Prognostic markers in patients with cirrhosis and portal hypertension who have not bled

Disease Markers

Volumn 31, Issue 3, 2011, Pages 147-154

  Poca, Maria ^a   Puente, Angela ^a   Graupera, Isabel ^a   Villanueva, Càndid ^a,b  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Compensated cirrhosis; hepatic venous pressure gradient; HVPG monitoring; Prognostic markers

Indexed keywords

ARTICLE; ASCITES; BLEEDING; BLOOD EXAMINATION; COMPENSATED LIVER CIRRHOSIS; DECOMPENSATED LIVER CIRRHOSIS; DIAGNOSTIC ACCURACY; DISEASE COURSE; DISEASE SEVERITY; ELASTOGRAPHY; ESOPHAGUS VARICES; HEMODYNAMICS; HEPATIC VENOUS PRESSURE GRADIENT; HUMAN; LIVER CIRRHOSIS; LIVER EXAMINATION; MORTALITY; PATIENT MONITORING; PORTAL HYPERTENSION; PRIORITY JOURNAL; PROGNOSIS; PROPHYLAXIS; RISK FACTOR; TRANSIENT ELASTOGRAPHY;

EID: 81155154240     PISSN: 02780240     EISSN: 18758630     Source Type: Journal    
DOI: 10.3233/DMA-2011-0837     Document Type: Article

References (68)

1. G. D'Amico, G. Garcia-Tsao and L. Pagliaro, Natural history and prognostic indicators of survival in cirrhosis: Asystematic review of 118 studies, J Hepatol 44 (2006), 217-231. (Pubitemid 41772537)
2. G. Garcia-Tsao, S. Friedman, J. Iredale and M. Pinzani, Now there are many (stages) where before there was one: In search of pathophysiological classification of cirrhosis, Hepatology 51 (2010), 1445-1449.
3. G. D'Amico, A. Morabito, L. Pagliaro and E. Marubini, Survival and prognostic indicators in compensated and decompensated cirrhosis, Dig Dis Sci 31 (1986), 468-475. (Pubitemid 16085568)
4. G. Garcia-Tsao and J. Bosch, Management of varices and variceal hemorrhage in cirrhosis, N Engl J Med 362 (2010), 823-832.
5. G. D'Amico, J.C. Garcia-Pagan, A. Luca and J. Bosch, Hepatic vein pressure gradient reduction and prevention of variceal bleeding in cirrhosis: A systematic review, Gastroenterology 131 (2006), 1611-1624. (Pubitemid 44708947)
6. R.J. Groszmann, G. Garcia-Tsao, J. Bosch, N.D. Grace, A.K. Burroughs, R. Planas, A. Escorsell, J.C. Garcia-Pagan, D. Patch, D.S. Matloff, H. Gao and R. Makuch, for the Portal Hypertension Collaborative Group. Beta-blockers to prevent gastroesophageal varices in patients with cirrhosis, N Engl J Med 353 (2005), 2254-2261. (Pubitemid 41697288)
7. C. Ripoll, R. Groszmann, G. Garcia-Tsao, N. Grace, A. Burroughs, R. Planas, A. Escorsell, J.C. Garcia-Pagan, R. Makuch, D. Patch, D.S. Matloff and J. Bosch, Hepatic venous pressure gradient predicts clinical descompensation in patients with compensated cirrhosis, Gastroenterology 133 (2007), 481-488. (Pubitemid 47187350)
8. R.J. Groszmann, J. Bosch, N.D. Grace et al., Hemodynamic events in a prospective randomized trial of propranolol versus placebo in the prevention of a first variceal hemorrhage, Gastroenterology 99 (1990), 1401-1407. (Pubitemid 20381877)
9. G. Garcia-Tsao, R.J. Groszmann, J. Bosch, N.D. Grace, A.K. Burroughs, R. Planas et al., Baseline hepatic venous pressure gradient (HVPG) and VHC infection predict the development of clinically significant portal hypertension (CSPH), Hepatology 48 (2008), 625A.
10. G. Garcia-Tsao, R.J. Groszmann, R.L. Fisher, H.O. Conn, C.E. Atterbury and M. Glickman, Portal pressure, presence of gastroesophageal varices and variceal bleeding, Hepatology 5 (1985), 419-424. (Pubitemid 15065948)
11. G. Garcia-Tsao, J. Bosch and R.J. Groszmann, Portal hypertension and variceal bleeding- Unresolved issues. Summary of an american association for the study of liver diseases and european association for the study of liver single-topic conference, Hepatology 47 (2008), 1764-1772. (Pubitemid 351702758)
12. F. Feu, J.C. García-Pagán, J. Bosch, A. Luca, J. Terés and A. Escorsell, Relation between portal pressure response to pharmacotherapy and risk of recurrent varcieal haemorrhage in patients with cirrosis, Lancet 346 (1995), 1056-1059.
13. C. Villanueva, J. Balanzó, M.T. Novella, G. Soriano, S. Sainz, X. Torras et al., Nadolol plus isosorbidemononitrate compared with sclerotherapy for the prevention of variceal rebleeding, N Engl J Med 334 (1996), 1624-1629. (Pubitemid 26192521)
14. U. Thalheimer, J. Bosch and A.K. Burroughs, How to prevent varices from bleeding: Shades of grey - The case for nonselective β-blockers, Gastroenterology 133 (2007), 2029-2036. (Pubitemid 350180826)
15. J.G. Abraldes, I. Tarantino, J. Turnes, J.C. Garcia-Pagan, J. Rodés and J. Bosch, Hemodynamic response to pharmacological treatment of portal hypertension and long-term prognosis of cirrhosis, Hepatology 37 (2003), 902-908. (Pubitemid 36397403)
16. C. Villanueva, J.M. López-Balaguer, C. Aracil, L. Kolle, B. González, J. Miñana, G. Soriano, C. Guarner and J. Balanzó, Maintenance of hemodynamic response to treatment for portal hypertension and influence on complications of cirrhosis, J Hepatol 40 (2004), 757-765. (Pubitemid 38507355)
17. C. Villanueva, J. Miñana, J. Ortix, A. Gallego, G. Soriano, X. Torras et al., Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding, N Engl J Med 345 (2001), 647-655.
18. U. Thalheimer, M. Mela, D. Patch and A.K. Burroughs, Targeting portal pressure measurements: A critical reappraisal, Hepatology 39 (2004), 286-290. (Pubitemid 38222166)
19. C. Villanueva, C. Aracil, A. Colomo and J. Balanzo, Nonselective -β lockers and hepatic venous pressure gradient monitoring: what lies behind nonresponse, Gastroenterology 134 (2008), 1626-1627. (Pubitemid 351615401)
20. J. Turnes, J.C. Garcia-Pagan, J.G. Abraldes, M. Hernandez- Guerra, A. Dell'Era and J. Bosch, Pharmacological Reduction of Portal Pressure and Long-Term Risk of First Variceal Bleeding in Patients with Cirrhosis, Am J Gastroenterol 101 (2006), 506-512. (Pubitemid 43340926)
21. C. Merkel, M. Bolognesi, D. Sacerdoti, G. Bombonato, B. Bellini, R. Bighin and A. Gatta, The hemodynamic response to medical treatment of portal hypertension as a predictor of clinical effectiveness in the primary prophylaxis of variceal bleeding in cirrhosis, Hepatology 32 (2000), 930-934.
22. C. Villanueva, C. Aracil, A. Colomo, V. Hernández-Gea, J.M. López-Balaguer, C. Alvarez-Urturi, X. Torras, J. Balanzó and C. Guarner, Acute hemodynamic response to beta-blockers and prediction of long-term outcome in primary prophylaxis of variceal bleeding, Gastroenterology 137 (2009), 119-128.
23. V. Hernandez-Gea, A. Colomo, C. Aracil, M. Concepcion, M. Poca, X. Torras, H. Santos, C. Guarner and C. Villanueva, Relationship between changes in portal pressure and development of ascites in cirrhotic patients with severe portal hypertension, Hepatology 50 (2009), 313A.
24. V. LaMura, J.G. Abraldes, J.C. Raffa, O. Retto, A. Berzigotti, J.C. García-Pagán and J. Bosch, Porgnostic value of acute hemodynamic response to i.v. propranolol in patients with cirrhosis and portal hypertension, J Hepatol 51 (2009), 279-287.
25. A. Sangiovanni, G.M. Prati, P. Fasani, G. Ronchi, R. Romeo, M. Manini, E. Del Ninno, A. Morabito and M. Colombo, The natural history of compensated cirrhosis due to hepatitis C virus: A 17-year cohort study of 214 patients, Hepatology (2006), 1303-1310. (Pubitemid 43980109)
26. A.J. Sanyal, C. Banas, C. Sargeant, V.A. Luketic, R.K. Sterling, R.T. Stravitz, M.L. Shiffman, D. Heuman, A. Coterrell, R.A. Fisher, M.J. Contos and A.S. Mills, Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C, Hepatology 43 (2006), 682-689.
27. D. Thabut, F. Imbert-Bismut, D. Cazals-Hatem, D. Messous, M.Muntenaus, D.C. Valla et al., Relationship between the FibroTest and portal hypertension in patients with liver disease, Aliment Pharmacol Ther 26 (2007), 359-368. (Pubitemid 47063142)
28. T. Poynard, R. Morra, P. Halfon, L. Castera, V. Ratziu, F. Imbert-Bismut et al., Meta-analyses of FibroTest diagnostic value in chronic liver disease, BMC Gastroenterol 7 (2007), 40.
29. D. Thabut, R.Moreau andD. Lebrec, NoninvasiveAssessment of Portal Hypertension in Patients With Cirrhosis, Hepatology 53 (2011), 683-694.
30. M. Kondo, S.J. Miszputen, M.M. Leite-Mor and E.R. Parise, The predictive value of serum laminin for the risk of variceal bleeding related to portal pressure levels, Hepatogastroenterology 42 (1995), 542-545.
31. J. Kropf, A.M. Gressner and W. Tittor, Logistic-regression model for assessing portal hypertension by measuring hyaluronic acid (hyaluronan) and laminin in serum, Clin Chem 37 (1991), 30-35. (Pubitemid 21892597)
32. L. Castera, X. Forms and A. Alberti, Non-invasive evaluation of liver fibrosis using transient elastography, J Hepatol 48 (2008), 835-847.
33. J.A. Talwalkar, D.M. Kurtz, S.J. Schoenleber, C.P. West and V.M. Montori, Ultrasound-based transient elastography for the detection of hepatic fibrosis: systematic review and metaanalysis, Clin Gastroenterol Hepatol 5 (2007), 1214-1220. (Pubitemid 47488974)
34. M. Friedrich-Rust, M.F. Ong, S.J. Martens, C. Sarrazin, J. Bojunga, S. Zeuzen et al., Performance of transient elastography for the staging of liver fibrosis: a meta-analysis, Gastroenterology 134 (2008), 960-974.
35. L. Castera, J. Foucher, P.H. Bernard, F. Carvalho, D. Allaix, W. Merrouche et al., Pitfalls of liver stiffness measurement: a 5-year prospective study of 13,369 examinations, Hepatology 51 (2010), 828-835.
36. F. Vizzutti, U. Arena, R.G. Romanelli, L. Rega, M. Foschi, S. Colagrande et al., Liver stiffness measurement predicts severe portal hypertension in patients with HCV-related cirrhosis, Hepatology 45 (2007), 1290-1297. (Pubitemid 46775793)
37. C. Bureau, S. Metivier, J.M. Peron, J. Selves, M.A. Robic, P.A. Gourraud et al., Transient elastography accurately predicts presence of significant portal hypertension in patients with chronic liver disease, Aliment Pharmacol Ther 27 (2008), 1261-1268. (Pubitemid 351697282)
38. M. Lemoine, S. Katsahian, M. Ziol, P. Nahon, N. Ganne- Carrie, F. Kazemi et al., Liver stiffness measurement as predictive tool of clinically significant portal hypertension in patients with compensated hepatitis C virus or alcohol-related cirrhosis, Aliment Pharmacol Ther 28 (2008), 1102-1110.
39. L. Castéra, B. Le Bail, F. Roudot-Thoraval, P.H. Bernard, J. Foucher, W. Merrouche et al., Early detection in routine clinical practice of cirrhosis and oesophageal varices in chronic hepatitis C: comparison of transient elastography (FibroScan) with standard laboratory tests and non-invasive scores, J Hepatol 50 (2009), 59-68.
40. M.Yin, J.A. Talwalkar, K.J. Glaser, A.Manduca, R.C. Grimm, P.J. Rossman et al., Assessment of hepatic fibrosis with magnetic resonance elastography, Clin Gastroenterol Hepatol 5 (2007), 1207-1213.
41. L. Huwart, C. Sempoux, E. Vicaut, N. Salameh, L. Annet, E. Danse et al., Magnetic resonance elastography for the noninvasive staging of liver fibrosis, Gastroenterology 135 (2008), 32-40. (Pubitemid 351899024)
42. G. D'Amico, L. Pasta, S. Madonia, G. Tarantino, A. Mancuso, G. Malizia et al., The incidence of esophageal varices in cirrhosis, Gastroenterology 120 (2001), A2.
43. G. D'Amico, Natural history of compensated cirrhosis and varices, in: Complications of Cirrhosis: Pathogenesis, Consequences and Therapy, T.D. Boyer and R.J. Groszmann, eds, American Association for the Study of Liver Diseases, 2001, pp. 118-123.
44. The North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study, N Engl J Med 319 (1988), 983-989.
45. M.Merli, G.Nicolini, S.Angeloni, V. Rinaldi, A.De Santis, C. Merkel et al., Incidence and natural history of small esophageal varices in cirrhotic patients, J Hepatol 38 (2003), 266-272. (Pubitemid 36286538)
46. A.J. Sanyal, R.J. Fontana, A.M. DiBisceglie, J.E. Everhart, M.C.Doherty, G.T. Everson et al., The prevalence and risk factors associated with esophageal varices in subjects with hepatitis C and advanced fibrosis, Gastrointest Endosc 64 (2006), 855-864. (Pubitemid 44829826)
47. G. Garcia-Tsao, A.J. Sanyal, N.D. Grace, W. Carey and the Practice Guidelines Committee of the American Association for the Study of Liver Diseases, the Practice Parameters Committee of the American College of Gastroenterology. Prevention and Management of Gastroesophageal Varices and Variceal Hemorrhage in Cirrhosis, Hepatology 46 (2007), 922-938. (Pubitemid 47436138)
48. R. De Franchis, Revising consensus in portal hypertension: Report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension, J Hepatol 53 (2010), 762-768.
49. G. Eisen, R. Eliakim, A. Zaman, J. Schwartz, D. Faigel, E. Rondonotti et al., The accuracy of PillCam ESO capsule endoscopy versus conventional upper endoscopy for the diagnosis of oesophageal varices: a prospective three-center pilot study, Endoscopy 38 (2006), 31-35. (Pubitemid 43092701)
50. M.G. Lapalus, J. Dumortier, F. Fumex, S. Roman, M. Lot, B. Prost et al., Oesophageal capsule endoscopy versus oesophagogastroduodenoscopy for evaluating portal hypertension. A prospective comparative study of performance and tolerance, Endoscopy 38 (2006), 36-41. (Pubitemid 43092702)
51. L.R. Pena, T. Cox, A.G. Koch and A. Bosch, Study comparing oesophageal capsule endoscopy versus EGD in the detection of varices, Dig Liver Dis 40 (2008), 216-223.
52. R. de Franchis, G.M. Eisen, L. Laine, I. Fernandez-Urien, J.M. Herrerias, R.D. Brown et al., Esophageal capsule endoscopy for screening and surveillance of esophageal varices in patients with portal hypertension, Hepatology 47 (2008), 1595-1603. (Pubitemid 351715209)
53. M.G. Lapalus, E. Ben Soussan, M. Gaudric, J.C. Saurin, P.N. D'Halluin, O. Favre et al., Esophageal capsule endoscopy vs. EGD for the evaluation of portal hypertension: a French prospective multicenter comparative study, Am J Gastroenterol 104 (2009), 1112-1118.
54. A. Zaman, R. Hapke, K. Flora, H.R. Rosen and K. Benner, Factors predicting the presence of esophageal or gastric varices in patients with advanced liver disease, Am J Gastroenterol 94 (1999), 3292-3296.
55. F. Schepis, C. Camma, D. Niceforo, A.Magnano, S. Pallio, M. Cinquegrani et al., Which patients with cirrhosis should undergo endoscopic screening for esophageal varices detection? Hepatology 33 (2001), 333-338. (Pubitemid 32119022)
56. R. Madhotra, H.E. Mulcahy, I. Willner and A. Reuben, Prediction of esophageal varices in patients with cirrhosis, J Clin Gastroenterol 34 (2002), 81-85. (Pubitemid 34038486)
57. A.A. Qamar, N.D. Grace, R.J. Groszmann, G. Garcia-Tsao, J. Bosch, A.K. Burroughs et al., Platelet count is not a predictor of the presence or development of gastroesophageal varices in cirrhosis, Hepatology 47 (2008), 153-159. (Pubitemid 351171052)
58. G. Sebastiani, D. Tempesta, G. Fattovich, L. Castera, P. Halfon, M. Bourliere, F. Noventa, P. Angeli, A. Saggioro and A. Alberti, Prediction of oesophageal varices in hepatic cirrhosis by simple serum non-invasive markers: Results of a multicenter, large-scale study, J Hepatol 53 (2010), 630-638.
59. E. Giannini, F. Botta, P. Borro, D. Risso, P. Romagnoli, A. Fasoli et al., Platelet count/spleen diameter ratio: proposal and validation of a non-invasive parameter to predict the presence of oesophageal varices in patients with liver cirrhosis, Gut 52 (2003), 1200-1205. (Pubitemid 36877436)
60. E.G. Giannini, A. Zaman, A. Kreil, A. Floreani, P. Dulbecco, E. Testa et al., Platelet count/spleen diameter ratio for the noninvasive diagnosis of esophageal varices: results of a multicenter, prospective, validation study, Am J Gastroenterol 101 (2006), 2511-2519. (Pubitemid 44665246)
61. D. Thabut, J.B. Trabut, J. Massard, M. Rudler, M. Muntenau, D. Messous et al., Non-invasive diagnosis of large oesophageal varices with FibroTest in patients with cirrhosis: a preliminary retrospective study, Liver Int 26 (2006), 271-278. (Pubitemid 43349315)
62. M. Zoli, C. Merkel, D. Magalotti, C. Gueli, M. Grimaldi, A. Gatta et al., Natural history of cirrhotic patients with small esophageal varices: a prospective study, Am J Gastroenterol 95 (2000), 503-508. (Pubitemid 30106184)
63. C. Merkel, R. Marin, P. Angeli, P. Zanella, M. Felder, E. Bernardinello et al., A placebo-controlled clinical trial of nadolol in the prophylaxis of growth of small esophageal varices in cirrhosis, Gastroenterology 127 (2004), 476-484. (Pubitemid 39091896)
64. G. D'Amico, L. Pagliaro and J. Bosch, Pharmacological treatment of portal hypertension: an evidence-based approach, Semin Liver Dis 19 (1999), 475-505. (Pubitemid 30032646)
65. R. Wiest and R.J. Groszmann, The paradox of nitric oxide in cirrhosis and portal hypertension: Too much, not enough, Heptology 35 (2002), 478-491. (Pubitemid 34110432)
66. Y. Iwakiri and R.J. Groszmann, The hyperdynamic circulation of chronic liver diseases: from the patient to the molecule, Hepatology 43(Suppl 1) (2006), S121-S131.
67. J. Bosch, A. Berzigotti, J.C. Garcia-Pagan and J.G. Abraldes, The management ofn portal hypertension: Rational basis, available treatments and future options, J Hepatol 48 (2008), S68-S92.
68. A.A. Qamar, R.J. Groszmann, N.D. Grace, G. Garcia-Tsao, A.K. Burroughs and J. Bosch, Lack of effect of non-selective beta-blockers on the hepatic venous pressure gradient (HVPG) in patients with mild portal hypertension: a tale of two studies, Hepatology 52(Suppl 1) (2010), 1020A.