The amount of astrocytic GABA positively correlates with the degree of tonic inhibition in hippocampal CA1 and cerebellum

Molecular Brain

Volumn 4, Issue 1, 2011, Pages

  Yoon, Bo Eun ^a,b   Jo, Seonmi ^a,c   Woo, Junsung ^a,b   Lee, Jae Hoon ^a   Kim, Taekeun ^a   Kim, Daesoo ^c   Lee, C Justin ^a,b  

^a Korea Institute of Science and Technology   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; BESTROPHIN 1 CHANNEL; PROTEIN; UNCLASSIFIED DRUG; 3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BICUCULLINE; EYE PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; HYBRID PROTEIN; ION CHANNEL; PYRIDAZINE DERIVATIVE; VMD2 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN REGION; CEREBELLUM; GABAERGIC SYSTEM; GLIA CELL; GRANULE CELL; HIPPOCAMPAL CA1 REGION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; THALAMUS; TONIC INHIBITION; ANIMAL; C57BL MOUSE; CYTOLOGY; GENETICS; METABOLISM; NERVE CELL INHIBITION; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; ASTROCYTES; BICUCULLINE; CA1 REGION, HIPPOCAMPAL; CEREBELLUM; EYE PROTEINS; GABA-A RECEPTOR ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLIAL FIBRILLARY ACIDIC PROTEIN; ION CHANNELS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURAL INHIBITION; PYRIDAZINES; RECOMBINANT FUSION PROTEINS;

EID: 81455160588     PISSN: None     EISSN: 17566606     Source Type: Journal    
DOI: 10.1186/1756-6606-4-42     Document Type: Article

References (22)

1. Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Farrant M, Nusser Z, Nature reviews Neuroscience 2005 6 3 215 229 10.1038/nrn1625 15738957 (Pubitemid 40342416)
2. Integration of quanta in cerebellar granule cells during sensory processing. Chadderton P, Margrie TW, Hausser M, Nature 2004 428 6985 856 860 10.1038/nature02442 15103377 (Pubitemid 38529500)
3. Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors. Caraiscos VB, Elliott EM, You-Ten KE, Cheng VY, Belelli D, Newell JG, Jackson MF, Lambert JJ, Rosahl TW, Wafford KA, et al. Proceedings of the National Academy of Sciences of the United States of America 2004 101 10 3662 3667 10.1073/pnas.0307231101 14993607 (Pubitemid 38338251)
4. Enhanced tonic GABAA inhibition in typical absence epilepsy. Cope DW, Di Giovanni G, Fyson SJ, Orban G, Errington AC, Lorincz ML, Gould TM, Carter DA, Crunelli V, Nature medicine 2009 15 12 1392 1398 10.1038/nm.2058 19966779
5. GABAA receptor-mediated tonic inhibition in thalamic neurons. Cope DW, Hughes SW, Crunelli V, The Journal of neuroscience 2005 25 50 11553 11563 10.1523/JNEUROSCI.3362-05.2005 16354913 (Pubitemid 43098448)
6. Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity. Hanchar HJ, Dodson PD, Olsen RW, Otis TS, Wallner M, Nature neuroscience 2005 8 3 339 345 10.1038/nn1398 15696164 (Pubitemid 40300191)
7. Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors. Brickley SG, Cull-Candy SG, Farrant M, The Journal of physiology 1996 497 Pt 3 753 759 9003560
8. An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neurons. Jia F, Pignataro L, Schofield CM, Yue M, Harrison NL, Goldstein PA, Journal of neurophysiology 2005 94 6 4491 4501 10.1152/jn.00421.2005 16162835 (Pubitemid 41691802)
9. Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. Nusser Z, Mody I, Journal of neurophysiology 2002 87 5 2624 2628 11976398 (Pubitemid 34670732)
10. Tonically active GABA A receptors: modulating gain and maintaining the tone. Semyanov A, Walker MC, Kullmann DM, Silver RA, Trends in neurosciences 2004 27 5 262 269 10.1016/j.tins.2004.03.005 15111008 (Pubitemid 38529954)
11. Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons. Stell BM, Mody I, The Journal of neuroscience 2002 22 10 C223 12006605
12. Molecular basis for the GABAA receptor-mediated tonic inhibition in rat somatosensory cortex. Yamada J, Furukawa T, Ueno S, Yamamoto S, Fukuda A, Cereb Cortex 2007 17 8 1782 1787 16997904 (Pubitemid 47216495)
13. Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke. Clarkson AN, Huang BS, Macisaac SE, Mody I, Carmichael ST, Nature 2010 468 7321 305 309 10.1038/nature09511 21048709
14. The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus. Glykys J, Mody I, The Journal of physiology 2007 582 Pt 3 1163 1178 17525114 (Pubitemid 47104346)
15. Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons. Bai D, Zhu G, Pennefather P, Jackson MF, MacDonald JF, Orser BA, Molecular pharmacology 2001 59 4 814 824 11259626 (Pubitemid 32274010)
16. GABA uptake regulates cortical excitability via cell type-specific tonic inhibition. Semyanov A, Walker MC, Kullmann DM, Nature neuroscience 2003 6 5 484 490 12679782 (Pubitemid 36514696)
17. Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors. Stell BM, Brickley SG, Tang CY, Farrant M, Mody I, Proceedings of the National Academy of Sciences of the United States of America 2003 100 24 14439 14444 10.1073/pnas.2435457100 14623958 (Pubitemid 37499255)
18. Channel-mediated tonic GABA release from glia. Lee S, Yoon BE, Berglund K, Oh SJ, Park H, Shin HS, Augustine GJ, Lee CJ, Science 2010 330 6005 790 796 10.1126/science.1184334 20929730
19. Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes. Park H, Oh SJ, Han KS, Woo DH, Mannaioni G, Traynelis SF, Lee CJ, The Journal of neuroscience 2009 29 41 13063 13073 10.1523/JNEUROSCI.3193-09. 2009 19828819
20. Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABA. Yeung JY, Canning KJ, Zhu G, Pennefather P, MacDonald JF, Orser BA, Molecular pharmacology 2003 63 1 2 8 10.1124/mol.63.1.2 12488530 (Pubitemid 36043802)
21. Segregation of different GABAA receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. Nusser Z, Sieghart W, Somogyi P, The Journal of neuroscience 1998 18 5 1693 1703 9464994 (Pubitemid 28103077)
22. Extrasynaptic alphabeta subunit GABAA receptors on rat hippocampal pyramidal neurons. Mortensen M, Smart TG, The Journal of physiology 2006 577 Pt3 841 856 17023503 (Pubitemid 44873650)