Prevalence of congenital cytomegalovirus infection in Slovenia: A study on 2,841 newborns

Journal of Medical Virology

Volumn 84, Issue 1, 2012, Pages 109-115

  Paradiž, Katarina Rednak ^a   Seme, Katja ^b   Puklavec, Evelin ^c   Paro Panjan, Darja ^d   Poljak, Mario ^b  

^a General Hospital Slovenj Gradec   (Slovenia)

^b UNIVERSITY OF LJUBLJANA   (Slovenia)

^c UNIVERSITY MEDICAL CENTRE MARIBOR   (Slovenia)

^d UNIVERSITY CHILDREN S HOSPITAL   (Slovenia)

Author keywords

Congenital infection; Cytomegalovirus; PCR; Screening; Slovenia

Indexed keywords

VIRUS DNA;

ARTICLE; BIRTH; BLOOD ANALYSIS; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; DRIED BLOOD SPOTS; EASTERN EUROPE; FEMALE; HEALTH CARE COST; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; NEWBORN; NEWBORN PERIOD; NEWBORN SCREENING; NONHUMAN; PLASMA; PREVALENCE; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; SCREENING; SLOVENIA; URINALYSIS; VIRUS ISOLATION;

CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; FEMALE; HUMANS; INFANT, NEWBORN; MALE; MASS SCREENING; PLASMA; PREVALENCE; PROSPECTIVE STUDIES; REAL-TIME POLYMERASE CHAIN REACTION; SLOVENIA; URINE;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5;

EID: 81355138380     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.22230     Document Type: Article

References (50)

1. Ahlfors K, Ivarsson SA, Harris S. 1999. Report on a long-term study of maternal and congenital cytomegalovirus infection in Sweden. Review of prospective studies available in the literature. Scand J Infect Dis 31: 443-457.
2. Allain JP. 2000. Genomic screening for blood-borne viruses in transfusion settings. Clin Lab Haematol 22: 1-10.
3. American Academy of Pediatrics, Joint Committee on Infant Hearing. 2007. Year 2007 position statement: Principles and guidelines for early hearing detection and intervention programs. Pediatrics 120: 898-921.
4. American Speech-Language-Hearing Association. 2004. Guidelines for the audiologic assessment of children from birth to 5 years of age [guidelines]. Available from.
5. Atkinson C, Walter S, Sharland M, Tookey P, Luck S, Peckham C, Griffiths P. 2009. Use of stored dried blood spots for retrospective diagnosis of congenital CMV. J Med Virol 81: 1394-1398.
6. Barbi M, Binda S, Primache V, Clerici D. 1998. Congenital cytomegalovirus infection in a northern Italian region. NEOCMV Group. Eur J Epidemiol 14: 791-796.
7. Barbi M, Binda S, Primache V, Caroppo S, Didò P, Guidotti P, Corbetta C, Melotti D. 2000. Cytomegalovirus DNA detection in Guthrie cards: A powerful tool for diagnosing congenital infection. J Clin Virol 17: 159-165.
8. Barbi M, Binda S, Caroppo S, Calvario A, Germanario C, Tanzi ML, Veronesi L, Mura I, Piana A, Solinas G, Pugni L, Bevílaqua G, Mosca F. 2006. Multicity Italian study of congenital cytomegalovirus infection. Pediatr Infect Dis J 25: 156-159.
9. Boppana SB, Fowler KB, Pass RF, Rivera LB, Bradford RD, Lakeman FD, Britt WJ. 2005. Congenital cytomegalovirus infection: Association between virus burden in infancy and hearing loss. J Pediatr 146: 817-823.
10. Boppana SB, Ross SA, Novak Z, Shimamura M, Tolan RW, Palmer AL, Ahmed A, Michaels MG, Sanchez PJ, Bernstein DL, Britt WJ, Fowler KB, National Institute on Deafness Other Communication Disorders CHIMES Study. 2010. Dried blood spot real-time polymerase chain reaction assays to screen newborns for congenital cytomegalovirus infection. JAMA 303: 1375-1382.
11. Boppana SB, Ross SA, Shimamura M, Palmer AL, Ahmed A, Michaels MG, Sánchez PJ, Bernstein DI, Tolan RW, Jr., Novak Z, Chowdhury N, Britt WJ, Fowler KB, National Institute on Deafness Other Communication Disorders CHIMES Study. 2011. Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newborns. N Engl J Med 364: 2111-2118.
12. Bristow BN, O'Keefe KA, Shafir SC, Sorvillo FJ. 2011. Congenital cytomegalovirus mortality in the United States, 1990-2006. PLoS Negl Trop Dis 5: e1140.
13. Cannon MJ, Hyde TB, Schmid DS. 2011. Review of cytomegalovirus shedding in bodily fluids and relevance to congenital cytomegalovirus infection. Rev Med Virol 21: 240-255.
14. de Vries JJ, Vossen AC, Kroes AC. 2010. Screening newborns for congenital cytomegalovirus infection. JAMA 304: 407.
15. Dollard SC, Schleiss MR. 2010. Screening newborns for congenital cytomegalovirus infection. JAMA 304: 407-408.
16. Endo T, Goto K, Ito K, Sugiura T, Terabe K, Cho S, Nishiyama M, Sugiyama K, Togari H. 2009. Detection of congenital cytomegalovirus infection using umbilical cord blood samples in screening survey. J Med Virol 81: 1773-1776.
17. Engman M, Malm G, Engstrom L, Petersson K, Karltrop E, Tear Fahnehjelm K, Uhlen I, Guthenberg C, Lewensohn-Fuchs I. 2008. Congenital cytomegalovirus infection: Prevalence in newborns and the impact on hearing deficit. Scand J Infect Dis 40: 935-942.
18. Foulon I, Naessens A, Foulon W, Casteels A, Gordts F. 2008. A 10-year prospective study of sensorineural hearing loss in children with congenital cytomegalovirus infection. J Pediatr 153: 84-88.
19. Fowler KB, McCollister FP, Dahle AJ, Boppana S, Britt WJ, Pass RF. 1997. Progressive and fluctuating sensorineural hearing loss in children with asymptomatic congenital cytomegalovirus infection. J Pediatr 130: 624-630.
20. Gaytant MA, Galama JM, Semmekrot BA, Melchers WJ, Sporken JM, Oosterbaan HP, van Dop PA, Huisman A, Merkus HM, Steegers EA. 2005. The incidence of congenital cytomegalovirus infections in the Netherlands. J Med Virol 76: 71-75.
21. Gleaves CA, Smith TF, Shuster EA, Pearson GR. 1984. Rapid detection of cytomegalovirus in MRC-5cells inoculated with urine specimens by using low-speed centrifugation and monoclonal antibody to an early antigen. J Clin Microbiol 19: 917-919.
22. Grosse SD, Ross DS, Dollard SC. 2008. Congenital cytomegalovirus (CMV) infection as a cause of permanent bilateral hearing loss: A quantitative assessment. J Clin Virol 41: 57-62.
23. Halwachs-Baumann G, Genser B, Pailer S, Engele H, Rosegger H, Schalk A, Kessler HH, Truschnig-Wilders M. 2002. Human cytomegalovirus load in various body fluids of congenitally infected newborns. J Clin Virol 25: S81-S87.
24. Halwaschs-Baumann G, Genser B, Danda M, Engele H, Rosegger H, Folsch B, Murer U, Lackner H, Truschnig-Wilders M. 2000. Screening and diagnosis of congenital cytomegalovirus infection: A 5 year study. Scand J Infect Dis 32: 137-142.
25. Inoue N, Koyano S. 2008. Evaluation of screening tests for Congenital cytomegalovirus infection. Pediatr Infect Dis J 27: 182-184.
26. Johansson PJ, Jönsson M, Ahlfors K, Ivarsson SA, Svanberg L, Guthenberg C. 1997. Retrospective diagnostics of congenital cytomegalovirus infection performed by polymerase chain reaction in blood stored on filter paper. Scand J Infect Dis 29: 465-468.
27. Kamada M, Komori A, Chiba S, Nakao T. 1983. A prospective study of congenital cytomegalovirus infection in Japan. Scand J Infect Dis 15: 227-232.
28. Kenneson A, Cannon MJ. 2007. Review and meta-analysis of the epidemiology of congenital CMV infection. Vaccine 19: 253-276.
29. Kharrazi M, Hyde T, Young S, Amin MM, Cannon MJ, Dollard SC. 2010. Use of screening dried blood spots for estimation of prevalence, risk factors, and birth outcomes of congenital cytomegalovirus infection. J Pediatr 157: 191-197.
30. Leruez-Ville M, Vauloup-Fellous C, Couderc S, Parat S, Castel C, Avettand-Fenoel V, Guilleminot T, Grangeot-Keros L, Ville Y, Grabar S, Magny JF. 2011. Prospective identification of congenital cytomegalovirus infection in newborns using real-time polymerase chain reaction assays in dried blood spots. Clin Infect Dis 52: 575-581.
31. Mine H, Emura H, Miyamoto M, Tomono T, Minegishi K, Murokawa H, Yamanaka R, Yoshikawa A, Nishioka K, Japanese Red Cross NAT Research Group. 2003. High throughput screening of 16 million serologically negative blood donors for hepatitis B virus, hepatitis C virus and human immunodeficiency virus type-1 by nucleic acid amplification testing with specific and sensitive multiplex reagent in Japan. J Virol Methods 112: 145-151.
32. Mussi-Pinhata MM, Yamamoto AY, Moura Brito RM, Isaac M, Carvalho e Oliveira PF, Boppana S, Britt WJ. 2009. Birth prevalence and natural history of congenital cytomegalovirus infection in a higly seroimmune population. Clin Inf Dis 49: 522-528.
33. Numazaki K, Fujikawa T. 2004. Chronological changes of incidence and prognosis of children with asymptomatic congenital cytomegalovirus infection in Sapporo, Japan. BMC Infect Dis 4: 22.
34. Owens JJ, McCoy MJ, Lonsbury-Martin BL, Martin GK. 1993. Otoacoustic emissions in children with normal ears, middle ear dysfunction, and ventilating tubes. Am J Otol 14: 34-40.
35. Paixão P, Almeida S, Gouveia P, Binda S, Caroppo S, Barbi M. 2005. Diagnosis of congenital cytomegalovirus infection by detection of viral DNA in urine pools. J Virol Methods 128: 1-5.
36. Paixão P, Almeida S, Videira PA, Ligeiro D, Marques T. 2011. Screening of congenital cytomegalovirus infection by real-time PCR in urine pools. Eur J Pediatr May 26 [Epub ahead of print].
37. Paro-Panjan D, Neubauer D, Kodrič J, Bratanič B. 2005. Amiel-Tison neurological assessment at term age: Clinical application, correlation with other methods, and outcome at 12 to 15 months. Dev Med Child Neurol 47: 19-26.
38. Pass RF, Stagno S, Britt WJ, Alford CA. 1983. Specific cell-mediated immunity and the natural history of congenital infection with cytomegalovirus. J Infect Dis 148: 953-961.
39. Roth WK, Weber M, Buhr S, Drosten C, Weichert W, Sireis W, Hedges D, Seifried E. 2002. Yield of HCV and HIV-1 NAT after screening of 3.6 million blood donations in central Europe. Transfusion 42: 862-868.
40. Schleiss MR. 2008. Congenital cytomegalovirus infection: Update on management strategies. Curr Treat Options Neurol 10: 186-192.
41. Schlesinger Y, Halle D, Eidelman AI, Reich D, Dayan D, Rudensky B, Raveh D. 2003. Urine polymerase chain reaction as a screening tool for detection of congenital cytomegalovirus infection. Arch Dis Child Fetal Neonatal Ed 88: 371-374.
42. Seme K, Močilnik T, Poljak M. 2011. Twenty-four mini-pool HCV RNA screening in a routine clinical virology laboratory setting: A six-year prospective study. J Virol Methods 171: 303-305.
43. Soetens O, Vauloupot-Fellous C, Foulon I, Dubreuil P, De Saeger B, Grangeot-Keros L, Naessens A. 2008. Evaluation of different cytomegalovirus (CMV) DNA PCR protocols for analysis of dried blood spots from consecutive cases of neonates with congenital CMV infection. J Clin Microbiol 46: 943-946.
44. Stramer SL, Glynn SA, Kleinman SH, Strong DM, Caglioti S, Wright DJ, Dodd RY, Busch MP, National Heart, Lung Blood, Institute Nucleic, Acid Test, Study Group. 2004. Detection of HIV-1 and HCV infections among antibody negative blood donors by nucleic acid-amplification testing. N Engl J Med 351: 760-768.
45. Syggelou A, Iacovidou N, Kloudas S, Christoni Z, Papaevangelou V. 2010. Congenital cytomegalovirus infection. Ann NY Acad Sci 1205: 144-147.
46. Vaudry W, Rosychuk RJ, Lee BE, Cheung PY, Pang X, Preiksaitis JK. 2010. Congenital cytomegalovirus infection in high-risk Canadian infants: Report of a pilot screening study. Can J Infect Dis Med Microbiol 21: e12-e19.
47. Yamagashi Y, Miyagawa H, Wada K, Matsumoto S, Arahori H, Tamura A, Taniguchi H, Kanekiyo T, Sashihara J, Yoda T, Kitagawa M, Ozono K. 2006. CMV detection in dried blood spoots for diagnosing congenital cytomegalovirus infection in Japan. J Med Virol 78: 923-925.
48. Yamamoto AY, Mussi-Pinhata MM, Pinto PC, Figueiredo LT, Jorge SM. 2001. Usefulness of blood and urine samples collected on filter paper in detecting cytomegalovirus by the polymerase chain reaction technique. J Virol Methods 97: 159-164.
49. Yamamoto AY, Mussi-Pinhata MM, Marin LJ, Brito RM, Oliveira PF, Coelho TB. 2006. Is saliva as reliable as urine for detection of cytomegalovirus DNA for neonatal screening of congenital CMV infection? J Clin Virol 36: 228-230.
50. Yan H, Koyano S, Inami Y, Yamamoto Y, Suzutani T, Mizuguchi M, Ushijima H, Kurane I, Inoue N. 2008. Genetic variations in the gB, UL144 and UL149 genes of human cytomegalovirus strains collected from congenitally and postnatally infected Japanese children. Arch Virol 153: 667-674.