11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertension

Prostaglandins and Other Lipid Mediators

Volumn 96, Issue 1-4, 2011, Pages 72-75

  Sacerdoti, David ^a   Jiang, Houli ^b   Gaiani, Silvia ^a   McGiff, John C ^b   Gatta, Angelo ^a   Bolognesi, Massimo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

20 Hydroxyeicosatetraenoic acid (20HETE); Arachidonic acid; Cirrhotic portal hypertension; Cytochrome P450; Epoxyeicosatrienoic acids (EET); Liver circulation

Indexed keywords

11,12 EPOXY 5,8,14 ICOSATRIENOIC ACID; 12,12 DIBROMODODECENOIC ACID; 20 HYDROXYICOSATETRAENOIC ACID; ARACHIDONIC ACID; ENDOTHELIN 1; EPOXYICOSATRIENOIC ACID; MICONAZOLE; PHENYLEPHRINE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; EXPERIMENTAL LIVER CIRRHOSIS; HEPATIC VEIN; ISOLATED LIVER; MALE; NONHUMAN; PERFUSION PRESSURE; PORTAL VEIN BLOOD FLOW; RAT; VASCULAR RESISTANCE;

8,11,14-EICOSATRIENOIC ACID; ANIMALS; ARACHIDONIC ACID; CARBON TETRACHLORIDE; CYTOCHROME P-450 ENZYME SYSTEM; ENDOTHELIN-1; HEPATIC VEINS; HYDROXYEICOSATETRAENOIC ACIDS; HYPERTENSION, PORTAL; INFUSION PUMPS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MICONAZOLE; ORGAN CULTURE TECHNIQUES; OXIDOREDUCTASES; PHENYLEPHRINE; PORTAL PRESSURE; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR RESISTANCE; VASOCONSTRICTION; VASODILATION;

EID: 81155133782     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2011.08.002     Document Type: Article

References (28)

1. J. Bosch, and J.C. Garcia-Pagan Complications of cirrhosis. I. Portal hypertension J Hepatol 32 2000 141 156 (Pubitemid 30123631)
2. T.K. Gupta, M. Toruner, M.K. Chung, and R.J. Groszmann Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats Hepatology 28 1998 926 931 (Pubitemid 28450251)
3. J. Bosch, V. Arroyo, and A. Betriu Hepatic hemodynamics and the renin-angiotensin-aldosterone system in cirrhosis Gastroenterology 78 1980 92 99 (Pubitemid 10216855)
4. A. Leivas, W. Jimenez, and J. Bruix Gene expression of endothelin-1 and ET(A) and ET(B) receptors in human cirrhosis: relationship with hepatic hemodynamics J Vasc Res 35 1998 186 193 (Pubitemid 28270826)
5. R. Wiest, and R.J. Groszmann Nitric oxide and portal hypertension: its role in the regulation of intrahepatic and splanchnic vascular resistance Semin Liver Dis 19 1999 411 426 (Pubitemid 30032642)
6. A.A. Spector Arachidonic acid cytochrome P450 epoxygenase pathway J Lipid Res 50 Suppl 2009 S52 S56
7. S.L. Pfister, K.M. Gauthier, and W.B. Campbell Vascular pharmacology of epoxyeicosatrienoic acids Adv Pharmacol 60 2010 27 59
8. R.J. Roman P-450 metabolites of arachidonic acid in the control of cardiovascular function Physiol Rev 82 2002 131 185 (Pubitemid 34654217)
9. D. Sacerdoti, M. Bolognesi, and M. Di Pascoli Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase Am J Physiol Heart Circ Physiol 291 4 2006 H1999 H2002
10. B. Escalante, D. Sacerdoti, M.M. Davidian, M. Laniado-Schwartzman, and J.C. McGiff Chronic treatment with tin normalizes blood pressure in spontaneously hypertensive rats Hypertension 17 6 (Pt 1) 1991 776 779
11. A.O. Oyekan, and J.C. McGiff Cytochrome P-450-derived eicosanoids participates in the renal functional effects of ET-1 in the anaesthetized rat Am J Physiol 274 1988 R52 R61
12. A. Sarkis, B. Lopez, and R.J. Roman Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension Curr Opin Nephrol Hypertens 13 2004 205 214 (Pubitemid 38373143)
13. D. Sacerdoti, M. Balazy, P. Angeli, A. Gatta, and J.C. McGiff Eicosanoid excretion in hepatic cirrhosis: predominance of 20-HETE J Clin Invest 100 1997 1264 1270 (Pubitemid 27386313)
14. F.J. Gonzalez, and Y.H. Lee Constitutive expression of hepatic cytochrome P450 genes FASEB J 10 10 1996 1112 1117 (Pubitemid 26276953)
15. A.B. Rifkind, C. Lee, T.K. Chang, and D.J. Waxman Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes Arch Biochem Biophys 320 2 1995 380 389
16. D. Sacerdoti, B.A. Escalante, M.L. Schwartzman, N.G. Abraham, A. Gatta, and J.C. McGiff Renal cytochrome P-450-dependent metabolism of arachidonic acid in cirrhotic rats J Hepatol 12 2 1991 230 235
17. E. Proctor, and K. Chatamra Controlled induction of cirrhosis in the rat Br J Exp Pathol 64 3 1983 320 330 (Pubitemid 13037192)
18. Z.M. Chu, K.D. Croft, D.A. Kingsbury, J.R. Falck, K.M. Reddy, and L.J. Beilin Cytochrome P450 metabolites of arachidonic acid may be important mediators in angiotensin II-induced vasoconstriction in the rat mesentery in vivo Clin Sci 98 2000 277 282 (Pubitemid 30145233)
19. M.H. Wang, E. Brand-Schieber, and B.A. Zand Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: characterization of selective inhibitors Pharmacol Exp Ther 284 3 1998 966 973 (Pubitemid 28130824)
20. H. Jiang, J.C. McGiff, and J. Quilley Identification of 5,6-trans-epoxyeicosatrienoic acid in the phospholipids of red blood cells J Biol Chem 279 2004 36412 36418 (Pubitemid 39128980)
21. P.S. Bhathal, and H.J. Grossman Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators J Hepatol 1 1985 325 337 (Pubitemid 15044203)
22. J. Bosch, J.G. Abraldes, M. Fernández, and J.C. García-Pagán Hepatic endothelial dysfunction and abnormal angiogenesis: new targets in the treatment of portal hypertension J Hepatol 53 3 2010 558 567
23. M. Graupera, J.C. García-Pagán, and M. Parés Cyclooxygenase-1 inhibition corrects endothelial dysfunction in cirrhotic rat livers J Hepatol 39 4 2003 515 521 (Pubitemid 37204650)
24. J. Gracia-Sancho, B. Laviña, A. Rodríguez-Vilarrupla, H. García-Calderó, J. Bosch, and J.C. García-Pagán Enhanced vasoconstrictor prostanoid production by sinusoidal endothelial cells increases portal perfusion pressure in cirrhotic rat livers J Hepatol 47 2 2007 220 227 (Pubitemid 47028585)
25. W.B. Campbell, J.R. Falck, and K. Gauthier Role of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factor in bovine coronary arteries Med Sci Monit 7 4 2001 578 584 (Pubitemid 32691731)
26. W.B. Campbell, and I. Fleming Epoxyeicosatrienoic acids and endothelium-dependent responses Pflugers Arch 459 6 2010 881 895
27. D. Zhu, and M. Bousamra 2nd Epoxyeicosatrienoic acids constrict isolated pressurized rabbit pulmonary arteries Am J Physiol Lung Cell Mol Physiol 278 2 2000 L335 L343
28. B. Keserü, E. Barbosa-Sicard, and R. Popp Epoxyeicosatrienoic acids and the soluble epoxide hydrolase are determinants of pulmonary artery pressure and the acute hypoxic pulmonary vasoconstrictor response FASEB J 22 12 2008 4306 4315