Pilot plant preparation of tert-butyl-4-(2-hydroxyethyl)-4-(pyrrolidin-1- yl)-piperidine-1-carboxylate, an intermediate of novel antiarteriosclerotics, via a safe, scalable reformatsky-type reaction

Organic Process Research and Development

Volumn 15, Issue 6, 2011, Pages 1433-1437

  Osato, Hiroshi ^a   Osaki, Motonari ^a   Oyama, Takao ^a   Takagi, Youhei ^a   Hida, Takemasa ^a   Nishi, Koichi ^a   Kabaki, Mikio ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMINIUM SALTS; KEYPOINTS; REFORMATSKY REACTION; REFORMATSKY-TYPE REACTIONS; SAFE PROCESS; TRIFLUOROACETIC ACIDS;

CARBOXYLATION; PILOT PLANTS;

REACTION INTERMEDIATES;

EID: 81555201666     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op2001723     Document Type: Article

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