A new perspective on the Dunnett procedure: Filling the gap between NOEC/LOEC and ECx concepts

Environmental Toxicology and Chemistry

Volumn 30, Issue 12, 2011, Pages 2888-2891

  Delignette Muller, Marie Laure ^a,c   Forfait, Carole ^a   Billoir, Elise ^a,b   Charles, Sandrine ^a  

^a UNIVERSITÉ DE LYON   (France)

^b Pôle de Recherche ROVALTAIN en Toxicologie Environnementale et Ecotoxicologie   (France)

^c VETAGRO SUP   (France)

Author keywords

Ecotoxicological bioassays; Multiple comparisons; Simultaneous confidence intervals; Toxicity endpoints

Indexed keywords

CONFIDENCE INTERVAL; ECOTOXICOLOGICAL TESTS; EFFECTIVE CONCENTRATION; HYPOTHESIS TESTS; MULTIPLE COMPARISON; SIMULTANEOUS CONFIDENCE INTERVALS;

CHEMISTRY;

ENVIRONMENTAL IMPACT;

BIOASSAY; CONCENTRATION (COMPOSITION); ECOTOXICOLOGY; TOXICITY;

ARTICLE; CONFIDENCE INTERVAL; ECOTOXICOLOGY; PRIORITY JOURNAL;

ANIMALS; CONFIDENCE INTERVALS; DAPHNIA; ECOTOXICOLOGY; ENVIRONMENTAL POLLUTANTS; NO-OBSERVED-ADVERSE-EFFECT LEVEL; TOXICITY TESTS;

EID: 81155128687     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.686     Document Type: Article

References (22)

1. Organisation for Economic Co-operation and Development. 2006. Series on Testing and Assessment Number 54. Current approaches in the statistical analysis of ecotoxicity data: A guidance to application. OECD Environment Health and Safety Publications, Paris, France.
2. van der Hoeven N. 1997. How to measure no effect? Part III: Statistical aspects of NOEC, ECx and NEC estimates. Environmetrics 8: 255-261.
3. Fox DR. 2008. NECs, NOECs and the ECx. Aust J Ecotoxicol 14: 7-9.
4. Newman MC. 2008. "What exactly are you inferring?" A closer look at hypothesis testing. Environ Toxicol Chem 27: 1013-1019.
5. Warne MSJ, van Dam R. 2008. NOEC and LOEC data should no longer be generated or used. Aust J Ecotoxicol 14: 1-5.
6. Altman DG, Bland JM. 1995. Absence of evidence is not evidence of absence. Br Med J 311: 495.
7. Armstrong JS. 2007. Significance tests harm progress in forecasting. Int J Forecasting 23: 321-327.
8. Gardner MJ, Altman DG. 1986. Confidence intervals rather than P values: Estimation rather than hypothesis testing. Br Med J 292: 746-750.
9. U.S. Food and Drug Administration. 2001. Guidance for industry: Statistical Approaches to Establishing Bioequivalence and hazardous concentration in ecotoxicology. Washington, DC.
10. Dilba G, Bretz F, Guiard V, Hothorn LA. 2004. Simultaneous confidence intervals for ratios with applications to the comparison of several treatments with a control. Methods Inf Med 43: 465-469.
11. Hothorn T, Bretz F, Westfall P., 2008. Simultaneous inference in general parametric models. Biometrical J 50: 346-363.
12. R Development Core Team. 2011. R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria.
13. Brain P, Cousens R. 1989. An equation to describe dose responses where there is stimulation of growth at low dose. Weed Res 29: 93-96.
14. Ritz C, Streibig JC., 2005. Bioassay Analysis using R. J Stat Softw 12: 1-22.
15. Billoir E, Delignette-Muller ML, Péry AR, Charles S. 2008. A Bayesian approach to analyzing ecotoxicological data. Environ Sci Technol 42: 8978-8984.
16. Manar R, Bessy H, Vasseur P. 2009. Reproductive effects and bioaccumulation of chlordane in Daphnia magna. Environ Toxicol Chem 28: 2150-2159.
17. Isnard P, Flammarion P, Roman G, Babut M, Bastien P, Bintein S, Esserméant L, Férard JF, Gallotti-Schmitt S, Saouter E, Saroli M, Thiébaud H, Tomassone R, Vindimian E. 2001. Statisical analysis of regulatory ecotoxicity tests. Chemosphere 45: 659-669.
18. Moore DRJ, Caux PY. 1997. Estimating low toxic effects. Environ Toxicol Chem 16: 794-801.
19. van der Hoeven N. 2008. Calculation of the minimum significant difference at the NOEC using a non-parametric test. Ecotoxicol Environ Saf 70: 61-66.
20. van der Hoeven N. 2004. Current issues in statistics and models for ecotoxicological risk assessment. Acta Biotheor 52: 201-217.
21. Kooijman S, Bedaux J., 1996. The Analysis of Aquatic Toxicity Data. VU University Press, Amsterdam, The Netherlands.
22. Fox DR. 2010. A Bayesian approach for determining the no effect concentration Ecotoxicol Environ Saf 73: 123-131.