Preventive effect of GGsTop, a novel and selective γ-glutamyl transpeptidase inhibitor, on ischemia/reperfusion-induced renal injury in rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 339, Issue 3, 2011, Pages 945-951

  Yamamoto, Shinya ^a   Watanabe, Bunta ^b   Hiratake, Jun ^b   Tanaka, Ryosuke ^a   Ohkita, Mamoru ^a   Matsumura, Yasuo ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 4 [[3 (CARBOXYMETHYL)PHENYL](METHYL)PHOSPHONO]BUTANOIC ACID; CREATININE; ENZYME INHIBITOR; GAMMA GLUTAMYLTRANSFERASE; GAMMA GLUTAMYLTRANSPEPTIDASE INHIBITOR; GLUTATHIONE; MALONALDEHYDE; SODIUM; SUPEROXIDE; UNCLASSIFIED DRUG; UREA;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; HISTOPATHOLOGY; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; KIDNEY ISCHEMIA; KIDNEY MEDULLA; KIDNEY TUBULE NECROSIS; KIDNEY VEIN; MALE; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL ARTERY; RENAL PROTECTION; REPERFUSION INJURY; SODIUM BLOOD LEVEL; SODIUM EXCRETION; UREA NITROGEN BLOOD LEVEL;

ACUTE KIDNEY INJURY; AMINOBUTYRIC ACIDS; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GAMMA-GLUTAMYLTRANSFERASE; GLUTATHIONE; KIDNEY FUNCTION TESTS; MALE; MALONDIALDEHYDE; MOLECULAR TARGETED THERAPY; OXYGEN; PHOSPHONIC ACIDS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SUPEROXIDES; TIME FACTORS;

EID: 81555195495     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.183004     Document Type: Article

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