Diffuse expression of PAX2 and PAX8 in the cystic epithelium of mixed epithelial stromal tumor, angiomyolipoma with epithelial cysts, and primary renal synovial sarcoma: Evidence supporting renal tubular differentiation

American Journal of Surgical Pathology

Volumn 35, Issue 9, 2011, Pages 1264-1273

  Karafin, Matthew ^a   Parwani, Anil V ^a   Netto, Georges J ^a,b   Illei, Peter B ^a   Epstein, Jonathan I ^a   Ladanyi, Marc ^c   Argani, Pedram ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

AMLEC; MEST; PAX2; PAX8; synovial sarcoma

Indexed keywords

PAIRED BOX TRANSCRIPTION FACTOR; PAX2 PROTEIN, HUMAN; PAX8 PROTEIN, HUMAN; TRANSCRIPTION FACTOR PAX2;

ADOLESCENT; ADULT; AGED; ANGIOMYOLIPOMA; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CHEMISTRY; CLINICAL TRIAL; CONNECTIVE TISSUE TUMOR; EPITHELIUM CELL; FEMALE; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; KIDNEY TUBULE; KIDNEY TUMOR; MALE; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; NEOPLASM; PATHOLOGY; STROMA CELL; TISSUE MICROARRAY; UNITED STATES;

ADOLESCENT; ADULT; AGED; ANGIOMYOLIPOMA; CELL DIFFERENTIATION; CELL LINEAGE; EPITHELIAL CELLS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KIDNEY NEOPLASMS; KIDNEY TUBULES; MALE; MIDDLE AGED; NEOPLASMS, CYSTIC, MUCINOUS, AND SEROUS; PAIRED BOX TRANSCRIPTION FACTORS; PAX2 TRANSCRIPTION FACTOR; SARCOMA, SYNOVIAL; STROMAL CELLS; TISSUE ARRAY ANALYSIS; UNITED STATES;

EID: 81155162625     PISSN: 01475185     EISSN: 15320979     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31822539a1     Document Type: Article

References (23)

1. Adsay NV, Eble JN, Srigley JR, et al. Mixed epithelial stromal tumor of the kidney. Am J Surg Pathol. 2000;24:958-970. (Pubitemid 30430483)
2. Argani P, Ladanyi M. Recent advances in pediatric renal neoplasia. Adv Anat Pathol. 2003;10:243-260.
3. Argani P, Faria PA, Epstein JI, et al. Primary renal synovial sarcoma: Molecular and morphologic delineation of an entity previously included among embryonal sarcomas of the kidney. Am J Surg Pathol. 2000;24:1087-1096. (Pubitemid 30612830)
4. Armah HB, Yin M, Rao UN, et al. Angiomyolipoma with epithelial cysts (AMLEC): a rare but distinct variant of angiomyolipoma. Diagn Pathol. 2007;2:11.
5. Beiko DT, Nickel JC, Boag AH, et al. Benign mixed epithelial stroma tumor of the kidney of possible mullerian origin. J Urol. 2001;166:1381-1382. (Pubitemid 32862183)
6. Davis CJ, Barton JH, Sesterhenn IA. Cystic angiomyolipoma of the kidney: a clinicopathologic description of 11 cases. Mod Pathol. 2006;19:669-674.
7. Delahunt B, Beckwith JB, Eble JN, et al. Cystic embryonal sarcoma of kidney: a case report. Cancer. 1998;82:2427-2433. (Pubitemid 28283450)
8. Fine SW, Reuter VE, Epstein JI, et al. Angiomyolipoma with epithelial cysts (AMLEC): a distinct cystic variant of angiomyolipoma. Am J Surg Pathol. 2006;30:593-599. (Pubitemid 44265011)
9. Fukunaga M, Mistuda A, Shibuya K, et al. Retroperitoneal lymphangioleiomyomatosis associated with endosalpingiosis. APMIS. 2007;115:1460-1465.
10. Gokden N, Gokden M, Phan DC, et al. The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic Mimicsb: an immunohistochemical study with comparison to renal cell carcinoma marker. Am J Surg Pathol. 2008;32:1462-1467.
11. Gupta R, Balzer B, Picken M, et al. Diagnostic implications of transcription factor Pax 2 protein and transmembrane enzyme complex carbonic anhydrase IX immunoreactivity in adult renal epithelial neoplasms. Am J Surg Pathol. 2009;33:241-247.
12. Kawai A, Woodruff J, Healey JH, et al. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med. 1998;338:153-160. (Pubitemid 28041862)
13. Kum JB, Wang M, Grignon DJ, et al. Molecular assessment of clonality in mixed epithelial and stromal tumors of the kidney: evidence for a single cell of origin with capacity for epithelial and stromal differentiation. Mod Pathol. 2011;24(S1):204A-205A.
14. Matsui K, Travis WD, Gonzalez R, et al. Association of lymphangioleiomyomatosis (LAM) with endosalpingiosis in the retroperitoneal lymph nodes: report of two cases. Int J Surg Pathol. 2001;9:155-162. (Pubitemid 32619737)
15. Memeo L, Jhang J, Assaad AM, et al. Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma. Am J Clin Pathol. 2007;127:225-229. (Pubitemid 46797179)
16. Ozcan A, Zhai J, Hamilton C, et al. PAX-2 in the diagnosis of primary renal tumors: immunohistochemical comparison with renal cell carcinoma marker antigen and kidney-specific cadherin. Am J Clin Pathol. 2009;131:393-404.
17. Pawade J, Soosay JN, Delprado W, et al. Cystic hamartoma of the renal pelvis. Am J Surg Pathol. 1993;17:1169-1175. (Pubitemid 23313791)
18. Parikh P, Chan TY, Epstein JI, et al. Incidental stromalpredominant mixed epithelial-stromal tumors of the kidney. Arch Pathol Lab Med. 2005;129:910-914.
19. Portier BY, Hansel DE, Zhou M, et al. Mixed epithelial and stromal tumor of the kidney. J Urol. 2009;181:1879-1880.
20. Tickoo SK, Gopalan A, Tu JJ, et al. Estrogen and progesteronereceptor- positive stroma as a non-tumorous proliferation in kidneys: a possible metaplastic response to obstruction. Mod Pathol. 2008;21:60-65.
21. Tong G-X, Chiriboga L, Hamele-Bena D, et al. Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Mü llerian system origin? Mod Pathol. 2007;20:856-863. (Pubitemid 47077268)
22. Tong GX, Yu WM, Beaubier NT, et al. Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study. Mod Pathol. 2009;22:1218-1227.
23. Turbiner J, Amin MB, Humphrey PA, et al. Cystic Nephroma and mixed epithelial and stromal tumor of kidney: a detailed clinicopathologic analysis of 34 cases and proposal for renal epithelial and stromal tumor (REST) as a unifying term. AmJ Surg Pathol. 2007;31:489-500. (Pubitemid 46569032)