The hematopoietic cell transplantation-specific comorbidity index fails to predict outcomes in high-risk AML patients undergoing allogeneic transplantation-investigation of potential limitations of the index

Biology of Blood and Marrow Transplantation

Volumn 17, Issue 12, 2011, Pages 1822-1832

  Birninger, Nicole ^a   Bornhäuser, Martin ^a   Schaich, Markus ^a   Ehninger, Gerhard ^a   Schetelig, Johannes ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

Author keywords

Acute myeloid leukemia; Allogeneic stem cell transplantation; Hematopoietic cell transplantation specific comorbidity index; HSCT CI

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CHILD; COMORBIDITY; FEMALE; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; OUTCOMES RESEARCH; PATIENT SELECTION; PREDICTION; PROGNOSIS; RETROSPECTIVE STUDY; SCORING SYSTEM;

ADOLESCENT; ADULT; AGED; CHILD; COHORT STUDIES; COMORBIDITY; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; PROGNOSIS; RETROSPECTIVE STUDIES; RISK FACTORS; SURVIVAL ANALYSIS; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 81255136076     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2011.06.009     Document Type: Article

References (31)

1. Mathe G., Amiel J.L., Schwarzenberg L., et al. Successful allogenic bone marrow transplantation in man: chimerism, induced specific tolerance and possible anti-leukemic effects. Blood 1965, 25:179-196.
2. Sorror M.L., Maris M.B., Storb R., et al. Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT. Blood 2005, 106:2912-2919.
3. Sorror M.L., Sandmaier B.M., Storer B.E., et al. Comorbidity and disease status based risk stratification of outcomes among patients with acute myeloid leukemia or myelodysplasia receiving allogeneic hematopoietic cell transplantation. J Clin Oncol 2007, 25:4246-4254.
4. Sorror M.L., Giralt S., Sandmaier B.M., et al. Hematopoietic cell transplantation specific comorbidity index as an outcome predictor for patients with acute myeloid leukemia in first remission: combined FHCRC and MDACC experiences. Blood 2007, 110:4606-4613.
5. Farina L., Bruno B., Patriarca F., et al. The hematopoietic cell transplantation comorbidity index (HCT-CI) predicts clinical outcomes in lymphoma and myeloma patients after reduced-intensity or non-myeloablative allogeneic stem cell transplantation. Leukemia 2009, 23:1131-1138.
6. Majhail N.S., Brunstein C.G., McAvoy S., et al. Does the hematopoietic cell transplantation specific comorbidity index predict transplant outcomes? A validation study in a large cohort of umbilical cord blood and matched related donor transplants. Biol Blood Marrow Transplant 2008, 14:985-992.
7. Wildes T.M., Augustin K.M., Sempek D., et al. Comorbidities, not age, impact outcomes in autologous stem cell transplant for relapsed non-Hodgkin lymphoma. Biol Blood Marrow Transplant 2008, 14:840-846.
8. Labonte L., Iqbal T., Zaidi M.A., et al. Utility of comorbidity assessment in predicting transplantation-related toxicity following autologous hematopoietic stem cell transplantation for multiple myeloma. Biol Blood Marrow Transplant 2008, 14:1039-1044.
9. Castagna L., Furst S., Marchetti N., et al. Retrospective analysis of common scoring systems and outcome in patients older than 60 years treated with reduced-intensity conditioning regimen and alloSCT. Bone Marrow Transplant 2010.
10. Guilfoyle R., Demers A., Bredeson C., et al. Performance status, but not the hematopoietic cell transplantation comorbidity index (HCT-CI), predicts mortality at a Canadian transplant center. Bone Marrow Transplant 2009, 43:133-139.
11. Terwey T.H., Hemmati P.G., Martus P., et al. A modified EBMT risk score and the hematopoietic cell transplantation-specific comorbidity index for pre-transplant risk assessment in adult acute lymphoblastic leukemia. Haematologica 2010, 95:810-818.
12. Platzbecker U., Thiede C., Freiberg-Richter J., et al. Early allogeneic blood stem cell transplantation after modified conditioning therapy during marrow aplasia: stable remission in high-risk acute myeloid leukemia. Bone Marrow Transplant 2001, 27:543-546.
13. Sorror M., Storer B., Sandmaier B.M., et al. Hematopoietic cell transplantation-comorbidity index and Karnofsky performance status are independent predictors of morbidity and mortality after allogeneic nonmyeloablative hematopoietic cell transplantation. Cancer 2008, 112:1992-2001.
14. Weisdorf D., Spellman S., Haagenson M., et al. Classification of HLA-matching for retrospective analysis of unrelated donor transplantation: revised definitions to predict survival. Biol Blood Marrow Transplant 2008, 14:748-758.
15. Atkinson K., Horowitz M.M., Gale R.P., Lee M.B., Rimm A.A., Bortin M.M. Consensus among bone marrow transplanters for diagnosis, grading and treatment of chronic graft-versus-host disease. Committee of the International Bone Marrow Transplant Registry. Bone Marrow Transplant 1989, 4:247-254.
16. Przepiorka D., Weisdorf D., Martin P., et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant 1995, 15:825-828.
17. Shulman HM, Sullivan KM, Weiden PL, et al. Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients. Am J Med. 980;69:204-217.
18. Chien J.W., Madtes D.K., Clark J.G. Pulmonary function testing prior to hematopoietic stem cell transplantation. Bone Marrow Transplant 2005, 35:429-435.
19. Gooley T.A., Leisenring W., Crowley J., Storer B.E. Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med 1999, 18:695-706.
20. Fine J., Gray R. A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 1999, 94:496-509.
21. Ihaka R., Gentleman R. R: a language for data analysis and graphics. Comput Graph Stat 1996, 5:299-314.
22. Slovak M.L., Kopecky K.J., Cassileth P.A., et al. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood 2000, 96:4075-4083.
23. Bernheim S.M., Ross J.S., Krumholz H.M., Bradley E.H. Influence of patients' socioeconomic status on clinical management decisions: a qualitative study. Ann Fam Med 2008, 6:53-59.
24. Majhail N.S., Omondi N.A., Denzen E., Murphy E.A., Rizzo J.D. Access to hematopoietic cell transplantation in the United States. Biol Blood Marrow Transplant 2010, 16:1070-1075.
25. Singh J.P., Evans J.C., Levy D., et al. Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study). Am J Cardiol 1999, 83:897-902.
26. Barba P., Pinana J.L., Martino R., et al. Comparison of two pretransplant predictive models and a flexible HCT-CI using different cut off points to determine low-, intermediate-, and high-risk groups: the flexible HCT-CI is the best predictor of NRM and OS in a population of patients undergoing allo-RIC. Biol Blood Marrow Transplant 2010, 16:413-420.
27. Defor T.E., Majhail N.S., Weisdorf D.J., et al. A modified comorbidity index for hematopoietic cell transplantation. Bone Marrow Transplant 2010, 45:933-938.
28. Altman D.G., Royston P. What do we mean by validating a prognostic model?. Stat Med 2000, 19:453-473.
29. Kataoka K., Nannya Y., Ueda K., Kumano K., Takahashi T., Kurokawa M. Differential prognostic impact of pretransplant comorbidity on transplant outcomes by disease status and time from transplant: a single Japanese transplant centre study. Bone Marrow Transplant 2010, 45:513-520.
30. Patel P., Sweiss K., Nimmagadda S., Gao W., Rondelli D. Comorbidity index does not predict outcome in allogeneic myeloablative transplants conditioned with fludarabine/i.v. busulfan (FluBu4). Bone Marrow Transplant 2010.
31. Smith A.R., Majhail N.S., Macmillan M.L., et al. Hematopoietic cell transplantation comorbidity index predicts transplant outcomes in pediatric patients. Blood 2011.