Molecular diagnostics in periprosthetic joint infection

International Journal of Artificial Organs

Volumn 34, Issue 9, 2011, Pages 847-855

  Parviz, Javad ^a   Walinchus, Lesley ^a   Adeli, Bahar ^a  

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

C reactive protein; Joint arthroplasty; Leukocyte esterase; Periprosthetic join infection; Synovial fluid aspirate

Indexed keywords

BLOOD; ESTERS;

C-REACTIVE PROTEINS; JOINT ARTHROPLASTY; LEUCOCYTE ESTERASE; LEUCOCYTES; MOLECULAR DIAGNOSTICS; MOLECULAR MARKER; ORTHOPEDIC COMMUNITY; PERIPROSTHETIC JOIN INFECTION; SYNOVIAL FLUID; SYNOVIAL FLUID ASPIRATE;

ENZYMES;

C REACTIVE PROTEIN; ESTERASE; LEUKOCYTE ENZYME; MOLECULAR MARKER;

ARTHROPLASTY; DEBRIDEMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE SEDIMENTATION RATE; HUMAN; INFECTIOUS ARTHRITIS; JOINT ASPIRATION; JOINT PROSTHESIS; LEUKOCYTE COUNT; MOLECULAR DIAGNOSIS; PERIPROSTHETIC JOINT INFECTION; PREDICTIVE VALUE; PROSTHESIS INFECTION; RECEIVER OPERATING CHARACTERISTIC; REVIEW; SENSITIVITY AND SPECIFICITY; SYNOVIAL FLUID; WOUND IRRIGATION;

EID: 81355163353     PISSN: 03913988     EISSN: None     Source Type: Journal    
DOI: 10.5301/ijao.5000054     Document Type: Review

References (35)

1. Della Valle CJ, Zuckerman JD, Di Cesare PE. Periprosthetic Sepsis. Clin Orthop Relat Res. 2004;420(420):26-31. doi:10.1097/00003086-200403000-00005.
2. Duff GP, Lachiewicz PF, Kelley SS. Aspiration of the knee joint before revision arthroplasty. Clin Orthop Relat Res. 1996;331(331):132-139. doi:10.1097/00003086-199610000-00018.
3. Peersman G, Laskin R, Davis J, Peterson M. Infection in total knee replacement: a retrospective review of 6489 total knee replacements. Clin Orthop Relat Res. 2001;392(392):15-23. doi:10.1097/00003086-200111000-00003.
4. Phillips JE, Crane TP, Noy M, Elliott TS, Grimer RJ. The incidence of deep prosthetic infections in a specialist orthopaedic hospital: A 15-year prospective survey. J Bone Joint Surg Br. 2006;88-B(7):943-948. doi:10.1302/0301-620X.88B7.17150.
5. Parvizi J, Ghanem E, Azzam K, Davis E, Jaberi F, Hozack W. Periprosthetic infection: are current treatment strategies adequate? Acta Orthop Belg. 2008;74(6):793-800.
6. Sculo TP. The economic impact of infected total joint arthroplasty. Instr Course Lect. 1993;42:349-351.
7. Bauer TW, Parvizi J, Kobayashi N, Krebs V. Diagnosis of periprosthetic infection. J Bone Joint Surg Am. 2006;88(4):869-882. doi:10.2106/JBJS.E.01149.
8. Berbari EF, Hanssen AD, Duffy MC, et al. Risk factors for prosthetic joint infection: case-control study. Clin Infect Dis. 1998;27(5):1247-1254. doi:10.1086/514991.
9. Parvizi J, Ghanem E, Menashe S, Barrack RL, Bauer TW. Periprosthetic infection: what are the diagnostic challenges? J Bone Joint Surg Am. 2006;88(Suppl 4):138-147. doi:10.2106/JBJS.F.00609.
10. Parvizi J, Ghanem E, Sharkey P, Aggarwal A, Burnett RSJ, Barrack RL. Diagnosis of infected total knee: findings of a multicenter database. Clin Orthop Relat Res. 2008;466(11):2628-2633. doi:10.1007/s11999-008-0471-5.
11. Schinsky MF, Della Valle CJ, Sporer SM, Paprosky WG. Perioperative testing for joint infection in patients undergoing revision total hip arthroplasty. J Bone Joint Surg Am. 2008;90(9):1869-1875. doi:10.2106/JBJS.G.01255.
12. Spangehl MJ, Masri BA, O'Connell JX, Duncan CP. Prospective analysis of preoperative and intraoperative investigations for the diagnosis of infection at the sites of two hundred and two revision total hip arthroplasties. J Bone Joint Surg Am. 1999;81(5):672-683.
13. Trampuz A, Piper KE, Jacobson MJ, et al. Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med. 2007;357(7):654-663. doi:10.1056/NEJMoa061588.
14. Abdul-Karim FW, McGinnis MG, Kraay M, Emancipator SN, Goldberg V. Frozen section biopsy assessment for the presence of polymorphonuclear leukocytes in patients undergoing revision of arthroplasties. Mod Pathol. 1998;11(5):427-431.
15. Lachiewicz PF, Rogers GD, Thomason HC. Aspiration of the hip joint before revision total hip arthroplasty. Clinical and laboratory factors influencing attainment of a positive culture. J Bone Joint Surg Am. 1996;78(5):749-754.
16. Lonner JH, Desai P, Dicesare PE, Steiner G, Zuckerman JD. The reliability of analysis of intraoperative frozen sections for identifying active infection during revision hip or knee arthroplasty. J Bone Joint Surg Am. 1996;78(10):1553-1558.
17. Mirra JM, Marder RA, Amstutz HC. The pathology of failed total joint arthroplasty. Clin Orthop Relat Res. 1982;(170):175-183.
18. Padgett DE, Silverman A, Sachjowicz F, Simpson RB, Rosen berg AG, Galante JO. Efficacy of intraoperative cultures obtained during revision total hip arthroplasty. J Arthroplasty. 1995;10(4):420-426. doi:10.1016/S0883-5403(05)80140-8.
19. Athanasou NA, Pandey R, de Steiger R, Crook D, Smith PM. Diagnosis of infection by frozen section during revision arthroplasty. J Bone Joint Surg Br. 1995;77(1):28-33.
20. Fehring TK, McAlister JA Jr. Frozen histologic section as a guide to sepsis in revision joint arthroplasty. Clin Orthop Relat Res. 1994;(304):229-237.
21. Feldman DS, Lonner JH, Desai P, Zuckerman JD. The role of intraoperative frozen sections in revision total joint arthroplasty. J Bone Joint Surg Am. 1995;77(12):1807-1813.
22. Pandey R, Berendt AR, Athanasou NA; The OSIRIS Collaborative Study Group. Oxford Skeletal Infection Research and Intervention Service. Histological and microbiological findings in non-infected and infected revision arthroplasty tissues. Arch Orthop Trauma Surg. 2000;120(10):570-574. doi:10.1007/s004020000174.
23. Tunney MM, Patrick S, Gorman SP, et al. Improved detection of infection in hip replacements: A currently underestimated problem. J Bone Joint Surg Br. 1998;80(4):568-572. doi:10.1302/0301-620X.80B4.8473.
24. Bozic KJ, Ries MD. The impact of infection after total hip arthroplasty on hospital and surgeon resource utilization. J Bone Joint Surg Am. 2005;87(8):1746-1751. doi:10.2106/JBJS.D.02937.
25. Ghanem E, Antoci V Jr, Pulido L, Joshi A, Hozack W, Parvizi J. The use of receiver operating characteristics analysis in determining erythrocyte sedimentation rate and C-reactive protein levels in diagnosing periprosthetic infection prior to revision total hip arthroplasty. Int J Infect Dis. 2009;13(6):e444-e449. doi:10.1016/j.ijid.2009.02.017.
26. Trampuz A, Hanssen AD, Osmon DR, Mandrekar J, Steckelberg JM, Patel R. Synovial fluid leukocyte count and differen tial for the diagnosis of prosthetic knee infection. Am J Med. 2004;117(8):556-562. doi:10.1016/j.amjmed.2004.06.022.
27. Parvizi J, Jacovides C, Zmistowski B, Jung KA. Definition of periprosthetic joint infection: is there a consensus? Clin Orthop Relat Res. 2011;469(11):3022-3030.
28. Jacovides CL, Parvizi J, Adeli B, Jung KA. Molecular Markers for Diagnosis of Periprosthetic Joint Infection. J Arthroplasty 2011;26(6 Suppl):99-103.
29. Deirmengian C, Hallab N, Tarabishy A, et al. Synovial fluid biomarkers for periprosthetic infection. Clin Orthop Relat Res. 2010;468(8):2017-2023. doi:10.1007/s11999-010-1298-4.
30. Bedair H, Ting N, Jacovides C, et al. The Mark Coventry Award: diagnosis of early postoperative TKA infection using synovial fluid analysis. Clin Orthop Relat Res. 2011;469(1):34-40. doi:10.1007/s11999-010-1433-2.
31. Della Valle CJ, Sporer SM, Jacobs JJ, Berger RA, Rosenberg AG, Paprosky WG. Preoperative testing for sepsis before revision total knee arthroplasty. J Arthroplasty. 2007;22(6) (Suppl 2):90-93. doi:10.1016/j.arth.2007.04.013.
32. Mason JB, Fehring TK, Odum SM, Griffin WL, Nussman DS. The value of white blood cell counts before revision total knee arthroplasty. J Arthroplasty. 2003;18(8):1038-1043. doi:10.1016/S0883-5403(03)00448-0.
33. Ghanem E, Parvizi J, Burnett RSJ, et al. Cell count and differential of aspirated fluid in the diagnosis of infection at the site of total knee arthroplasty. J Bone Joint Surg Am. 2008;90(8):1637-1643. doi:10.2106/JBJS.G.00470.
34. Parvizi J, Jacovides C, Adeli B, Jung KA, Hozack W. CRP in joints: a molecular marker for periprosthetic joint infection? J Arthroplasty. In press.
35. Parvizi J, Jacovides C, Antoci V, Ghanem E. Diagnosis of periprosthetic joint infection: the role of a simple, yet unrecognized, enzyme. J Arthroplasty. In Press.