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Volumn 46, Issue 6, 2011, Pages 228-240

Multiple sclerosis: A paradigm change with oral agents?

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; ALEMTUZUMAB; BETA INTERFERON; BETA1A INTERFERON; CLADRIBINE; CORTICOSTEROID; CYCLOPHOSPHAMIDE; DACLIZUMAB; ESTRADIOL; FINGOLIMOD; FUMARIC ACID DIMETHYL ESTER; GADOLINIUM; GESTAGEN; GLATIRAMER; INTERFERON BETA SERINE; LAQUINIMOD; LIVER ENZYME; MITOXANTRONE; NATALIZUMAB; NEUTRALIZING ANTIBODY; NEW DRUG; PLACEBO; RITUXIMAB; TERIFLUNOMIDE;

EID: 81155154200     PISSN: 1082801X     EISSN: 19381166     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (3)

References (47)
  • 1
    • 81155154917 scopus 로고    scopus 로고
    • National Multiple Sclerosis Society, Accessed January 31
    • National Multiple Sclerosis Society. About MS: Who Gets MS? http://nationalmssociety.org/about-multiple-sclerosis/what-we-know-about-ms/who-gets-ms/index.aspx. Accessed January 31, 2011.
    • (2011) About MS: Who Gets MS?
  • 2
    • 77956236570 scopus 로고    scopus 로고
    • Multiple sclerosis: A practical overview for clinicians
    • Rejdak K, Jackson S, Giovannoni G. Multiple sclerosis: a practical overview for clinicians. Br Med Bull. 2010;95:79-104.
    • (2010) Br Med Bull , vol.95 , pp. 79-104
    • Rejdak, K.1    Jackson, S.2    Giovannoni, G.3
  • 3
    • 33745675511 scopus 로고    scopus 로고
    • Costs and quality of life in multiple sclerosis: A cross-sectional study in the United States
    • Kobelt G, Berg J, Atherly D, Hadjimichael O. Costs and quality of life in multiple sclerosis: a cross-sectional study in the United States. Neurology. 2006;66:1696-1702.
    • (2006) Neurology , vol.66 , pp. 1696-1702
    • Kobelt, G.1    Berg, J.2    Atherly, D.3    Hadjimichael, O.4
  • 4
    • 33244466021 scopus 로고    scopus 로고
    • Natural history of multiple sclerosis: A unifying concept
    • Confavreux C, Vukusic S. Natural history of multiple sclerosis: a unifying concept. Brain. 2006;129:606-616.
    • (2006) Brain , vol.129 , pp. 606-616
    • Confavreux, C.1    Vukusic, S.2
  • 5
    • 0021035886 scopus 로고
    • Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS)
    • Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983;33:1444-1452.
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 6
    • 73149094510 scopus 로고    scopus 로고
    • Recent developments in multiple sclerosis therapeutics
    • Spain RI, Cameron MH, Bourdette D. Recent developments in multiple sclerosis therapeutics. BMC Med. 2009;7:74.
    • (2009) BMC Med , vol.7 , pp. 74
    • Spain, R.I.1    Cameron, M.H.2    Bourdette, D.3
  • 7
    • 81155143750 scopus 로고    scopus 로고
    • National Clinical Advisory Board of the Na, tional Multiple Sclerosis Society, Accessed January 31
    • National Clinical Advisory Board of the National Multiple Sclerosis Society. Disease Management Consensus Statement. http://www.nationalmssociety.org/download.aspx?id=8. Accessed January 31, 2011.
    • (2011) Disease Management Consensus Statement
  • 8
    • 81155137069 scopus 로고    scopus 로고
    • Avonex [package insert]. Cambridge, MA: Biogen Idec, Inc
    • Avonex [package insert]. Cambridge, MA: Biogen Idec, Inc.; 2008.
    • (2008)
  • 9
    • 81155143759 scopus 로고    scopus 로고
    • Rebif [package insert]. Rockland, ME: EMD Serono, Inc.; New York, NY: Pflzer, Inc
    • Rebif [package insert]. Rockland, ME: EMD Serono, Inc.; New York, NY: Pflzer, Inc.; 2009.
    • (2009)
  • 10
    • 81155154919 scopus 로고    scopus 로고
    • Betaseron [package insert]. Montville, NJ: Bayer HealthCare Pharmaceuticals
    • Betaseron [package insert]. Montville, NJ: Bayer HealthCare Pharmaceuticals; 2010.
    • (2010)
  • 11
    • 81155143757 scopus 로고    scopus 로고
    • Copaxone [package insert]. Kansas City, MO: Teva Neuroscience, Inc
    • Copaxone [package insert]. Kansas City, MO: Teva Neuroscience, Inc.; 2009.
    • (2009)
  • 12
    • 81155143758 scopus 로고    scopus 로고
    • Gilenya [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation
    • Gilenya [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2010.
    • (2010)
  • 13
    • 81155154920 scopus 로고    scopus 로고
    • Ampyra [package insert]. Hawthorne, NY: Acorda Therapeuticals, Inc
    • Ampyra [package insert]. Hawthorne, NY: Acorda Therapeuticals, Inc.; 2010.
    • (2010)
  • 14
    • 81155143754 scopus 로고    scopus 로고
    • Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines, AHRQ, National Guideline Clearinghouse, NGC-3144., Accessed August 10
    • Disease modifying therapies in multiple sclerosis: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the MS Council for Clinical Practice Guidelines. AHRQ, National Guideline Clearinghouse, NGC-3144. http://www.guideline.gov/content.aspx?id=4099&search=multiple+sclerosis. Accessed August 10, 2010.
    • (2010)
  • 16
    • 0008678962 scopus 로고    scopus 로고
    • And the Multiple Sclerosis Collaborative Research Group (MSCRG). Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis
    • Jacobs LD, Cookfair DL, Rudick RA, et al. And the Multiple Sclerosis Collaborative Research Group (MSCRG). Intramuscular interferon beta-1a for disease progression in relapsing multiple sclerosis. Ann Neurol. 1996;39:285-294.
    • (1996) Ann Neurol , vol.39 , pp. 285-294
    • Jacobs, L.D.1    Cookfair, D.L.2    Rudick, R.A.3
  • 17
    • 0345601517 scopus 로고    scopus 로고
    • Randomised double-blind placebo-controlled study of interferon ß-1a in relapsing/remitting multiple sclerosis
    • PRISMS Study Group
    • PRISMS Study Group. Randomised double-blind placebo-controlled study of interferon ß-1a in relapsing/remitting multiple sclerosis. Lancet. 1998;352:1498-1504.
    • (1998) Lancet , vol.352 , pp. 1498-1504
  • 18
    • 79551666754 scopus 로고    scopus 로고
    • Risks vs beneflts of glatiramer acetate: A changing perspective as new therapies emerge for multiple sclerosis
    • Johnson KP. Risks vs beneflts of glatiramer acetate: a changing perspective as new therapies emerge for multiple sclerosis. Ther Clin Risk Manag. 2010;6:153-172.
    • (2010) Ther Clin Risk Manag , vol.6 , pp. 153-172
    • Johnson, K.P.1
  • 19
    • 0029082566 scopus 로고
    • And the Copolymer 1 Multiple Sclerosis Study Group. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind, placebo-controlled trial
    • Johnson KP, Brooks BR, Cohen JA, et al. And the Copolymer 1 Multiple Sclerosis Study Group. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind, placebo-controlled trial. Neurology. 1995;45:1268-1276.
    • (1995) Neurology , vol.45 , pp. 1268-1276
    • Johnson, K.P.1    Brooks, B.R.2    Cohen, J.A.3
  • 20
    • 77956160606 scopus 로고    scopus 로고
    • Treatment options for multiple sclerosis: Current and emerging therapies
    • Gawronski KM, Rainka MM, Patel MJ, Gengo FM. Treatment options for multiple sclerosis: current and emerging therapies. Pharmacotherapy. 2010;30:916-927.
    • (2010) Pharmaco-Therapy , vol.30 , pp. 916-927
    • Gawronski, K.M.1    Rainka, M.M.2    Patel, M.J.3    Gengo, F.M.4
  • 21
    • 0037180479 scopus 로고    scopus 로고
    • For the EVIDENCE Study Group and the University of British Columbia MS/MRI Research Group. Randomized, comparative study of interferon ß-1a treatment regimens in MS: The EVIDENCE Trial
    • Panitch H, Goodin DS, Francis G, et al. For the EVIDENCE Study Group and the University of British Columbia MS/MRI Research Group. Randomized, comparative study of interferon ß-1a treatment regimens in MS: the EVIDENCE Trial. Neurology. 2002;59:1496-1506.
    • (2002) Neurology , vol.59 , pp. 1496-1506
    • Panitch, H.1    Goodin, D.S.2    Francis, G.3
  • 22
    • 0037181634 scopus 로고    scopus 로고
    • And the Independent Comparison of Interferon (IN-COMIN) Trial Study Group. Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: Results of a 2-year prospective randomised multicentre study (INCOMIN)
    • Durelli L, Verdun E, Barbero P, et al. And the Independent Comparison of Interferon (IN-COMIN) Trial Study Group. Every-other-day interferon beta-1b versus once-weekly interferon beta-1a for multiple sclerosis: results of a 2-year prospective randomised multicentre study (INCOMIN). Lancet. 2002;359:1453-1460.
    • (2002) Lancet , vol.359 , pp. 1453-1460
    • Durelli, L.1    Verdun, E.2    Barbero, P.3
  • 23
    • 69949098534 scopus 로고    scopus 로고
    • For the BEYOND Study Group. 250 μg or 500 μg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: A prospective, randomised, multicentre study
    • O'Connor P, Filippi M, Arnason B, et al. For the BEYOND Study Group. 250 μg or 500 μg interferon beta-1b versus 20 mg glatiramer acetate in relapsing-remitting multiple sclerosis: a prospective, randomised, multicentre study. Lancet Neurol. 2009;8:889-897.
    • (2009) Lancet Neurol , vol.8 , pp. 889-897
    • O'Connor, P.1    Filippi, M.2    Arnason, B.3
  • 24
    • 51449101000 scopus 로고    scopus 로고
    • On behalf of the REGARD study group. Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): A multicentre, randomised, parallel, open-label trial
    • Mikol DD, Barkhof F, Chang P, et al. On behalf of the REGARD study group. Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): a multicentre, randomised, parallel, open-label trial. Lancet Neurol. 2008;7:903-914.
    • (2008) Lancet Neurol , vol.7 , pp. 903-914
    • Mikol, D.D.1    Barkhof, F.2    Chang, P.3
  • 25
    • 67649476210 scopus 로고    scopus 로고
    • Efflcacy of treatment of MS with IFNß-1b or glatiramer acetate by monthly brain MRI in the BECOME study
    • Cadavid D, Wolansky LJ, Skurnick J, et al. Efflcacy of treatment of MS with IFNß-1b or glatiramer acetate by monthly brain MRI in the BECOME study. Neurology. 2009;72:1976-1983.
    • (2009) Neurology , vol.72 , pp. 1976-1983
    • Cadavid, D.1    Wolansky, L.J.2    Skurnick, J.3
  • 26
    • 0037153729 scopus 로고    scopus 로고
    • And the Mitoxantrone in Multiple Sclerosis Study Group (MIMS). Mitoxantrone in progressive multiple sclerosis: A placebo-controlled, double-blind, randomised, multicentre trial
    • Hartung H, Gonsette R, König N, et al. And the Mitoxantrone in Multiple Sclerosis Study Group (MIMS). Mitoxantrone in progressive multiple sclerosis: a placebo-controlled, double-blind, randomised, multicentre trial. Lancet. 2002;360:2018-2025.
    • (2002) Lancet , vol.360 , pp. 2018-2025
    • Hartung, H.1    Gonsette, R.2    König, N.3
  • 27
    • 33644584352 scopus 로고    scopus 로고
    • For the AFFIRM Investigators. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    • Polman CH, O'Connor PW, Havrdova E, et al. For the AFFIRM Investigators. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med. 2006;354:899-910.
    • (2006) N Engl J Med , vol.354 , pp. 899-910
    • Polman, C.H.1    O'Connor, P.W.2    Havrdova, E.3
  • 28
    • 33644608613 scopus 로고    scopus 로고
    • For the SENTINEL Investigators. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
    • Rudick RA, Stuart WH, Calabresi PA, et al. For the SENTINEL Investigators. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N Engl J Med. 2006;354:911-923.
    • (2006) N Engl J Med , vol.354 , pp. 911-923
    • Rudick, R.A.1    Stuart, W.H.2    Calabresi, P.A.3
  • 29
    • 36549047503 scopus 로고    scopus 로고
    • Brain sphingosine-1-phosphate receptors: Implication for FTY720 in the treatment of multiple sclerosis
    • Dev KK, Mullershausen F, Mattes H, et al. Brain sphingosine-1-phosphate receptors: implication for FTY720 in the treatment of multiple sclerosis. Pharmacol Ther. 2008;117:77-93.
    • (2008) Pharmacol Ther , vol.117 , pp. 77-93
    • Dev, K.K.1    Mullershausen, F.2    Mattes, H.3
  • 30
    • 76149093586 scopus 로고    scopus 로고
    • For the FREEDOMS Study Group. A placebo-controlled trial of oral flngolimod in relapsing multiple sclerosis
    • Kappos L, Radue EW, O'Connor P, et al.For the FREEDOMS Study Group. A placebo-controlled trial of oral flngolimod in relapsing multiple sclerosis. N Engl J Med. 2010;362:387-401.
    • (2010) N Engl J Med , vol.362 , pp. 387-401
    • Kappos, L.1    Radue, E.W.2    O'Connor, P.3
  • 31
    • 76149140914 scopus 로고    scopus 로고
    • For the TRANSFORMS Study Group. Oral flngolimod or intramuscular interferon for relapsing multiple sclerosis
    • Cohen JA, Barkhof F, Comi G, et al. For the TRANSFORMS Study Group. Oral flngolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010;362:402-415.
    • (2010) N Engl J Med , vol.362 , pp. 402-415
    • Cohen, J.A.1    Barkhof, F.2    Comi, G.3
  • 32
    • 81155154918 scopus 로고    scopus 로고
    • Accessed March 2
    • http://www.clinicaltrials.gov. Accessed March 2, 2011.
    • (2011)
  • 33
    • 77954077611 scopus 로고    scopus 로고
    • 4-Aminopyri-dine: New life for an old drug
    • Hauser SL, Johnston SC. 4-Aminopyri-dine: new life for an old drug. Ann Neurol. 2010;68:A8-A9.
    • (2010) Ann Neurol , vol.68
    • Hauser, S.L.1    Johnston, S.C.2
  • 34
    • 78149478174 scopus 로고    scopus 로고
    • On behalf of the MSF204 Investigators. A phase 3 trial of extended release oral dalfampridine in multiple sclerosis
    • Goodman AD, Brown TR, Edwards KR, et al. On behalf of the MSF204 Investigators. A phase 3 trial of extended release oral dalfampridine in multiple sclerosis. Ann Neurol. 2010;68:494-502.
    • (2010) Ann Neurol , vol.68 , pp. 494-502
    • Goodman, A.D.1    Brown, T.R.2    Edwards, K.R.3
  • 35
    • 60649090430 scopus 로고    scopus 로고
    • On behalf of the Fampridine MS-F203 Investigators. Sustained-release oral fampridine in multiple sclerosis: A randomised, double-blind, controlled trial
    • Goodman AD, Brown TR, Krupp LB, et al. On behalf of the Fampridine MS-F203 Investigators. Sustained-release oral fampridine in multiple sclerosis: a randomised, double-blind, controlled trial. Lancet. 2009;373:732-738.
    • (2009) Lancet , vol.373 , pp. 732-738
    • Goodman, A.D.1    Brown, T.R.2    Krupp, L.B.3
  • 36
    • 34248380578 scopus 로고    scopus 로고
    • Cost-effectiveness of four immunomodulatory therapies for relapsing-remitting multiple sclerosis: A Markov model based on long-term clinical data
    • Bell C, Graham J, Earnshaw S, Oleen-Burkey M, Castelli-Haley J, Johnson K. Cost-effectiveness of four immunomodulatory therapies for relapsing-remitting multiple sclerosis: a Markov model based on long-term clinical data. J Manag Care Pharm. 2007;13:245-261.
    • (2007) J Manag Care Pharm , vol.13 , pp. 245-261
    • Bell, C.1    Graham, J.2    Earnshaw, S.3    Oleen-Burkey, M.4    Castelli-Haley, J.5    Johnson, K.6
  • 37
    • 70349878541 scopus 로고    scopus 로고
    • Comparing the cost-effectiveness of disease-modifying drugs for the flrst-line treatment of relapsingremitting multiple sclerosis
    • Goldberg LD, Edwards NC, Fincher C, Doan QU, Al-Sabbagh A, Meletiche DM. Comparing the cost-effectiveness of disease-modifying drugs for the flrst-line treatment of relapsingremitting multiple sclerosis. J Manag Care Pharm. 2009;15:543-555.
    • (2009) J Manag Care Pharm , vol.15 , pp. 543-555
    • Goldberg, L.D.1    Edwards, N.C.2    Fincher, C.3    Doan, Q.U.4    Al-Sabbagh, A.5    Meletiche, D.M.6
  • 38
    • 79952115015 scopus 로고    scopus 로고
    • Emerging oral agents for multiple sclerosis
    • Fox EJ. Emerging oral agents for multiple sclerosis. Am J Manag Care. 2010;16:S219-S226.
    • (2010) Am J Manag Care , vol.16
    • Fox, E.J.1
  • 39
    • 77956275980 scopus 로고    scopus 로고
    • Emerging oral therapies in multiple sclerosis
    • Conway D, Cohen JA. Emerging oral therapies in multiple sclerosis. Curr Neurol Neurosci Rep. 2010;10:381-388.
    • (2010) Curr Neurol Neurosci Rep , vol.10 , pp. 381-388
    • Conway, D.1    Cohen, J.A.2
  • 40
    • 77956649428 scopus 로고    scopus 로고
    • Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, infiammatory demyelination and acute axonal damage in mice with experimentalautoimmune encephalomyelitis
    • Wegner C, Stadelmann C, Pförtner R, et al. Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, infiammatory demyelination and acute axonal damage in mice with experimentalautoimmune encephalomyelitis. J Neuroimmunol. 2010;227:133-143.
    • (2010) J Neuroimmunol , vol.227 , pp. 133-143
    • Wegner, C.1    Stadelmann, C.2    Pförtner, R.3
  • 41
    • 45249107267 scopus 로고    scopus 로고
    • For the LAQ/5062 Study Group. Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase IIb study
    • Comi G, Pulizzi A, Rovaris M, et al. For the LAQ/5062 Study Group. Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet. 2008;371:2085-2092.
    • (2008) Lancet , vol.371 , pp. 2085-2092
    • Comi, G.1    Pulizzi, A.2    Rovaris, M.3
  • 43
    • 33645799680 scopus 로고    scopus 로고
    • On behalf of the Terifiunomide Multiple Sclerosis Trial Group and the University of British Columbia MS/ MRI Research Group. A phase II study of the safety and efflcacy of terifiunomide in multiple sclerosis with relapses
    • O'Connor PW, Li D, Freedman MS, et al. On behalf of the Terifiunomide Multiple Sclerosis Trial Group and the University of British Columbia MS/ MRI Research Group. A phase II study of the safety and efflcacy of terifiunomide in multiple sclerosis with relapses. Neurology. 2006;66:894-900.
    • (2006) Neurology , vol.66 , pp. 894-900
    • O'Connor, P.W.1    Li, D.2    Freedman, M.S.3
  • 44
    • 77951475881 scopus 로고    scopus 로고
    • Dimethyl fumarate (BG00012) inhibits astrocyte and microglial activation
    • Bista P, Ryan S, Hahm K, et al. Dimethyl fumarate (BG00012) inhibits astrocyte and microglial activation. Multiple Sclerosis. 2009;15:S132.
    • (2009) Multiple Sclerosis , vol.15
    • Bista, P.1    Ryan, S.2    Hahm, K.3
  • 45
    • 54149116366 scopus 로고    scopus 로고
    • For the BG-12 Phase IIb Study Investigators. Efflcacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: A multicentre, randomised, double-blind, placebo-controlled phase IIb study
    • Kappos L, Gold R, Miller DH, et al. For the BG-12 Phase IIb Study Investigators. Efflcacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet. 2008;372:1463-1472.
    • (2008) Lancet , vol.372 , pp. 1463-1472
    • Kappos, L.1    Gold, R.2    Miller, D.H.3
  • 46
    • 76149083915 scopus 로고    scopus 로고
    • For the CLARITY Study Group. A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis
    • Giovannoni G, Comi G, Cook S, et al. For the CLARITY Study Group. A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis. N Engl J Med. 2010;362:416-426.
    • (2010) N Engl J Med , vol.362 , pp. 416-426
    • Giovannoni, G.1    Comi, G.2    Cook, S.3
  • 47
    • 81155143753 scopus 로고    scopus 로고
    • Medscape website, Updated March 2, 2011. Accessed March 2
    • Gandey A. Medscape website. http://www.med-scape.com/viewarticle/738239. Updated March 2, 2011. Accessed March 2, 2011.
    • (2011)
    • Gandey, A.1


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