Application of quantitative 19F and 1H NMR for reaction monitoring and in situ yield determinations for an early stage pharmaceutical candidate

Analytical Chemistry

Volumn 83, Issue 22, 2011, Pages 8766-8771

  Do, Nga M ^a   Olivier, Mark A ^a   Salisbury, John J ^a   Wager, Carrie B ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; ANALYTES; ANALYTICAL CHALLENGE; ANALYTICAL TECHNIQUES; CHROMATOGRAPHIC TECHNIQUES; IN-SITU; NMR SPECTROMETRY; NON-DESTRUCTIVE TECHNIQUE; PROCESS DEVELOPMENT; QUANTITATIVE INFORMATION; REACTION MONITORING; REFERENCE MATERIAL; REFERENCE STANDARD; SEPARATION TECHNIQUES; THERMAL INSTABILITIES; UV ABSORPTION;

SYNTHESIS (CHEMICAL);

IONIC LIQUIDS;

DRUG; FLUORINE; PROTON;

ARTICLE; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

FLUORINE; MAGNETIC RESONANCE SPECTROSCOPY; PHARMACEUTICAL PREPARATIONS; PROTONS;

EID: 81255151149     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac202287y     Document Type: Article

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