Genome-wide association study of circulating retinol levels

Human Molecular Genetics

Volumn 20, Issue 23, 2011, Pages 4724-4731

  Mondul, Alison M ^a   Yu, Kai ^a   Wheeler, William ^c   Zhang, Hong ^d   Weinstein, Stephanie J ^a   Major, Jacqueline M ^a   Cornelis, Marilyn C ^e   Männistö, Satu ^f   Hazra, Aditi ^e   Hsing, Ann W ^a   Jacobs, Kevin B ^b,g   Eliassen, Heather ^h   Tanaka, Toshiko ⁱ   Reding, Douglas J ^j   Hendrickson, Sara ^e   Ferrucci, Luigi ⁱ   Virtamo, Jarmo ^f   Hunter, David J ^e   Chanock, Stephen J ^b   Kraft, Peter ^e   Albanes, Demetrius ^a   more..

^a Department of Health and Human Services ^*  (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c INFORMATION MANAGEMENT SERVICES INC   (United States)

^d FUDAN UNIVERSITY   (China)

^e HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^f NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^g BioInformed LLC   (United States)

^h BRIGHAM AND WOMEN S HOSPITAL   (United States)

ⁱ NATIONAL INSTITUTE ON AGING   (United States)

^j MARSHFIELD CLINIC   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; PREALBUMIN; RETINOL; RETINOL BINDING PROTEIN 4;

ADULT; AGED; ARTICLE; CANCER RISK; CAUCASIAN; COHORT ANALYSIS; COLORECTAL CANCER; CONTROLLED STUDY; FEMALE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; VITAMIN BLOOD LEVEL;

AGED; CHROMOSOMES, HUMAN, PAIR 18; COHORT STUDIES; FEMALE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; REPRODUCIBILITY OF RESULTS; VITAMIN A;

EID: 81255209181     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr387     Document Type: Article

References (25)

1. Krinsky, N.I. and Johnson, E.J. (2005) Carotenoid actions and their relation to health and disease. Mol. Aspects Med., 26, 459-516.
2. Sommer, A. (1998) Xerophthalmia and vitamin A status. Prog. Retin. Eye Res., 17, 9-31.
3. Sesso, H.D., Buring, J.E., Norkus, E.P. and Gaziano, J.M. (2005) Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men. Am. J. Clin. Nutr., 81, 990-997.
4. Mondul, A.M., Watters, J.L., Mannisto, S., Weinstein, S.J., Snyder, K., Virtamo, J. and Albanes, D. (2011) Serum retinol and risk of prostate cancer. Am. J. Epidemiol., 173, 813-821.
5. Gueguen, S., Leroy, P., Gueguen, R., Siest, G., Visvikis, S. and Herbeth, B. (2005) Genetic and environmental contributions to serum retinol and alpha-tocopherol concentrations: the Stanislas Family Study. Am. J. Clin. Nutr., 81, 1034-1044.
6. Biesalski, H.K., Frank, J., Beck, S.C., Heinrich, F., Illek, B., Reifen, R., Gollnick, H., Seeliger, M.W., Wissinger, B. and Zrenner, E. (1999) Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein. Am. J. Clin. Nutr., 69, 931-936.
7. Episkopou, V., Maeda, S., Nishiguchi, S., Shimada, K., Gaitanaris, G.A., Gottesman, M.E. and Robertson, E.J. (1993) Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. Proc. Natl Acad. Sci. USA, 90, 2375-2379.
8. Ferrucci, L., Perry, J.R., Matteini, A., Perola, M., Tanaka, T., Silander, K., Rice, N., Melzer, D., Murray, A., Cluett, C. et al. (2009) Common variation in the beta-carotene 15,15′-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am. J. Hum. Genet., 84, 123-133.
9. Ahn, J., Yu, K., Stolzenberg-Solomon, R., Simon, K.C., McCullough, M.L., Gallicchio, L., Jacobs, E.J., Ascherio, A., Helzlsouer, K., Jacobs, K.B. et al. (2010) Genome-wide association study of circulating vitamin D levels. Hum. Mol. Genet., 19, 2739-2745.
10. Major, J.M., Yu, K., Wheeler, W., Zhang, H., Cornelis, M.C., Wright, M.E., Yeager, M., Snyder, K., Weinstein, S.J., Mondul, A. et al. (2011) Genome-wide association study identifies common variants associated with circulating vitamin E levels. Hum. Mol. Genet., 20, 3876-3883.
11. Jacobsson, J.A., Danielsson, P., Svensson, V., Klovins, J., Gyllensten, U., Marcus, C., Schioth, H.B. and Fredriksson, R. (2008) Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. Biochem. Biophys. Res. Commun., 368, 476-482.
12. Heid, I.M., Jackson, A.U., Randall, J.C., Winkler, T.W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M.C., Speliotes, E.K., Magi, R. et al. (2010) Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat. Genet., 42, 949-960.
13. [1994(] The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. The ATBC Cancer Prevention Study Group. Ann. Epidemiol., 4, 1-10.
14. Hayes, R.B., Sigurdson, A., Moore, L., Peters, U., Huang, W.Y., Pinsky, P., Reding, D., Gelmann, E.P., Rothman, N., Pfeiffer, R.M. et al. (2005) Methods for etiologic and early marker investigations in the PLCO trial. Mutat. Res., 592, 147-154.
15. Hunter, D.J., Kraft, P., Jacobs, K.B., Cox, D.G., Yeager, M., Hankinson, S.E., Wacholder, S., Wang, Z., Welch, R., Hutchinson, A. et al. (2007) A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat. Genet., 39, 870-874.
16. Qi, L., Cornelis, M.C., Kraft, P., Stanya, K.J., Linda Kao, W.H., Pankow, J.S., Dupuis, J., Florez, J.C., Fox, C.S., Pare, G. et al. (2010) Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes. Hum. Mol. Genet., 19, 2706-2715.
17. Amundadottir, L., Kraft, P., Stolzenberg-Solomon, R.Z., Fuchs, C.S., Petersen, G.M., Arslan, A.A., Bueno-de-Mesquita, H.B., Gross, M., Helzlsouer, K., Jacobs, E.J. et al. (2009) Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat. Genet., 41, 986-990.
18. Landi, M.T., Chatterjee, N., Yu, K., Goldin, L.R., Goldstein, A.M., Rotunno, M., Mirabello, L., Jacobs, K., Wheeler, W., Yeager, M. et al. (2009) A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. Am. J. Hum. Genet., 85, 679-691.
19. Thomas, G., Jacobs, K.B., Yeager, M., Kraft, P., Wacholder, S., Orr, N., Yu, K., Chatterjee, N., Welch, R., Hutchinson, A. et al. (2008) Multiple loci identified in a genome-wide association study of prostate cancer. Nat. Genet., 40, 310-315.
20. Milne, D.B. and Botnen, J. (1986) Retinol, alpha-tocopherol, lycopene, and alpha- and beta-carotene simultaneously determined in plasma by isocratic liquid chromatography. Clin. Chem., 32, 874-876.
21. Steghens, J.P., van Kappel, A.L., Riboli, E. and Collombel, C. (1997) Simultaneous measurement of seven carotenoids, retinol and alpha-tocopherol in serum by high-performance liquid chromatography. J. Chromatogr. B Biomed. Sci. Appl., 694, 71-81.
22. Sporn, M.B., Roberts, A.B. and Goodman, D.S. (1994) The Retinoids: Biology, Chemistry, and Medicine. New York: Raven Press.
23. El-Sohemy, A., Baylin, A., Kabagambe, E., Ascherio, A., Spiegelman, D. and Campos, H. (2002) Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake. Am. J. Clin. Nutr., 76, 172-179.
24. Olmedilla-Alonso, B., Granado-Lorencio, F. and Blanco-Navarro, I. (2005) Carotenoids, retinol and tocopherols in blood: comparability between serum and plasma (Li-heparin) values. Clin. Biochem., 38, 444-449.
25. Sowell, A.L., Huff, D.L., Yeager, P.R., Caudill, S.P. and Gunter, E.W. (1994) Retinol, alpha-tocopherol, lutein/zeaxanthin, beta-cryptoxanthin, lycopene, alpha-carotene, trans-beta-carotene, and four retinyl esters in serum determined simultaneously by reversed-phase HPLC with multiwavelength detection. Clin. Chem., 40, 411-416.