Hippocampal α7 nicotinic acetylcholine receptor levels in patients with schizophrenia, bipolar disorder, or major depressive disorder

Bipolar Disorders

Volumn 13, Issue 7-8, 2011, Pages 701-707

  Thomsen, Morten S ^a   Weyn, Annelies ^a   Mikkelsen, Jens D ^a  

^a Mental Health Services CPH   (Denmark)

Author keywords

Alpha 7 nicotinic receptor; Bipolar disorder; Bungarotoxin; Major depressive disorder; Schizophrenia; Temporal lobe

Indexed keywords

BUNGAROTOXIN RECEPTOR; IODINE 125;

ADULT; ARTICLE; AUTOPSY; AUTORADIOGRAPHY; BIPOLAR DISORDER; BRAIN LEVEL; CONTROLLED STUDY; DENTATE GYRUS; FEMALE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HUMAN; HUMAN TISSUE; LIGAND BINDING; MAJOR DEPRESSION; MALE; PERIRHINAL CORTEX; PRIORITY JOURNAL; SCHIZOPHRENIA;

ADULT; ANALYSIS OF VARIANCE; AUTORADIOGRAPHY; BIPOLAR DISORDER; BUNGAROTOXINS; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; IODINE ISOTOPES; MALE; MIDDLE AGED; PROTEIN BINDING; RECEPTORS, NICOTINIC; SCHIZOPHRENIA;

EID: 81255138921     PISSN: 13985647     EISSN: 13995618     Source Type: Journal    
DOI: 10.1111/j.1399-5618.2011.00961.x     Document Type: Article

References (38)

1. Clarke PB, Schwartz RD, Paul SM, Pert CB, Pert A. Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin. J Neurosci 1985; 5: 1307-1315.
2. Breese CR, Adams C, Logel J et al. Comparison of the regional expression of nicotinic acetylcholine receptor alpha7 mRNA and [125I]-alpha-bungarotoxin binding in human postmortem brain. J Comp Neurol 1997; 387: 385-398.
3. Seguela P, Wadiche J, Dineley-Miller K, Dani JA, Patrick JW. Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium. J Neurosci 1993; 13: 596-604.
4. Thomsen MS, Hansen HH, Timmerman DB, Mikkelsen JD. Cognitive improvement by activation of alpha7 nicotinic acetylcholine receptors: from animal models to human pathophysiology. Curr Pharm Des 2010; 16: 323-343.
5. Stefansson H, Rujescu D, Cichon S et al. Large recurrent microdeletions associated with schizophrenia. Nature 2008; 455: 232-236.
6. ISC. The International Schizophrenia Consortium. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 2008; 455:237-241.
7. Leonard S, Gault J, Hopkins J et al. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch Gen Psychiatry 2002; 59: 1085-1096.
8. Zammit S, Spurlock G, Williams H et al. Genotype effects of CHRNA7, CNR1 and COMT in schizophrenia: interactions with tobacco and cannabis use. Br J Psychiatry 2007; 191: 402-407.
9. Iwata Y, Nakajima M, Yamada K et al. Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia. Neurosci Res 2007; 57: 194-202.
10. Sanders AR, Duan J, Levinson DF et al. No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics. Am J Psychiatry 2008; 165: 497-506.
11. Breese CR, Lee MJ, Adams CE et al. Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia. Neuropsychopharmacology 2000; 23: 351-364.
12. Freedman R, Hall M, Adler LE, Leonard S. Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol Psychiatry 1995; 38: 22-33.
13. Marutle A, Zhang X, Court J et al. Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia. J Chem Neuroanat 2001; 22: 115-126.
14. Mathew SV, Law AJ, Lipska BK et al. Alpha7 nicotinic acetylcholine receptor mRNA expression and binding in postmortem human brain are associated with genetic variation in neuregulin 1. Hum Mol Genet 2007; 16: 2921-2932.
15. Sweatt JD. Hippocampal function in cognition. Psychopharmacology 2004; 174: 99-110.
16. Ancin I, Barabash A, Vazquez-Alvarez B et al. Evidence for association of the non-duplicated region of CHRNA7 gene with bipolar disorder but not with Schizophrenia. Psychiatr Genet 2010; 20: 289-297.
17. Hong CJ, Lai IC, Liou LL, Tsai SJ. Association study of the human partially duplicated alpha7 nicotinic acetylcholine receptor genetic variant with bipolar disorder. Neurosci Lett 2004; 355: 69-72.
18. Joo EJ, Lee KY, Kim HS, Kim SH, Ahn YM, Kim YS. Genetic Association Study of the Alpha 7 Nicotinic Receptor (CHRNA7) with the Development of Schizophrenia and Bipolar Disorder in Korean Population. Psychiatry Investig 2010; 7: 196-201.
19. Shi J, Hattori E, Zou H et al. No evidence for association between 19 cholinergic genes and bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 2007; 144B: 715-723.
20. Lai IC, Hong CJ, Tsai SJ. Association study of nicotinic-receptor variants and major depressive disorder. J Affect Disord 2001; 66: 79-82.
21. Lopez-Leon S, Janssens AC, Gonzalez-Zuloeta Ladd AM et al. Meta-analyses of genetic studies on major depressive disorder. Mol Psychiatry 2008; 13: 772-785.
22. Mineur YS, Picciotto MR. Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis. Trends Pharmacol Sci 2010; 31: 580-586.
23. Torrey EF, Webster M, Knable M, Johnston N, Yolken RH. The stanley foundation brain collection and neuropathology consortium. Schizophr Res 2000; 44: 151-155.
24. De Luca V, Likhodi O, Van Tol HH, Kennedy JL, Wong AH. Regulation of alpha7-nicotinic receptor subunit and alpha7-like gene expression in the prefrontal cortex of patients with bipolar disorder and schizophrenia. Acta Psychiatr Scand 2006; 114: 211-215.
25. Severance EG, Yolken RH. Lack of RIC-3 congruence with beta2 subunit-containing nicotinic acetylcholine receptors in bipolar disorder. Neuroscience 2007; 148: 454-460.
26. de Lucas-Cerrillo AM, Maldifassi MC, Arnalich F et al. Function of partially duplicated human alpha77 nicotinic receptor subunit CHRFAM7A gene: potential implications for the cholinergic anti-inflammatory response. J Biol Chem 2011; 286: 594-606.
27. Villiger Y, Szanto I, Jaconi S et al. Expression of an alpha7 duplicate nicotinic acetylcholine receptor-related protein in human leukocytes. J Neuroimmunol 2002; 126: 86-98.
28. Millar NS. RIC-3: a nicotinic acetylcholine receptor chaperone. Br J Pharmacol 2008; 153(Suppl. 1): S177-S183.
29. Lansdell SJ, Gee VJ, Harkness PC et al. RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells. Mol Pharmacol 2005; 68: 1431-1438.
30. Wang Y, Yao Y, Tang XQ, Wang ZZ. Mouse RIC-3, an endoplasmic reticulum chaperone, promotes assembly of the alpha7 acetylcholine receptor through a cytoplasmic coiled-coil domain. J Neurosci 2009; 29: 12625-12635.
31. Ancin I, Cabranes JA, Santos JL et al. CHRNA7 haplotypes are associated with impaired attention in euthymic bipolar disorder. J Affect Disord 2011; 133: 340-345.
32. Shytle RD, Silver AA, Sheehan KH, Sheehan DV, Sanberg PR. Neuronal nicotinic receptor inhibition for treating mood disorders: preliminary controlled evidence with mecamylamine. Depress Anxiety 2002; 16: 89-92.
33. Burt T, Sachs GS, Demopulos C. Donepezil in treatment-resistant bipolar disorder. Biol Psychiatry 1999; 45: 959-964.
34. Eden Evins A, Demopulos C, Nierenberg A, Culhane MA, Eisner L, Sachs G. A double-blind, placebo-controlled trial of adjunctive donepezil in treatment-resistant mania. Bipolar Disord 2006; 8: 75-80.
35. Mexal S, Berger R, Logel J, Ross RG, Freedman R, Leonard S. Differential regulation of alpha7 nicotinic receptor gene (CHRNA7) expression in schizophrenic smokers. J Mol Neurosci 2010; 40: 185-195.
36. Gentry CL, Lukas RJ. Regulation of nicotinic acetylcholine receptor numbers and function by chronic nicotine exposure. Current drug targets 2002; 1: 359-385.
37. Zhang X, Liu C, Miao H, Gong ZH, Nordberg A. Postnatal changes of nicotinic acetylcholine receptor alpha 2, alpha 3, alpha 4, alpha 7 and beta 2 subunits genes expression in rat brain. Int J Dev Neurosci 1998; 16: 507-518.
38. Li JG, Lehr M, Liu-Chen LY, Woodruff-Pak DS. Nicotinic acetylcholine receptors and modulation of learning in 4- and 27-month-old rabbits. Neuropsychopharmacology 2008; 33: 2820-2830.