Continuous ultra-low-intensity artificial daylight is not as effective as red LED light in photodynamic therapy of multiple actinic keratoses

Photodermatology Photoimmunology and Photomedicine

Volumn 27, Issue 6, 2011, Pages 280-285

  Wiegell, Stine Regin ^a   Heydenreich, Jakob ^a   Fabricius, Susanne ^a   Wulf, Hans Christian ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Actinic keratoses; Daylight; Light intensity; Methyl aminolevulinate; Photodynamic therapy

Indexed keywords

AMINOLEVULINIC ACID METHYL ESTER;

ACTINIC KERATOSIS; ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; FACE; FEMALE; HUMAN; ILLUMINATION; INTERMETHOD COMPARISON; LIGHT EMITTING DIODE; LIGHT INTENSITY; MALE; PAIN ASSESSMENT; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; SCALP; SCANDINAVIA; SUNLIGHT; TREATMENT RESPONSE; WINTER;

ADOLESCENT; ADULT; AMINOLEVULINIC ACID; FEMALE; HUMANS; KERATOSIS, ACTINIC; LIGHT; MALE; MIDDLE AGED; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; TIME FACTORS;

EID: 81355124122     PISSN: 09054383     EISSN: 16000781     Source Type: Journal    
DOI: 10.1111/j.1600-0781.2011.00611.x     Document Type: Article

References (12)

1. Morton CA, McKenna KE, Rhodes LE. Guidelines for topical photodynamic therapy: update. Br J Dermatol 2008; 159: 245-266.
2. Wiegell SR, Hædersdal M, Philipsen PA, Eriksen P, Enk CD, Wulf HC. Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses - a randomized, controlled, single-blinded study. Br J Dermatol 2008; 158: 740-746.
3. Wiegell SR, Hædersdal M, Eriksen P, Wulf HC. Photodynamic therapy of actinic keratoses with 8% and 16% methyl aminolevulinate and home-based daylight exposure: a double-blinded randomized clinical trial. Br J Dermatol 2009; 160: 1308-1314.
4. Wiegell SR, Fabricius S, Stender I-M etal. A randomized, multicentre study of directed daylight exposure times of 11/2 vs. 21/2h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalp. Br J Dermatol 2011; 164: 1083-1090.
5. Szeimies RM, Karrer S, Radakovic-Fijan S etal. Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratoses: a prospective, randomized study. J Am Acad Dermatol 2002; 47: 258-262.
6. Heydenreich J, Wulf HC. Miniature personal electronic UVR dosimeter with erythema response and time-stamped readings in a wristwatch. Photochem Photobiol 2005; 81: 1138-1144.
7. Olsen EA, Abernethy ML, Kulp-Shorten C etal. A double blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck. J Am Acad Dermatol 1991; 24: 738-743.
8. Morton C, Campbell S, Gupta G etal. Intraindividual, right-left comparison of topical ethyl aminolevulinate-photodynamic therapy and cryotherapy in subjects with actinic keratoses: a multicenter randomized controlled study. Br J Dermatol 2006; 155: 1029-1036.
9. Tarstedt M, Tosdahl I, Berne B, Svanberg K, Wenneberg AM. A randomized multicenter study to compare two treatment regimes of topical methyl aminolevulinate (Metvix®)-PDT in actinic keratosis of the face and scalp. Acta Derm Venereol 2005; 85: 424-428.
10. Johnsen J, Christoffersen J. Daylight in rooms and buildings, 1st edn. Hørsholm, Denmark: Danish Building Research Institute, 2008. Guidelines 219.
11. Thieden E, Ågren MS, Wulf HC. The wrist is a reliable body site for personal dosimetry of ultraviolet radiation. Photodermatol Photoimmunol Photomed 2000; 16: 57-61.
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