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Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 24, 2011, Pages 7268-7272

Biaryl analogues of teriflunomide as potent DHODH inhibitors

(9) Erra, Montse a Moreno, Imma a Sanahuja, Jordi a Andrés, Miriam a Reinoso, Raquel F b Lozoya, Estrella a Pizcueta, Pilar c Godessart, Núria a Castro Palomino, Julio Cesar d

a Almirall Prodesfarma S A (Spain)

b ESTEVE (Spain)

c Centro Nacional de Investigations Oncológicas (Spain)

d PaloBiofarma (Spain)

Author keywords

Autoimmune diseases; DHODH inhibitors; MS; RA; Teriflunomide

Indexed keywords

BIARYL DIHYDROOROTATE DEHYDROGENASE INHIBITOR; DIHYDROOROTATE DEHYDROGENASE; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; TERIFLUNOMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTHRITIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG HALF LIFE; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BINDING SITES; BIPHENYL COMPOUNDS; COMPUTER SIMULATION; CROTONATES; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PROTEIN STRUCTURE, TERTIARY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; TOLUIDINES;

RATTUS;

EID: 81255168477 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.10.052 Document Type: Article

Times cited : (23)

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