αV integrin processing interferes with the cross-talk between αvβ5/β6 and α2β1 integrins

Biology of the Cell

Volumn 103, Issue 11, 2011, Pages 519-529

  Defilles, Céline ^a,b,d   Montero, Marie Pierre ^a,b   Lissitzky, Jean Claude ^a,b   Rome, Sophie ^c   Siret, Carole ^a,b   Luis, José ^a,b   André, Frédéric ^a,b   Rigot, Véronique ^a,b  

^a University of the Mediterranean Aix Marseille II   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c INSERM   (France)

^d ICNE   (France)

Author keywords

Cell migration; Convertase; Cross talk; Endoproteolytic cleavage; Integrin activation; Phosphoinositide 3 kinase (PI3K)

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHAVBETA5 INTEGRIN; ALPHAVBETA6 INTEGRIN; CD51 ANTIGEN; COLLAGEN TYPE 1; FOCAL ADHESION KINASE; MITOGEN ACTIVATED PROTEIN KINASE; VERY LATE ACTIVATION ANTIGEN 2;

ARTICLE; CELL MIGRATION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; UPREGULATION;

ALPHA 1-ANTITRYPSIN; ANTIGENS, NEOPLASM; CELL ADHESION; CELL MOVEMENT; COLLAGEN TYPE I; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INTEGRIN ALPHA2BETA1; INTEGRIN ALPHAV; INTEGRINS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, VITRONECTIN; SIGNAL TRANSDUCTION;

EID: 81055148256     PISSN: 02484900     EISSN: 1768322X     Source Type: Journal    
DOI: 10.1042/BC20100147     Document Type: Article

References (24)

1. Abair, T.D., Sundaramoorthy, M., Chen, D., Heino, J., Ivaska, J., Hudson, B.G., Sanders, C.R., Pozzi, A. and Zent, R. (2008) Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells. Exp. Cell Res. 314, 3593-3604
2. Baciu, P.C., Suleiman, E.A., Deryugina, E.I. and Strongin, A.Y. (2003) Membrane type-1 matrix metalloproteinase (MT1-MMP) processing of pro-alphav integrin regulates cross-talk between alphavbeta3 and alpha2beta1 integrins in breast carcinoma cells. Exp Cell Res. 291, 167-175
3. Berrier, A.L. and Yamada, K.M. (2007) Cell-matrix adhesion. J. Cell Physiol. 213, 565-573
4. Berthet, V., Rigot, V., Champion, S., Secchi, J., Fouchier, F., Marvaldi, J. and Luis, J. (2000) Role of endoproteolytic processing in the adhesive and signaling functions of alphavbeta5 integrin. J. Biol. Chem. 275, 33308-33313
5. Berthet, V., Rigot, V., Nejjari, M., Marvaldi, J. and Luis, J. (2004) The endoproteolytic processing of alphavbeta5 integrin is involved in cytoskeleton remodelling and cell migration. FEBS Lett. 557, 159-163
6. Bouvard, D. and Block, M.R. (1998) Calcium/calmodulin-dependent protein kinase II controls integrin alpha5beta1-mediated cell adhesion through the integrin cytoplasmic domain associated protein-1alpha. Biochem. Biophys. Res. Commun. 252, 46-50
7. Calderwood, D.A., Tai, V., Di, Paolo, G., De, Camilli, P. and Ginsberg, M.H. (2004) Competition for talin results in trans-dominant inhibition of integrin activation. J. Biol. Chem. 279, 28889-28895
8. Defilles, C., Lissitzky, J.C., Montero, M.P., Andre, F., Prevot, C., Delamarre, E., Marrakchi, N., Luis, J. and Rigot, V. (2009) alphavbeta5/beta6 integrin suppression leads to a stimulation of alpha2beta1 dependent cell migration resistant to PI3K/Akt inhibition. Exp. Cell Res. 315, 1840-1849
9. Delwel, G.O., Hogervorst, F. and Sonnenberg, A. (1996) Cleavage of the alpha6A subunit is essential for activation of the alpha6Abeta1 integrin by phorbol 12-myristate 13-acetate. J. Biol. Chem. 271, 7293-7296
10. Deryugina, E.I., Ratnikov, B.I., Postnova, T.I., Rozanov, D.V. and Strongin, A.Y. (2002) Processing of integrin alpha(v) subunit by membrane type 1 matrix metalloproteinase stimulates migration of breast carcinoma cells on vitronectin and enhances tyrosine phosphorylation of focal adhesion kinase. J. Biol. Chem. 277, 9749-9756
11. Geiger, B., Spatz, J.P. and Bershadsky, A.D. (2009) Environmental sensing through focal adhesions. Nat. Rev. Mol. Cell Biol. 10, 21-33
12. Gonzalez, A.M., Bhattacharya, R., deHart, G.W. and Jones, J.C. (2009) Transdominant regulation of integrin function: mechanisms of cross-talk. Cell Signal. 22, 578-583
13. Kappert, K., Furundzija, V., Fritzsche, J., Margeta, C., Kruger, J., Meyborg, H., Fleck, E. and Stawowy, P. (2010) Integrin cleavage regulates bidirectional signalling in vascular smooth muscle cells. Thromb. Haemostasis 103, 556-563
14. Kolodziej, M.A., Vilaire, G., Gonder, D., Poncz, M. and Bennett, J.S. (1991) Study of the endoproteolytic cleavage of platelet glycoprotein IIb using oligonucleotide-mediated mutagenesis. J. Biol. Chem. 266, 23499-23504
15. Lalou, C., Scamuffa, N., Mourah, S., Plassa, F., Podgorniak, M.P., Soufir, N., Dumaz, N., Calvo, F., Basset-Seguin, N. and Khatib, A.M. (2010) Inhibition of the proprotein convertases represses the invasiveness of human primary melanoma cells with altered p53, CDKN2A and N-Ras genes. PLoS One 5, e9992
16. Lehmann, M., Rabenandrasana, C., Tamura, R., Lissitzky, J.C., Quaranta, V., Pichon, J. and Marvaldi, J. (1994) A monoclonal antibody inhibits adhesion to fibronectin and vitronectin of a colon carcinoma cell line and recognizes the integrins alpha v beta 3, alpha v beta 5, and alpha v beta 6. Cancer Res. 54, 2102-2107
17. Lissitzky, J.C., Luis, J., Munzer, J.S., Benjannet, S., Parat, F., Chretien, M., Marvaldi, J. and Seidah, N.G. (2000) Endoproteolytic processing of integrin pro-alpha subunits involves the redundant function of furin and proprotein convertase (PC) 5A, but not paired basic amino acid converting enzyme (PACE) 4, PC5B or PC7. Biochem. J. 346 Pt 1, 133-138
18. Lunt, S.J., Chaudary, N. and Hill, R.P. (2008) The tumor microenvironment and metastatic disease. Clin. Exp. Metastasis 26, 19-34
19. Monferran, S., Skuli, N., Delmas, C., Favre, G., Bonnet, J., Cohen-Jonathan-Moyal, E. and Toulas, C. (2008) Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB. Int. J. Cancer 123, 357-364
20. Nejjari, M., Berthet, V., Rigot, V., Laforest, S., Jacquier, M.F., Seidah, N.G., Remy, L., Bruyneel, E., Scoazec, J.Y., Marvaldi, J. and Luis, J. (2004) Inhibition of proprotein convertases enhances cell migration and metastases development of human colon carcinoma cells in a rat model. Am. J. Pathol. 164, 1925-1933
21. Rathinam, R. and Alahari, S.K. (2010) Important role of integrins in the cancer biology. Cancer Metastasis Rev. 29, 223-237
22. Streuli, C.H. and Akhtar, N. (2009) Signal co-operation between integrins and other receptor systems. Biochem. J. 418, 491-506
23. Teixido, J., Parker, C.M., Kassner, P.D. and Hemler, M.E. (1992) Functional and structural analysis of VLA-4 integrin alpha 4 subunit cleavage. J. Biol. Chem. 267, 1786-1791
24. Wang, Y., Cao, H., Chen, J. and McNiven, M.A. (2011) A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src. Mol. Biol. Cell 22, 1529-1538