Telomere length and cardiovascular risk in hypertensive patients with left ventricular hypertrophy: The LIFE study

Journal of Human Hypertension

Volumn 25, Issue 12, 2011, Pages 711-718

  Fyhrquist, F ^a   Silventoinen, K ^b   Saijonmaa, O ^a   Kontula, K ^a   Devereux, R B ^c   De Faire, U ^d   Os, I ^e   Dahlof B ^f  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

^e ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^f SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cardiovascular diseases; Coronary artery disease; Telomeres; Transient ischemic attack

Indexed keywords

ADULT; AGED; ANGINA PECTORIS; ARTICLE; CARDIOVASCULAR RISK; CEREBROVASCULAR DISEASE; CORONARY ARTERY DISEASE; FEMALE; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL (TOPIC); STROKE; TELOMERE; TRANSIENT ISCHEMIC ATTACK;

AGED; AGED, 80 AND OVER; ANTIHYPERTENSIVE AGENTS; ATENOLOL; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; COMORBIDITY; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; HYPERTROPHY, LEFT VENTRICULAR; LEUKOCYTES; LOSARTAN; MALE; MIDDLE AGED; RISK FACTORS; TELOMERE; TREATMENT OUTCOME;

EID: 81455158996     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/jhh.2011.57     Document Type: Article

References (28)

1. Blackburn EH. Switching and signaling at the telomere. Cell 2001; 106: 661-667.
2. Blasco MA. Telomeres and human disease: ageing, cancer, and beyond. Nat Rev Genet 2005; 6: 611-622. (Pubitemid 41044298)
3. Benetos A, Okuda K, Lajemi M, Kimura M, Thomas F, Skurnick J et al. Telomere length as an indicator of biological aging: the gender effect and relation with pulse pressure and pulse wave velocity. Hypertension 2001; 37: 381-385. (Pubitemid 32198997)
4. Jeanclos E, Schork NJ, Kyvik KO, Kimura M, Skurnick JH, Aviv A. Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension 2000; 36: 195-200. (Pubitemid 30626988)
5. Martin-Ruiz CM, Gussekloo J, van Heemst D, von Zglinicki T, Westendorp RGJ. Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell 2005; 4: 287-290.
6. Schönland SO, Lopez C, Widmann T, Zimmer J, Beryl E, Goony JJ et al. Premature telomere loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages. Proc Natl Acad Sci USA 2003; 100: 13471-13476. (Pubitemid 37444766)
7. Samani NJ, Boultby R, Butler R, Thompson JR, Goodall AH. Telomere shortening in atherosclerosis. Lancet 2001; 358: 472-473. (Pubitemid 32769858)
8. Fitzpatrick AL, Kronmal RA, Gardner JP, Psaty BM, Jenny NS, Tracy RP et al. Leukocyte telomere length and cardiovascular disease in the Cardiovascular Health Study. Am J Epidemiol 2007; 165: 14-21. (Pubitemid 46026204)
9. Yang Z, Huang X, Jiang H, Zhang Y, Liu H, Qin C et al. Short telomeres and prognosis of hypertension in a Chinese population. Hypertension 2009; 53: 639-645.
10. Fyhrquist F, Tiitu A. Saijonmaa O, Forsblom C, Groop PH, on behalf of the FinnDiane Study Group. Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes. J Intern Med 2010; 267: 278-286.
11. Dahlö f B, Devereux R, Kjeldsen SE, Julius S, Beevers G, de Faire U et al. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002; 359: 995-1003. (Pubitemid 34286536)
12. Hemann MT, Strong MA, Hao LY, Greider CW. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 2001; 107: 67-77. (Pubitemid 32972038)
13. Zou Y, Sfeir A, Gryaznov SM, Shay JW, Wright WE. Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell 2004; 15: 3709-3718 (Pubitemid 38989708)
14. Minamino T, Miyauchi M, Yoshida T, Ishida Y, Yoshida H, Komuro I. Endothelial cell senescence in human atherosclerosis. Role of telomere in endothelial dysfunction. Circulation 2002; 105: 1541-1544. (Pubitemid 34297628)
15. Brouilette S, Singh RK, Thompson JR, Goodall AH, Samani NJ. White cell telomere length and risk of premature myocardial infarction. Arterioscler Thromb Vasc Biol 2003; 23: 842-846. (Pubitemid 36566175)
16. Kimura M, von Hjelmborg I, Gardner JP, Bathum L, Brimacombe M, Lu X et al. Telomere length and mortality: a study of leukocytes in elderly Danish twins. Am J Epidemiol 2008; 167: 799-806. (Pubitemid 351451747)
17. Cawthon R, Smith K, O'Brien E, Sivatchenko A, Kerber R. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 2003; 361: 393-395. (Pubitemid 36164975)
18. von Zglinicki T. Oxidative stress shortens telomeres. TRENDS Biochem Sci 2002; 27: 339-344. (Pubitemid 34756516)
19. Valdes AM, Andrew T, Gardner JP, Kimura M, Oelsner E, Cherkas LF et al. Obesity, cigarette smoking, and telomere length in women. Lancet 2005; 366: 662-664. (Pubitemid 41176019)
20. Cherkas LF, Aviv A, Valdes Am Hunkin JL, Gardner JP, Surdulescu GL, Kimura M et al. The effects of social status on biological aging as measured by white-blood-cell telomere length. Aging Cell 2006; 5: 361-365. (Pubitemid 44322531)
21. Aviv A, Chen W, Gardner JP, Kimura M, Brimacombe M, Cao X et al. Leukocyte telomere dynamics: longitudinal findings among young adults in the Bogalusa Heart Study. Am J Epidemiol 2009; 169: 323-329.
22. Bekaert S, De Meyer T, Rietzschel ER, De Buyzere ML, De Bacquer D, Langlois M et al. Telomere length and cardiovascular risk factors in a middle-aged population free of overt cardiovascular disease. Aging Cell 2007; 6: 639-647. (Pubitemid 47400046)
23. Nordfjäll K, Eliasson M, Stegmayr B, Melander O, Nilsson P, Roos G. Telomere length is associated with obesity parameters but with a gender difference. Obesity 2008; 16: 2682-2689.
24. Aviv A. The epidemiology of human telomeres: faults and promises. J Gerontol 2008; 63A: 979-983.
25. Andrew T, Aviv A, Falchi M, Surdulescu GL, Gardner JP, Lu X et al. Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected sibling pairs. Am J Hum Genet 2006; 78: 480-486. (Pubitemid 43291229)
26. Cherkas LF, Hunkin JL, Kato BS, Richards JB, Gardner JP, Surdulescu GL et al. The association between physical activity in leisure and leukocyte telomeric length. Arch Intern Med 2008; 168: 154-158. (Pubitemid 351185881)
27. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA 2004; 101: 17323-17324.
28. Vasan RS, Demissie S, Kimura M, Cupples LA, White C, Gardner JP et al. Association of leukocyte telomere length with echocadiographic left ventricular mass. The Framingham Heart Study. Circulation 2009; 120: 1195-1202.