Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes

Journal of Cell Science

Volumn 124, Issue 21, 2011, Pages 3568-3580

  Wang, Yin ^a   Bruce, Allen T ^a   Tu, Caixia ^b   Ma, Keli ^a   Zeng, Li ^a   Zheng, Pan ^a   Liu, Yang ^a   Liu, Yan ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Darier disease; ER stress; Keratinocyte; SERCA2 aggregation

Indexed keywords

CALCIUM; MUTANT PROTEIN; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM DEPLETION; CELL ADHESION; CELL COUNT; CONTROLLED STUDY; DARIER DISEASE; ENDOPLASMIC RETICULUM STRESS; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; KERATINOCYTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; SOLUBILITY; UBIQUITINATION;

ANIMALS; APOPTOSIS; CELLS, CULTURED; DARIER DISEASE; ENDOPLASMIC RETICULUM STRESS; HUMANS; KERATINOCYTES; MICE; MICE, INBRED C57BL; MUTATION; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; SOLUBILITY;

EID: 81355161230     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.084053     Document Type: Article

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