New steroidal lactones as 5α-reductase inhibitors and antagonists for the androgen receptor

Journal of Steroid Biochemistry and Molecular Biology

Volumn 127, Issue 3-5, 2011, Pages 367-373

  Garrido, Mariana ^a   Bratoeff, Eugene ^a   Bonilla, Dulce ^b   Soriano, Juan ^c   Heuze, Yvonne ^b   Cabeza, Marisa ^b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b DEPARTAMENTO DE SISTEMAS BIOLÓGICOS   (Mexico)

^c General Hospital of Mexico SS   (Mexico)

Author keywords

5 Reductase inhibitors; Androgen receptor; Human prostate; Pharmacological activity and antiandrogens; Steroidal lactones

Indexed keywords

17A OXA DEXTRO HOMOANDROST 5 EN 17 ONE 3BETA YL 3' OXAPENTANOATE; 17A OXA DEXTRO HOMOANDROST 5 EN 17 ONE 3BETA YL BUTANOATE; 17A OXA DEXTRO HOMOANDROST 5 EN 17 ONE 3BETA YL HEXANOATE; 17A OXA DEXTRO HOMOANDROST 5 EN 17 ONE 3BETA YL PENTANOATE; 17A OXA DEXTRO HOMOANDROST 5 EN 17 ONE 3BETA YL PROPANOATE; 5ALPHA,6BETA DIBROMO 17A OXA DEXTRO HOMOANDROSTANE 3BETA YL 3' OXAPENTANOATE; 5ALPHA,6BETA DIBROMO 17A OXA DEXTRO HOMOANDROSTANE 3BETA YL BUTANOATE; 5ALPHA,6BETA DIBROMO 17A OXA DEXTRO HOMOANDROSTANE 3BETA YL HEXANOATE; 5ALPHA,6BETA DIBROMO 17A OXA DEXTRO HOMOANDROSTANE 3BETA YL PENTANOATE; 5ALPHA,6BETA DIBROMO 17A OXA DEXTRO HOMOANDROSTANE 3BETA YL PROPANOATE; ANDROGEN RECEPTOR; ANDROGEN RECEPTOR ANTAGONIST; FINASTERIDE; LACTONE DERIVATIVE; STEROID; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; GONADECTOMY; HAMSTER; HUMAN; HUMAN TISSUE; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PROSTATE; SEMINAL VESICLE; STRUCTURE ACTIVITY RELATION;

5-ALPHA REDUCTASE INHIBITORS; INHIBITORY CONCENTRATION 50; LACTONES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; RECEPTORS, ANDROGEN; SPECTROPHOTOMETRY, INFRARED; STEROIDS;

ANIMALIA; CRICETINAE; RATTUS;

EID: 81255160846     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2011.07.001     Document Type: Article

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