Effect of chronic intermittent hypoxia on exercise adaptations in healthy subjects

Respiratory Physiology and Neurobiology

Volumn 179, Issue 2-3, 2011, Pages 287-293

  Tonini, Julia ^a,b   Michallet, Anne Sophie ^a   Flore, Patrice ^a   Nespoulet, Hugo ^a   Pepin, Jean Louis ^a,b   Wuyam, Bernard ^a,b   Levy, Patrick ^a,b   Tamisier, Renaud ^a,b  

^a University Grenoble Alpes   (France)

^b GRENOBLE UNIVERSITY HOSPITAL   (France)

Author keywords

Cardiovascular; Exercise; Pathophysiology; Sleep apnoea; Substrate oxidation

Indexed keywords

LACTIC ACID;

ADULT; ARTERIAL PRESSURE; ARTICLE; CHRONIC INTERMITTENT HYPOXIA; DIASTOLIC BLOOD PRESSURE; END TIDAL CARBON DIOXIDE TENSION; EXERCISE; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LACTATE BLOOD LEVEL; LIPID OXIDATION; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

ADAPTATION, PHYSIOLOGICAL; ANOXIA; BLOOD PRESSURE; EXERCISE; EXERCISE TOLERANCE; FEMALE; HEART RATE; HEMODYNAMICS; HUMANS; LACTIC ACID; LIPID PEROXIDATION; MALE; PULMONARY VENTILATION; SLEEP APNEA, OBSTRUCTIVE; YOUNG ADULT;

EID: 81155139669     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2011.09.006     Document Type: Article

References (40)

1. Alonso-Fernandez A., Garcia-Rio F., Arias M.A., Mediano O., Pino J.M., Martinez I., Villamor J. Obstructive sleep apnoea-hypoapnoea syndrome reversibly depresses cardiac response to exercise. Eur. Heart J. 2006, 27:207-215.
2. Arnaud C., Dematteis M., Pepin J.L., Baguet J.P., Levy P. Obstructive sleep apnea, immuno-inflammation, and atherosclerosis. Semin. Immunopathol. 2009, 31:113-125.
3. Baguet J.-P., Hammer L., Levy P., Pierre H., Launois S., Mallion J.-M., Pepin J.-L. The severity of oxygen desaturation is predictive of carotid wall thickening and plaque occurrence. Chest 2005, 128:3407-3412.
4. Bang O. The lactate content of the blood during and after muscular exercise in man. Skand. Arch. Physiol. 1936, 74:49-82.
5. Bonanni E., Pasquali L., Manca M.L., Maestri M., Prontera C., Fabbrini M., Berrettini S., Zucchelli G., Siciliano G., Murri L. Lactate production and catecholamine profile during aerobic exercise in normotensive OSAS patients. Sleep Med. 2004, 5:137-145.
6. Brooks G.A., Mercier J. Balance of carbohydrate and lipid utilization during exercise: the "crossover" concept. J. Appl. Physiol. 1994, 76:2253-2261.
7. Brun J.F., Jean E., Ghanassia E., Flavier S., Mercier J. Metabolic training: new paradigms of exercise training for metabolic diseases with exercise calorimetry targeting individuals. Ann. Readapt. Med. Phys. 2007, 50:528-534. 520-527.
8. Cole C.R., Blackstone E.H., Pashkow F.J., Snader C.E., Lauer M.S. Heart-rate recovery immediately after exercise as a predictor of mortality. N. Engl. J. Med. 1999, 341:1351-1357.
9. Drager L.F., Bortolotto L.A., Figueiredo A.C., Krieger E.M., Lorenzi G.F. Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 2007, 176:706-712.
10. Ellis K., Pothier C.E., Blackstone E.H., Lauer M.S. Is systolic blood pressure recovery after exercise a predictor of mortality?. Am. Heart J. 2004, 147:287-292.
11. Fletcher E.C. Invited review: physiological consequences of intermittent hypoxia: systemic blood pressure. J. Appl. Physiol. 2001, 90:1600-1605.
12. Grote L., Hedner J., Peter J.H. The heart rate response to exercise is blunted in patients with sleep-related breathing disorder. Cardiology 2004, 102:93-99.
13. Grote L., Kraiczi H., Hedner J. Reduced alpha- and beta(2)-adrenergic vascular response in patients with obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 2000, 162:1480-1487.
14. Hansen J.E., Sue D.Y., Wasserman K. Predicted values for clinical exercise testing. Am. Rev. Respir. Dis. 1984, 129:S49-S55.
15. Hargens T.A., Guill S.G., Zedalis D., Gregg J.M., Nickols-Richardson S.M., Herbert W.G. Attenuated heart rate recovery following exercise testing in overweight young men with untreated obstructive sleep apnea. Sleep 2008, 31:104-110.
16. Iiyori N., Alonso L.C., Li J., Sanders M.H., Garcia-Ocana A., O'Doherty R.M., Polotsky V.Y., O'Donnell C.P. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am. J. Respir. Crit. Care Med. 2007, 175:851-857.
17. Kaleth A.S., Chittenden T.W., Hawkins B.J., Hargens T.A., Guill S.G., Zedalis D., Gregg J.M., Herbert W.G. Unique cardiopulmonary exercise test responses in overweight middle-aged adults with obstructive sleep apnea. Sleep Med. 2007, 8:160-168.
18. Li J., Thorne L.N., Punjabi N.M., Sun C.K., Schwartz A.R., Smith P.L., Marino R.L., Rodriguez A., Hubbard W.C., O'Donnell C.P., Polotsky V.Y. Intermittent hypoxia induces hyperlipidemia in lean mice. Circ. Res. 2005, 97:698-706.
19. Lin C.C., Hsieh W.Y., Chou C.S., Liaw S.F. Cardiopulmonary exercise testing in obstructive sleep apnea syndrome. Respir. Physiol. Neurobiol. 2006, 150:27-34.
20. Louis M., Punjabi N.M. Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers. J. Appl. Physiol. 2009, 106:1538-1544.
21. Maeder M.T., Ammann P., Munzer T., Schoch O.D., Korte W., Hurny C., Myers J., Rickli H. Continuous positive airway pressure improves exercise capacity and heart rate recovery in obstructive sleep apnea. Int. J. Cardiol. 2009, 132:75-83.
22. Maeder M.T., Munzer T., Rickli H., Schoch O.D., Korte W., Hurny C., Ammann P. Association between heart rate recovery and severity of obstructive sleep apnea syndrome. Sleep Med. 2008, 9:753-761.
23. Metz L., Sirvent P., Py G., Brun J.F., Fedou C., Raynaud E., Mercier J. Relationship between blood lactate concentration and substrate utilization during exercise in type 2 diabetic postmenopausal women. Metabolism 2005, 54:1102-1107.
24. Michallet A.S., Tonini J., Regnier J., Guinot M., Favre-Juvin A., Bricout V., Halimi S., Wuyam B., Flore P. Methodological aspects of crossover and maximum fat-oxidation rate point determination. Diabetes Metab. 2008, 34:514-523.
25. Nishime E.O., Cole C.R., Blackstone E.H., Pashkow F.J., Lauer M.S. Heart rate recovery and treadmill exercise score as predictors of mortality in patients referred for exercise ECG. JAMA 2000, 284:1392-1398.
26. O'Donnell C.P. Metabolic consequences of intermittent hypoxia. Adv. Exp. Med. Biol. 2007, 618:41-49.
27. Perez-Martin A., Dumortier M., Raynaud E., Brun J.F., Fedou C., Bringer J., Mercier J. Balance of substrate oxidation during submaximal exercise in lean and obese people. Diabetes Metab. 2001, 27:466-474.
28. Peronnet F., Massicotte D. Table of nonprotein respiratory quotient: an update. Can. J. Sport Sci. 1991, 16:23-29.
29. Pialoux V., Hanly P.J., Foster G.E., Brugniaux J.V., Beaudin A.E., Hartmann S.E., Pun M., Duggan C.T., Poulin M.J. Effects of exposure to intermittent hypoxia on oxidative stress and acute hypoxic ventilatory response in humans. Am. J. Respir. Crit. Care Med. 2009, 180:1002-1009.
30. Przybylowski T., Bielicki P., Kumor M., Hildebrand K., Maskey-Warzechowska M., Korczynski P., Chazan R. Exercise capacity in patients with obstructive sleep apnea syndrome. J. Physiol. Pharmacol. 2007, 58(Suppl 5):563-574.
31. Punjabi N.M., Shahar E., Redline S., Gottlieb D.J., Givelber R., Resnick H.E. Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am. J. Epidemiol. 2004, 160:521-530.
32. Sauleda J., Garcia-Palmer F.J., Tarraga S., Maimo A., Palou A., Agusti A.G. Skeletal muscle changes in patients with obstructive sleep apnoea syndrome. Respir. Med. 2003, 97:804-810.
33. Sidossis L.S., Wolfe R.R. Glucose and insulin-induced inhibition of fatty acid oxidation: the glucose-fatty acid cycle reversed. Am. J. Physiol. 1996, 270:E733-E738.
34. Tamisier R., Gilmartin G.S., Launois S.H., Pepin J.L., Nespoulet H., Thomas R., Levy P., Weiss J.W. A new model of chronic intermittent hypoxia in humans: effect on ventilation, sleep, and blood pressure. J. Appl. Physiol. 2009, 107:17-24.
35. Tamisier R., Pepin J.L., Remy J., Baguet J.P., Taylor J.A., Weiss J.W., Levy P. 14 nights of intermittent hypoxia elevate daytime blood pressure and sympathetic activity in healthy humans. Eur. Respir. J. 2011, 37:119-128.
36. Tryfon S., Stanopoulos I., Dascalopoulou E., Argyropoulou P., Bouros D., Mavrofridis E. Sleep apnea syndrome and diastolic blood pressure elevation during exercise. Respiration 2004, 71:499-504.
37. Vanuxem D., Badier M., Guillot C., Delpierre S., Jahjah F., Vanuxem P. Impairment of muscle energy metabolism in patients with sleep apnoea syndrome. Respir. Med. 1997, 91:551-557.
38. Verges S., Flore P., Laplaud D., Guinot M., Favre-Juvin A. Laboratory running test vs. field roller skiing test in cross-country skiers: a longitudinal study. Int. J. Sports Med. 2006, 27:307-313.
39. Vgontzas A.N., Bixler E.O., Chrousos G.P. Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med. Rev. 2005, 9:211-224.
40. Weissman M.L., Jones P.W., Oren A., Lamarra N., Whipp B.J., Wasserman K. Cardiac output increase and gas exchange at start of exercise. J. Appl. Physiol. 1982, 52:236-244.