Lacosamide, new antiepileptic with broad perspectives;Lacosamida, nuevo antiepiléptico con amplias perspectivas

Neurologia

Volumn 26, Issue 9, 2011, Pages 568-569

  Gutierrez alvarez A M ^a   Sagarra Mur, D ^a   Jimenez Corral C ^a  

^a HOSPITAL SANTA BÁRBARA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HARKOSERIDE;

EPILEPSY; LETTER;

ACETAMIDES; ANTICONVULSANTS; EPILEPSY; FEMALE; HUMANS; MIDDLE AGED; MIGRAINE DISORDERS;

EID: 81255137987     PISSN: 02134853     EISSN: 15781968     Source Type: Journal    
DOI: 10.1016/j.nrl.2011.03.002     Document Type: Letter

References (5)

1. Stöhr T., Kupferberg H.J., Stables J.P., Choi D., Harris R.H., Kohn H., et al. Lacosamide, a novel anticonvulsivant drug, shows efficacy with a wide safety margin in rodent models for epilepsy. Epileplsy Res 2007, 74:147-154.
2. Halasz P., Kälviainen R., Marzurkiewicz-Beldzinska M., Rosenow F., Doty P., Herbert D., et al. Adjunctive lacosamide for partial-onset seizures: efficacy and safety results from a randomized controlled trial. Epilepsia 2009, 50:443-453. SP755 Study Group.
3. Marín-Muñoz H., Gil-Nagel A., Thomas D., Scharfenecker U., Nickel B., Doty P., et al. La lacosamida tiene un bajo potencial de interacciones farmacológicas [abstract P19]. VII Reunión Anual de la Asociación Madrileña de Neurología. Rev Neurol 2010, 50:504.
4. Errington A.C., Stöhr T., Heers C., Lees G. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Neurofarmacology 2006, 50:1016-1029.
5. Löscher W., Hönack D., Rundfeldt C. Antiepileptogenic Effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. JPET 1998, 284:474-479.