Immune reconstitution in recipients of photodepleted HLA-identical sibling donor stem cell transplantations: T cell subset frequencies predict outcome

Biology of Blood and Marrow Transplantation

Volumn 17, Issue 12, 2011, Pages 1846-1854

  McIver, Zachariah A ^a   Melenhorst, Jan J ^a   Grim, Andrew ^a   Naguib, Nicholas ^a   Weber, Gerrit ^a   Fellowes, Vicki ^b   Khuu, Hahn ^b   Stroncek, David S ^b   Leitman, Susan F ^b   Battiwalla, Minoo ^a   Barrett, A John ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

CD4 central memory; GVHD; Photodepletion; TH9402; Transplantation

Indexed keywords

ARTICLE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CHRONIC GRAFT VERSUS HOST DISEASE; CLINICAL ARTICLE; DONOR LYMPHOCYTE INFUSION; EFFECTOR CELL; EX VIVO STUDY; GRAFT RECIPIENT; HLA MATCHING; HUMAN; HUMAN CELL; IMMUNOCOMPETENCE; IRRADIATION; LEUKEMIA RELAPSE; MEMORY T LYMPHOCYTE; PHOTOSENSITIZATION; PREDICTION; SIBLING; STEM CELL TRANSPLANTATION; SURVIVAL; T LYMPHOCYTE SUBPOPULATION; TREATMENT OUTCOME;

CD4-CD8 RATIO; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HLA ANTIGENS; HUMANS; LYMPHOCYTE DEPLETION; MALE; PHOTOSENSITIZING AGENTS; RHODAMINES; SIBLINGS; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; TISSUE DONORS; TREATMENT OUTCOME;

EID: 81255135916     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2011.05.017     Document Type: Article

References (23)

1. Dazzi F., Fozza C. Disease relapse after haematopoietic stem cell transplantation: risk factors and treatment. Best Pract Res Clin Haematol 2007, 20:311-327.
2. Fujiwara H., Sconocchia G., Melenhorst J., et al. Tissue-restricted T cell alloresponses across HLA barriers: selection and identification of leukemia-restricted CTL in HLA-mismatched stimulator-responder pairs. Bone Marrow Transplant 2003, 32:371-378.
3. Michalek J., Collins R.H., Durrani H.P., et al. Definitive separation of graft-versus-leukemia- and graft-versus-host-specific CD4+ T cells by virtue of their receptor beta loci sequences. Proc Natl Acad Sci U S A 2003, 100:1180-1184.
4. Mavroudis D.A., Dermime S., Molldrem J., et al. Specific depletion of alloreactive T cells in HLA-identical siblings: a method for separating graft-versus-host and graft-versus-leukaemia reactions. Br J Haematol 1998, 101:565-570.
5. Mielke S., Solomon S.R., Barrett A.J. Selective depletion strategies in allogeneic stem cell transplantation. Cytotherapy 2005, 7:109-115.
6. Chen B.J., Cui X., Liu C., Chao N.J. Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process. Blood 2002, 99:3083-3088.
7. Guimond M., Balassy A., Barrette M., Brochu S., Perreault C., Roy D.C. P-glycoprotein targeting: a unique strategy to selectively eliminate immunoreactive T cells. Blood 2002, 100:375-382.
8. Mielke S., Nunes R., Rezvani K., et al. A clinical-scale selective allodepletion approach for the treatment of HLA-mismatched and matched donor-recipient pairs using expanded T lymphocytes as antigen-presenting cells and a TH9402-based photodepletion technique. Blood 2008, 111:4392-4402.
9. Mielke S., McIver Z., Shenoy A., et al. Selectively T cell depleted allografts from HLA-matched sibling donors followed by low-dose post transplant immunosuppression to improve transplant outcome in patients with hematological malignancies. Biol Blood Marrow Transplant 2011, 17:1855-1861.
10. Melenhorst J.J., Scheinberg P., Chattopadhyay P.K., et al. Detection of low avidity CD8(+) T cell populations with coreceptor-enhanced peptide-major histocompatibility complex class I tetramers. J Immunol Methods 2008, 338:31-39.
11. Melenhorst J.J., Scheinberg P., Chattopadhyay P.K., et al. High avidity myeloid leukemia-associated antigen-specific CD8+ T cells preferentially reside in the bone marrow. Blood 2009, 113:2238-2244.
12. Scheinberg P., Melenhorst J.J., Brenchley J.M., et al. The transfer of adaptive immunity to CMV during hematopoietic stem cell transplantation is dependent on the specificity and phenotype of CMV-specific T cells in the donor. Blood 2009, 114:5071-5080.
13. Huet S., Marie J.P., Gualde N., Robert J. Reference method for detection of Pgp mediated multidrug resistance in human hematological malignancies: a method validated by the laboratories of the French Drug Resistance Network. Cytometry 1998, 34:248-256.
14. Brenchley J.M., Douek D.C. Flow cytometric analysis of human antigen-specific T-cell proliferation. Methods Cell Biol 2004, 75:481-496.
15. Melenhorst J.J., Solomon S.R., Shenoy A., et al. Robust expansion of viral antigen-specific CD4+ and CD8+ T cells for adoptive T cell therapy using gene-modified activated T cells as antigen presenting cells. J Immunother 2006, 29:436-443. Discussion 365-366.
16. Sullivan K.M., Shulman H.M., Storb R., et al. Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression. Blood 1981, 57:267-276.
17. Solomon S.R., Mielke S., Savani B.N., et al. Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation. Blood 2005, 106:1123-1129.
18. Ludescher C., Pall G., Irschick E.U., Gastl G. Differential activity of P-glycoprotein in normal blood lymphocyte subsets. Br J Haematol 1998, 101:722-727.
19. Berger C., Jensen M.C., Lansdorp P.M., Gough M., Elliott C., Riddell S.R. Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Invest 2008, 118:294-305.
20. Matsuoka K., Kim H.T., McDonough S., et al. Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation. J Clin Invest 2010, 120:1479-1493.
21. Sakaguchi S., Miyara M., Costantino C.M., Hafler D.A. FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol 2010, 10:490-500.
22. Roy D.C., Lachance S., Kiss T., et al. Haploidentical stem cell transplantation: high doses of alloreactive-T cell depleted donor lymphocytes administered post-transplant decreases infections and improve survival without causing severe GVHD. Blood 2009, 112:212.
23. Scheinberg P., Price D.A., Ambrozak D.R., Barrett A.J., Douek D.C. Alloreactive T cell clonotype recruitment in a mixed lymphocyte reaction: implications for graft engineering. Exp Hematol 2006, 34:788-795.