The in vitro metabolism of sphingosine-1-phosphate: Identification; Inhibition and pharmacological implications

European Journal of Pharmacology

Volumn 672, Issue 1-3, 2011, Pages 56-61

  Bradley, Michelle E ^a,b   McGuinness, Neil ^a,c   Williams, Gareth ^a   Charlton, Steven J ^a   Dowling, Mark R ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b 1MedImmune   (United Kingdom)

^c ASTRAZENECA   (United Kingdom)

Author keywords

S1P metabolism; S1P 2 receptor; Sodium orthovanadate; Sphingosine; Sphingosine 1 phosphate

Indexed keywords

GUANOSINE 5' O (3 THIOTRIPHOSPHATE); SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; UNCLASSIFIED DRUG; VANADATE SODIUM;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; IN VITRO STUDY; INCUBATION TIME; LIPID METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; ENZYME INHIBITORS; HUMANS; KINETICS; LYSOPHOSPHOLIPIDS; PHOSPHORIC MONOESTER HYDROLASES; RECEPTORS, LYSOSPHINGOLIPID; SPHINGOSINE; VANADATES;

EID: 81255135901     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.09.178     Document Type: Article

References (22)

1. M.M. Bradford A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
2. L. Chun, Lynch K.R. Hla, S. Spiegel, and W.H. Moolenaar International Union of Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature Pharmacol. Rev. 62 4 2010 579 587
3. O. Cuvillier Sphingosine in apoptosis signaling Biochim. Biophys. Acta 1585 2002 153 162 (Pubitemid 36092080)
4. A. Huwiler, and J. Pfeilschifter New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets Biochem. Pharmacol. 75 2008 1893 1900
5. D.S. Im Pharmacology tools for lysophospholipid G-protein coupled receptors: development of agonists and antagonists for LPA and S1P receptors Acta Pharmacol. Sin. 31 9 2010 1213 1222
6. A. Kihara, T. Sano, S. Iwaki, and Y. Igarashi Transmembrane topology of sphingoid long-chain base-1-phosphate phosphatase, Lcb3p Genes Cells 8 2003 525 535 (Pubitemid 36748456)
7. H. Le Stunff, C. Peterson, H. Liu, S. Milstien, and S. Spiegel Sphingosine-1-phosphate and lipid phosphohydrolases Biochim. Biophys. Acta 1582 2002 8 17 (Pubitemid 34634106)
8. H. Le Stunff, S. Milstien, and S. Spiegel Generation and metabolism of bioactive sphingosine-1-phosphate J. Cell. Biochem. 92 2004 882 899 (Pubitemid 44264239)
9. P. Leff, and I.G. Dougal Further concerns over Cheng-Prusoff analysis Trends Pharmacol. Sci. 14 1993 110 112 (Pubitemid 23113114)
10. S.M. Mandala, R. Thornton, I. Galve-Roperh, S. Poulton, C. Peterson, A. Olivera, J. Bergstrom, M.B. Kurtz, and S. Spiegel Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death Proc. Natl. Acad. Sci. U.S.A. 97 2000 7859 7864 (Pubitemid 30460738)
11. D. Marsolais, and H. Rosen Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules Nat. Rev. Drug Discov. 8 2009 297 307
12. C. Ogawa, A. Kihara, M. Gokoh, and Y. Igarashi Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2 J. Biol. Chem. 78 2003 1268 1272 (Pubitemid 36790810)
13. U. Peest, S.C. Sensken, P. Andréani, P. Hänel, P.P. Van Veldhoven, and M.H. Gräler S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake J. Cell. Biochem. 104 2008 756 772 (Pubitemid 351830827)
14. D.K. Perry Serine palmitoyltransferase: role in apoptotic de novo ceramide synthesis and other stress responses Biochim. Biophys. Acta 1585 2002 146 152 (Pubitemid 36092079)
15. B.J. Pettus, C.E. Chalfant, and Y.A. Hannun Ceramide in apoptosis: an overview and current perspectives Biochim. Biophys. Acta 1585 2002 114 125 (Pubitemid 36092075)
16. R. Rivera, and J. Chun Biological effects of lysophospholipids Rev. Physiol. Biochem. Pharmacol. 160 2008 25 46
17. L.E. Seargeant, and R.A. Stinson Inhibition of human alkaline phosphatases by vanadate Biochem. J. 181 1979 247 250 (Pubitemid 9236535)
18. S. Speigel, and S. Milstien Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways Biochem. Soc. Trans. 31 2003 1216 1219 (Review) (Pubitemid 38030942)
19. G.M. Strub, M. Maceyka, S. Milstien, and S. Spiegel Extracellular and intracellular actions of sphingosine-1-phosphate Adv. Exp. Med. Biol. 688 2010 141 155
20. K. Takabe, S.W. Paugh, S. Milstien, and S. Spiegel "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets Pharmacol. Rev. 60 2008 181 195 (Pubitemid 351962008)
21. N. Young, and J.R. Van Brocklyn Signal transduction of sphingosine-1-phosphate G protein coupled receptors Scientific World Journal 6 2006 946 966 (Pubitemid 44252720)
22. J. Zhou, and J.D. Saba Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast Biochem. Biophys. Res. Commun. 242 1998 502 507 (Pubitemid 28412556)