Tagetitoxin inhibits RNA polymerase through trapping of the trigger loop

Journal of Biological Chemistry

Volumn 286, Issue 46, 2011, Pages 40395-40400

  Artsimovitch, Irina ^a   Svetlov, Vladimir ^b   Nemetski, Sondra Maureen ^b   Epshtein, Vitaly ^b   Cardozo, Timothy ^b   Nudler, Evgeny ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ARG RESIDUES; CRYSTALLOGRAPHIC STRUCTURE; ELONGATION COMPLEX; MULTISUBUNIT; RNA POLYMERASE; STRUCTURAL MODELS;

CHLOROPHYLL; MODEL STRUCTURES;

RNA;

ALANINE; ANTIBIOTIC AGENT; ARGININE; ASPARAGINE; RNA POLYMERASE; TAGETITOXIN; TRANSCRIPTION ELONGATION FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BETA CHAIN; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

BACTERIAL PROTEINS; DICARBOXYLIC ACIDS; DNA-DIRECTED RNA POLYMERASES; MODELS, MOLECULAR; ORGANOPHOSPHORUS COMPOUNDS; PROTEIN STRUCTURE, SECONDARY; THERMUS THERMOPHILUS;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 81155132249     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.300889     Document Type: Article

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