Does carbetocin for prevention of postpartum haemorrhage at caesarean section provide clinical or financial benefit compared with oxytocin?

Journal of Obstetrics and Gynaecology

Volumn 31, Issue 8, 2011, Pages 732-739

  Higgins, L ^a   Mechery, J ^a   Tomlinson, A J ^a  

^a ROYAL BOLTON HOSPITAL   (United Kingdom)

Author keywords

Caesarean section; Carbetocin; Oxytocin; Postpartum haemorrhage; Service evaluation

Indexed keywords

ANTIEMETIC AGENT; CARBETOCIN; HEMOGLOBIN; OXYTOCIN; UTEROTONIC AGENT;

ADULT; ANALGESIA; BLEEDING; BLOOD TRANSFUSION; CESAREAN SECTION; CONTROLLED STUDY; COST BENEFIT ANALYSIS; FEMALE; HEMODYNAMICS; HOSPITAL COST; HUMAN; HYPOTENSION; INFANT FEEDING; MAJOR CLINICAL STUDY; NAUSEA; POSTNATAL CARE; POSTPARTUM HEMORRHAGE; PRIORITY JOURNAL; REVIEW; TREATMENT OUTCOME; VOMITING;

EID: 81255156876     PISSN: 01443615     EISSN: 13646893     Source Type: Journal    
DOI: 10.3109/01443615.2011.595982     Document Type: Review

References (19)

1. Arulkumaran S, Mavrides E, Penney GC. 2009. Royal College of Obstetricians and Gynaecologists Greentop Guideline No. 52; Prevention and management of postpartum haemorrhage. London: RCOG Press.
2. Atillakos G, Psaroudakis D, Ash J, Buchanan R, Winter C, Donald F et al. 2010. Carbetocin versus oxytocin for the prevention of postpartum haemorrhage following caesarean section: the results of a doubleblind randomised trial. British Journal of Obstetrics and Gynaecology 117:929-936.
3. Barth T, Jost K, Rychlik I. 1975. Milk-ejecting and uterotonic activities of oxytocin in rats. Endocrinologia Experimentalis 9:35-41.
4. Begley CM, Gyte GM, Murphy DJ, Devane D, McDonald SJ, McGuire W. 2010. Active versus expectant management for women in the third stage of labour. Cochrane Database of Systematic Reviews (7):CD007412.
5. Borruto F, Treisser A, Comparetto C. 2009. Utilization of carbetocin for prevention of postpartum haemorrhage after caesarean section: a randomized clinical trial. Archives of Gynecology and Obstetrics 280:707-712.
6. Boucher M, Nimrod CA, Tawagi GF, Meeker TA, Rennicks White RE, Varin J. 2004. Comparison of carbetocin and oxytocin for the prevention of postpartum haemorrhage following vaginal delivery: a double-blind randomized trial. Journal of Obstetrics and Gynaecology, Canada 26:481-488.
7. Chong YS, Su LL, Arulkumaran S. 2004. Current strategies for the prevention of postpartum haemorrhage in the third stage of labour. Current Opinion in Obstetrics and Gynecology 16:143-150. (Pubitemid 38519749)
8. Gulmezoglu AM, Forna F, Villar J, Hofmeyr GJ. 2007. Prostaglan-dins for preventing postpartum haemorrhage. Cochrane Database of Systematic Reviews (3):CD000494.
9. Hofmeyr GJ, Gulmezoglu AM, Novikova N, Linder V, Ferreira S, Piaggio G. 2009. Misoprostol to prevent and treat postpartum haemorrhage: a systematic review and meta-analysis of maternal deaths and dose-related effects. Bulletin of the World Health Organization 87:666-677.
10. Hunter DJ, Schulz P, Wassenaar W. 1992. Effect of carbetocin, a long-acting oxytocin analog on the postpartum uterus. Clinical Pharmacology and Therapeutics 52:60-67.
11. Leduc D, Senikas V, Lalonde AB, Ballerman C, Biringer A, Delaney M et al.; Clinical Practice Obstetrics Committee; Society of Obstetricians and Gynaecologists of Canada. 2009. Active management of the third stage of labour: prevention and treatment of postpartum haemorrhage. Journal of Obstetrics and Gynaecology, Canada 31:980-993.
12. Leung SW, Ng PS, Wong WY, Cheung TH. 2006. A randomised trial of carbetocin versus syntometrine in the management of the third stage of labour. British Journal of Obstetrics and Gynaecology 113:1459-1464. (Pubitemid 44736693)
13. NICE. 2004. Caesarean section CG13. London: National Institute for Health and Clinical Excellence.
14. Peters NC, Duvekot JJ. 2009. Carbetocin for the prevention of postpartum haemorrhage: a systematic review. Obstetrical and Gynecological Survey 64:129-135.
15. Prendiville WJ, Elbourne D, McDonald S. 2000. Active versus expectant management in the third stage of labour. Cochrane Database of Systematic Reviews (3):CD000007.
16. Su L-L, Chong Y-S, Samuel M. 2007. Oxytocin agonists for preventing postpartum haemorrhage. Cochrane Database of Systematic Reviews (3):CD005457.
17. Su L-L, Rauff M, Chan YH, Mohamad Suphan N, Lau TP, Biswas A et al. 2009. Carbetocin versus syntometrine for the third stage of labour following vaginal delivery-a double blind randomised controlled trial. British Journal of Obstetrics and Gynaecology 116:1461-1466.
18. Thomas J, Paranjothy S; Royal College of Obstetricians and Gynaecologists Clinical Effectiveness Support Unit. 2001. The National Sentinel Caesarean Section Audit Report. London: RCOG Press.
19. Wedisinghe L, Macleod M, Murphy DJ. 2008. Use of oxytocin to prevent haemorrhage at caesarean section-a survey of practice in the United Kingdom. European Journal of Obstetrics, Gynecology, and Reproductive Biology 137:27-30. (Pubitemid 351625434)