Exquisite synthesis of a designed PAR-1 antagonist

Helvetica Chimica Acta

Volumn 94, Issue 11, 2011, Pages 1981-1993

  Miao, Hua Ming ^a,b   Zhao, Gui Long ^b   Zhang, Lin Shan ^c   Shao, Hua ^b   Wang, Jian Wu ^a  

^a SHANDONG UNIVERSITY   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

^c QINGDAO UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antiplatelet activity; Hydrogenolysis; PAR 1 Antagonist

Indexed keywords

ANTI-PLATELET ACTIVITIES; ELECTRON-RICH; PAR-1 ANTAGONIST; STERICALLY CONGESTED; TETRAZOLES;

ALDEHYDES; HYDROGENOLYSIS;

HYDROLYSIS;

1 [3 (TERT BUTYL) 4 METHOXY 5 (MORPHOLIN 4 YL)PHENYL] 2 (5,6 DIETHOXY 1,3 DIHYDRO 3 IMINO 1,1 DIMETHYL 2H ISOINDOL 2 YL)ETHANONE HYDROBROMIDE; 1 BROMO 4,5 DIETHOXY 2 (1 METHYLETHENYL)BENZENE; 2 (1 AZIDO 1 METHYLETHYL) 4,5 DIETHOXYBENZONITRILE; 2 (1,3 DIOXOLAN 2 YL) 4,5 DIETHOXYBENZONITRILE; 2 (2 BROMO 4,5 DIETHOXYPHENYL) 1,3 DIOXOLANE; 2 (2 BROMO 4,5 DIETHOXYPHENYL)PROPAN 2 OL; 2 [2 (AMINOMETHYL) 4,5 DIETHOXYPHENYL]PROPAN 2 OL; 2 BROMO 4,5 DIETHOXYBENZALDEHYDE; 3,4 DIETHOXYBENZALDEHYDE; 3,4 DIETHOXYBENZOIC ACID; 4,5 DIETHOXY 2 (1 METHYLETHENYL)BENZONITRILE; 4,5 DIETHOXY 2 FORMYLBENZONITRILE; 5,6 AIETHOXY 3,3 DIMETHYL 2 BENZOFURAN 1(3H) ONE; 5,6 DIETHOXY 2,3 DIHYDRO 3,3 DIMETHYL 1H ISOINDOL 1 IMINE; 5,6 DIETHOXY 3,3 DIMETHYL 2 BENZOFURAN 1(3H) IMINE; 7,8 DIETHOXY 5,5 DIMETHYL 5H TETRAZOL[5,1 A]ISOINDOLE; ALKENE; AMIDINE; ANTITHROMBOCYTIC AGENT; ATOPAXAR; BENZALDEHYDE; ETHYL 2 BROMO 4,5 DIETHOXYBENZOATE; ETHYL 2 CYANO 4,5 DIETHOXYBENZOATE; ETHYL 3,4 DIETHOXYBENZOATE; PROTEINASE ACTIVATED RECEPTOR 1; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ELECTRON; HYDROGENOLYSIS; IN VITRO STUDY; OXIDATION; PRIORITY JOURNAL; SYNTHESIS;

EID: 81255214576     PISSN: 0018019X     EISSN: 15222675     Source Type: Journal    
DOI: 10.1002/hlca.201100128     Document Type: Article

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