaves LL, Engroff P, Faggiani FT, De Carli GA, Morrone FB. Estudo de Utilização de Anti-Ulcerosos na População Idosa de Porto Alegre, RS, Brasil. Rev HCPA. 2008;28:89-95.
26. World Health Organization. International Society of Hypertension (ISH). Guidelines for the management of hypertension. J Hypert. 1999;17:151-83.
27. Seymour RM, Routledg PA. Important Drug-drug interactions in the elderly. Drugs Aging. 1998;12:485-94, doi: 10.2165/00002512-199812060- 00006.
28. Terleira A, Portoles A, Rojas A, Vargas E. Effect of drug-test interactions on length of hospital stay. Pharmacoepidemiol Drug Saf. 2007;16:39-45, doi: 10.1002/pds.1330.
29. Moura C, Acurcio F, Belo N. Drug-drug interactions associated with length of stay and cost of hospitalization. J Pharm Pharm Sci. 2009;2:266-72.
30. Gomez R, Venturini CD. Interação entre alimentos e medicamentos. Porto Alegre: Suliani Letra e Vida. 2009.p.64
31. Molden E, Skovlund E, Braathen P. Risk management of simvastatin or atorvastatin interactions with CYP3A4 inhibitors. Drug Saf. 2008;31:587-96, doi: 10.2165/00002018-200831070-00004.
32. Jacobson TA. Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors. Am J Cardiol. 2004;94:1140-6, doi: 10.1016/j. amjcard.2004.07.080.
33. Fenster PE, Hager WD, Goodman MM. Digoxin-quinidine-spironolactone interaction. Clin Pharmacol Ther. 1984;36:70-3, doi: 10.1038/clpt. 1984.141.
34. Nobili A, et al. Potentially severe drug interactions in elderly outpatients: results of an observational study of an administrative prescription database. J Clin Pharm Ther. 2009;34:377-86, doi: 10.1111/j.1365-2710. 2009.01021.x.
35. Lin CF, Wang CY, Bai CH. Polypharmacy, aging and potential drugdrug interactions in outpatients in Taiwan: a retrospective computerized screening study. Drugs Aging. 2011;28:219-25, doi: 10.2165/11586870-000000000-00000.
36. Chrischilles EA, Foley DJ, Wallace RB, Lemke JH, Semla TP, Hanlon JT, et al. Use of medications by persons 65 and over: data from the established populations for epidemiologic studies of the elderly. J Gerontol. 1992;47:137-44.
37. Wortmann AC, Grüdtner MC, Fialho AF, Jardim Neto JC, Schaefer LG, Sehn F, et al. Consumo de benzodiazepínicos em Porto Alegre. Rev Assoc Med Bras. 1994;40:265-70.
38. Schwartz JB. The influence of sex on pharmacokinetics. Clin Pharmacokinet. 2003;42:107-21, doi: 10.2165/00003088-200342020-00001.
39. Rozenfeld S, Pepe VLE. Guia Terapêutico Ambulatorial. Porto Alegre: Artes Médicas; 1992.