Rats subjected to chronic-intermittent hypoxia have increased density of noradrenergic terminals in the trigeminal sensory and motor nuclei

Neuroscience Letters

Volumn 505, Issue 2, 2011, Pages 176-179

  Mody, Pari ^a   Rukhadze, Irma ^a   Kubin, Leszek ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cranial muscles; Motoneurons; Norepinephrine; Obstructive sleep apnea; Respiratory plasticity

Indexed keywords

DOPAMINE BETA MONOOXYGENASE; OXYGEN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CHRONIC INTERMITTENT HYPOXIA; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; HYPOXIA; IMMUNOHISTOCHEMISTRY; MALE; MOTONEURON NUCLEUS; NONHUMAN; NORADRENERGIC NERVE; OSCILLATION; PRIORITY JOURNAL; RAT; TRIGEMINAL NERVE;

ANIMALS; DISEASE MODELS, ANIMAL; HYPOXIA, BRAIN; MALE; MOTOR NEURONS; NOREPINEPHRINE; PRESYNAPTIC TERMINALS; RATS; RATS, SPRAGUE-DAWLEY; SENSORY RECEPTOR CELLS; TRIGEMINAL NERVE DISEASES; TRIGEMINAL NUCLEI;

EID: 81055155823     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.10.015     Document Type: Article

References (29)

1. Aldes L.D., Chronister R.B., Shelton C.I., Haycock J.W., Marco L.A., Wong D.L. Catecholamine innervation of the rat hypoglossal nucleus. Brain Res. Bull. 1988, 21:305-312.
2. Chan E., Steenland H.W., Liu H., Horner R.L. Endogenous excitatory drive modulating respiratory muscle activity across sleep-wake states. Am. J. Respir. Crit. Care Med. 2006, 174:1264-1273.
3. Dematteis M., Godin-Ribuot D., Arnaud C., Ribuot C., Stanke-Labesque F., Pepin J.L., Levy P. Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding the human disease. ILAR J. 2009, 50:262-281.
4. Dempsey J.A., Veasey S.C., Morgan B.J., O'Donnell C.P. Pathophysiology of sleep apnea. Physiol. Rev. 2010, 90:47-112.
5. Dutschmann M., Paton J.F.R. Influence of nasotrigeminal afferents on medullary respiratory neurones and upper airway patency in the rat. Pflügers Arch. 2002, 444:227-235.
6. Fenik V.B., Davies R.O., Kubin L. REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs. Am. J. Respir. Crit. Care Med. 2005, 172:1322-1330.
7. Fletcher E.C. Effect of episodic hypoxia on sympathetic activity and blood pressure. Respir. Physiol. 2000, 119:189-197.
8. Furuta T., Urbain N., Kaneko T., Deschêns M. Corticofugal control of vibrissa-sensitive neurons in the interpolaris nucleus of the trigeminal complex. J. Neurosci. 2010, 30:1832-1838.
9. Grzanna R., Chee W.K., Akeyson E.W. Noradrenergic projections to brainstem nuclei: evidence for differential projections from noradrenergic subgroups. J. Comp. Neurol. 1987, 263:76-91.
10. Iiyori N., Alonso L.C., Li J., Sanders M.H., Garcia-Ocana A., O'Doherty R.M., Polotsky V.Y., O'Donnell C.P. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am. J. Respir. Crit. Care Med. 2007, 175:851-857.
11. Jordan D., Wood L.M. A convergent input from nasal receptors and the larynx to the rostral sensory trigeminal nuclei of the cat. J. Physiol. (Lond.) 1987, 393:147-155.
12. Koeda S., Ishii H., Kuchiiwa S., Izumi H. Role of the spinal trigeminal nucleus in the rat autonomic reflex. Arch. Oral Biol. 2009, 54:1136-1142.
13. Kubin L., Davies R.O. Mechanisms of airway hypotonia. Sleep Apnea. Pathogenesis, Diagnosis, and Treatment 2002, 99-154. Dekker, New York. A.I. Pack (Ed.).
14. Mezzanotte W.S., Tangel D.J., White D.P. Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism). J. Clin. Invest. 1992, 89:1571-1579.
15. Mody P., Rukhadze I., Kubin L. Rats subjected to chronic-intermittent hypoxia (CIH) have increased density of noradrenergic terminals in the trigeminal sensory (Sp5) and motor (Mo5) nuclei. Sleep 2011, 34(Suppl.):A32. (Abstract 0083).
16. Neverova N.V., Saywell S.A., Nashold L.J., Mitchell G.S., Feldman J.L. Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability. J. Neurosci. 2007, 27:4435-4442.
17. Panneton W.M., McCulloch P.F., Sun W. Trigemino-autonomic connections in the muskrat: the neural substrate for the diving response. Brain Res. 2000, 874:48-65.
18. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1986, Academic Press, Sydney. 2nd ed.
19. Peppard P.E., Young T., Palta M., Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. N. Engl. J. Med. 2000, 342:1378-1384.
20. Remmers J.E., DeGroot W.J., Sauerland E.K., Anch A.M. Pathogenesis of upper airway occlusion during sleep. J. Appl. Physiol. 1978, 44:931-938.
21. Rukhadze I., Fenik V.B., Benincasa K.E., Price A., Kubin L. Chronic intermittent hypoxia alters density of aminergic terminals and receptors in the hypoglossal motor nucleus. Am. J. Respir. Crit. Care Med. 2010, 182:1321-1329.
22. Rukhadze I., Kubin L. Differential pontomedullary catecholaminergic projections to hypoglossal motor nucleus and viscerosensory nucleus of the solitary tract. J. Chem. Neuroanat. 2007, 33:23-33.
23. Schwartz A.R., Thut D.C., Russ B., Seelagy M., Yuan X., Brower R.G., Permutt S., Wise R.A., Smith L.P. Effect of electrical stimulation of the hypoglossal nerve on airflow mechanics in the isolated upper airway. Am. J. Respir. Crit. Care Med. 1993, 147:1144-1150.
24. Schwarz P.B., Yee N., Mir S., Peever J.H. Noradrenaline triggers muscle tone by amplifying glutamate-driven excitation of somatic motoneurones in anaesthetized rats. J. Physiol. (Lond.) 2008, 586:5787-5802.
25. Somers V.K., Dyken M.E., Clary M.P., Abboud F.M. Sympathetic neural mechanisms in obstructive sleep apnea. J. Clin. Invest. 1995, 96:1897-1904.
26. Suratt P.M., McTier R.F., Wilhoit S.C. Upper airway muscle activation is augmented in patients with obstructive sleep apnea compared with that in normal subjects. Am. Rev. Respir. Dis. 1988, 137:889-894.
27. Tadjalli A., Duffin J., Peever J. Identification of a novel form of noradrenergic-dependent respiratory motor plasticity triggered by vagal feedback. J. Neurosci. 2010, 30:16886-16895.
28. Weiss J.W., Liu M.D., Huang J. Physiological basis for a causal relationship of obstructive sleep apnoea to hypertension. Exp. Physiol. 2007, 92:21-26.
29. Zhu Y., Fenik P., Zhan G., Mazza E., Kelz M., Aston-Jones G., Veasey S.C. Selective loss of catecholaminergic wake active neurons in a murine sleep apnea model. J. Neurosci. 2007, 27:10060-10071.