Comparison of three aspirin formulations in human volunteers

Western Journal of Emergency Medicine

Volumn 12, Issue 4, 2011, Pages 381-385

  Nordt, Sean Patrick ^a   Clark, Richard F ^b   Castillo, Edward M ^b   Guss, David A ^b  

^a LAC USC MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 81255179901     PISSN: 1936900X     EISSN: 19369018     Source Type: Journal    
DOI: 10.5811/westjem.2011.4.2222     Document Type: Article

References (22)

1. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17, 187 cases of suspected acute myocardial infarction: ISIS-2. Lancet. 1988;13:349-360.
2. The American Heart Association in collaboration with the International Liaison Committee on Resuscitation. Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care, part 7: the era of reperfusion, section 1-acute coronary syndromes (acute myocardial infarction). Circulation. 2000;102:I172-I203.
3. Anderson JL, Adams CD, Antman EM, et al. ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction. J Am Coll Cardiol. 2007;50:1-157.
4. Feldman M, Cryer B. Aspirin absorption rates and platelet inhibition times with 325-mg buffered aspirin tablets (chewed or swallowed intact) and with buffered aspirin solution. Am J Cardiol. 1999;84:404-409. (Pubitemid 29398659)
5. Schwertner HA, McGlasson D, Christopher M, et al. Effects of different aspirin formulations on platelet aggregation times and on plasma salicylate concentrations. Thromb Res. 2006;118:529-534. (Pubitemid 44404044)
6. Dabaghi SF, Kamat SG, Payne J, et al. Effects of low-dose aspirin on in vitro platelet aggregation in the early minutes after ingestion in normal subjects. Am J Cardiol. 1994;74:720-723. (Pubitemid 24298929)
7. Maalouf R, Mosley M, Kallail J, et al. A comparison of salicylic acid levels in normal subjects after rectal versus oral dosing. Acad Emerg Med. 2009;16:157-161.
8. Tanen DA, Danish DC, Reardon JM, et al. Comparison of oral aspirin versus topical applied methyl salicylate for platelet inhibition. Ann Pharmacother. 2008;42:1396-1401.
9. McAuley DF. The clinicians ultimate reference. GlobalRPh Web site. Available at: http://www.globalrph.com/labs-drug-levels.htm. Accessed April 18, 2011.
10. Beckman Coulter. SYNCHRON System (s) SALY Chemistry Information Sheet Salicylate. Beckman Coulter, Inc Web site. Available at: http://www. beckmancoulter.com/customersupport/IFU/cis/A18551/AE/EN-SALY.pdf. Accessed December 30, 2009.
11. Needs CJ, Brooks PM. Clinical pharmacokinetics of the salicylates. Clin Pharmacokinet. 1985;10:164-177. (Pubitemid 15104999)
12. Schror K. Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Semin Thromb Hemostas. 1997;23:349-356. (Pubitemid 27360075)
13. Patrono C, Ciabattoni G, Patrignani P, et al. Clinical pharmacology of platelet cyclooxygenase inhibition. Circulation. 1985;72:1177-1184. (Pubitemid 16126796)
14. Lewis HD, Davis JW, Archibold DG, et al. Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina: results of a Veterans Administration Cooperative Study. N Engl J Med. 1983;309:396-403. (Pubitemid 13033964)
15. Barbash IM, Freimark D, Gottlieb S, et al. Outcome of myocardial infarction in patients with aspirin is enhanced by pre-hospital administration. Cardiology. 2009;98:141-147.
16. Abdelnoor M, Landmark K. Infarct size is reduced and the frequency of non-Q-wave myocardial infarction is increased in patients using aspirin at the onset of symptoms. Cardiology. 1999;91:119-126. (Pubitemid 29371552)
17. Eisenberg MJ, Topal EJ. Prehospital administration of aspirin in patients with unstable angina and acute myocardial infarction. Arch Intern Med. 1996;156:1506-1510. (Pubitemid 26244434)
18. Dotevall G, Ekenved G. The absorption of acetylsalicylic acid from the stomach in relation to intragastric pH. Scand J Gastroenterol. 1976;11:801-805. (Pubitemid 8012222)
19. Slattery J, Warlow CP, Shorrock CJ, et al. Risks of gastrointestinal bleeding during secondary prevention of vascular events with aspirin: analysis of gastrointestinal bleeding during the UK-TIA trial. Gut. 1995;37:509-511.
20. Berger JS, Stebbins A, Granger CB, et al. Initial aspirin dose and outcome among ST-elevation myocardial infarction patients treated with fibrinolytic therapy. Circulation. 2008;117:192-199.
21. O'Malley GF. Emergency department management of the salicylatepoisoned patient. Emerg Med Clin North Am. 2007;25:333-346. (Pubitemid 46669881)
22. Flomenbaum NE. Salicylates. In: Flomenbaum NE, Goldfrank LR, Hoffman RS, et al, eds. Goldfrank's Toxicologic Emergencies. 8th ed. New York, NY: McGraw-Hill; 2006:550-564.