Glucocorticoids suppress corneal lymphangiogenesis

Cornea

Volumn 30, Issue 12, 2011, Pages 1442-1447

  Steele, Maria M ^a   Kelley, Philip M ^a   Schieler, Amanda M ^a   Tempero, Richard M ^a  

^a BOYS TOWN NATIONAL RESEARCH HOSPITAL   (United States)

Author keywords

cornea; glucocorticoid; inflammatio; lymphangiogenesis

Indexed keywords

COLLAGEN; DEXAMETHASONE; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORNEAL LYMPHANGIOGENESIS; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; LYMPH VESSEL ENDOTHELIUM; LYMPHANGIOGENESIS; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELLS, CULTURED; DEXAMETHASONE; ENDOTHELIAL CELLS; ENDOTHELIUM, CORNEAL; ENDOTHELIUM, VASCULAR; GLUCOCORTICOIDS; HUMANS; LYMPHANGIOGENESIS; MICE; MODELS, ANIMAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 81355148829     PISSN: 02773740     EISSN: 15364798     Source Type: Journal    
DOI: 10.1097/ICO.0b013e318213f39f     Document Type: Article

References (11)

1. Tabbara KF. Pharmacologic strategies in the prevention and treatment of corneal transplant rejection. Int Ophthalmol. 2008;28:223-232.
2. Klebe S, Coster DJ, Williams KA. Rejection and acceptance of corneal allografts. Curr Opin Organ Transplant. 2009;14:4-9.
3. Tammela T, Alitalo K. Lymphangiogenesis: molecular mechanisms and future promise. Cell. 2010;140:460-476.
4. Cursiefen C, Chen L, Dana MR, et al. Corneal lymphangiogenesis: evidence, mechanisms, and implications for corneal transplant immunology. Cornea. 2003;22:273-281.
5. Boneham GC, Collin HB. Steroid inhibition of limbal blood and lymphatic vascular cell growth. Curr Eye Res. 1995;14:1-10.
6. Yao LC,Baluk P, Feng J, et al. Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways. Am J Pathol. 2010; 176: 1525-1541.
7. Cursiefen C, Maruyama K, Jackson DG, et al. Time course of angiogenesis and lymphangiogenesis after brief corneal inflammation. Cornea. 2006;25:443-447.
8. Maruyama K, Ii M, Cursiefen C, et al. Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J Clin Invest. 2005;115:2363-2372.
9. Bachmann BO, Luetjen-Drecoll E, Bock F, et al. Transient postoperative vascular endothelial growth factor (VEGF)-neutralisation improves graft survival in corneas with partly regressed inflammatory neovascularization. Br J Ophthalmol. 2009;93:1075-1080.
10. Dietrich T, Bock F, Yuen D, et al. Cutting edge: lymphatic vessels, not blood vessels, primarily mediate immune rejections after transplantation. J Immunol. 2010;184:535-539.
11. Baluk P, Tammela T, Ator E, et al. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest. 2005; 115:247-257.