Testing an aetiological model of visual hallucinations in Parkinson's disease

Brain

Volumn 134, Issue 11, 2011, Pages 3299-3309

  Gallagher, David A ^a,b   Parkkinen, Laura ^a   O'Sullivan, Sean S ^a,b   Spratt, Alexander ^c   Shah, Ameet ^c   Davey, Clare C ^c   Bremner, Fion D ^a,b,c   Revesz, Tamas ^a   Williams, David R ^a,b,d   Lees, Andrew J ^a,b   Schrag, Anette ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL HOSPITAL FOR NEUROLOGY AND NEUROSURGERY   (United Kingdom)

^c ROYAL FREE LONDON NHS FOUNDATION TRUST   (United Kingdom)

^d MONASH UNIVERSITY   (Australia)

Author keywords

autonomic dysfunction; cognitive deficits; ophthalmology; Parkinson's disease; pathology; sleep disorders; visual hallucinations

Indexed keywords

AGED; ARTICLE; AUTONOMIC DYSFUNCTION; BEHAVIOR DISORDER; BRAIN CORTEX; COGNITION; DIFFUSE LEWY BODY DISEASE; DISEASE DURATION; DISEASE SEVERITY; EYE EXAMINATION; FEMALE; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; MOOD; MOOD DISORDER; MOTOR PERFORMANCE; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; REM SLEEP; SLEEP; SLEEP DISORDER; SOMNOLENCE; TREATMENT DURATION; VISION; VISUAL HALLUCINATION;

EID: 81055147637     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awr225     Document Type: Article

References (65)

1. Aarsland D, Larsen JP, Cummins JL, Laake K. Prevalence and clinical correlates of psychotic symptoms in Parkinson disease: a community-based study. Arch Neurol 1999; 56: 595-601. (Pubitemid 29218155)
2. American Academy of Sleep Medicine. The international classification of sleep disorders, revised: diagnostic and coding manual. American Academy of Sleep Medicine 2001, Rochester, MN.
3. Barnes J, Boubert L, Harris J, Lee A, David AS. Reality monitoring and visual hallucinations in Parkinson's disease. Neuropsychologia 2003; 41: 565-74. (Pubitemid 36143684)
4. Benke T. Peduncular hallucinosis: a syndrome of impaired reality monitoring. J Neurol 2006; 253: 1561-71. (Pubitemid 46115437)
5. Boecker H, Ceballos-Baumann AO, Volk D, Conrad B, Forstl H, Haussermann P. Metabolic alterations in patients with Parkinson disease and visual hallucinations. Arch Neurol 2007; 64: 984-8. (Pubitemid 47047998)
6. Braak H, Del Tredici K, Rü b U, de Vos RA, Jansen Steur EN, Braak E. Staging of brain pathology related to sporadic Parkinson's disease. Neurobiol Aging 2003; 24: 197-211. (Pubitemid 36007810)
7. Bright P, Moss HE, Stamatakis EA, Tyler LK. The anatomy of object processing: the role of anteromedial temporal cortex. Q J Exp Psychol B 2005; 58: 361-77. (Pubitemid 41158264)
8. Catani M, Jones DK, Donato R, Ffytche DH. Occipito-temporal connections in the human brain. Brain 2003; 126: 2093-107. (Pubitemid 37059449)
9. Comella CL, Tanner CM, Ristanovic RK. Polysomnographic sleep measures in Parkinson's disease patients with treatment-induced hallucinations. Ann Neurol 1993; 34: 710-4. (Pubitemid 23333244)
10. Diederich NJ, Goetz CG, Stebbins GT. Repeated visual hallucinations in Parkinson's disease as disturbed external/internal perceptions: focused review and a new integrative model. Mov Disord 2005; 20: 130-40. (Pubitemid 40361115)
11. Diederich NJ, Fé nelon G, Stebbins G, Goetz CG. Hallucinations in Parkinson disease. Nat Rev Neurol 2009; 5: 331-42.
12. Diederich NJ, Goetz CG, Raman R, Pappert EJ, Leurgans S, Piery V. Poor visual discrimination and visual hallucinations in Parkinson's disease. Clin Neuropharmacol 1998; 21: 289-95. (Pubitemid 28491429)
13. Dubois B, Slachevsky A, Litvan I, Pillon B. The FAB: a frontal assessment battery at bedside. Neurology 2000; 55: 1621-6.
14. Fahn S, Elton RL. Members of the UPDRS Development Committee. Unified Parkinson's disease rating scale. Florham Park NJ: MacMillan Healthcare Information; 1987. p. 153-63.
15. Fé nelon G, Alves G. Epidemiology of psychosis in Parkinson's disease. J Neurol Sci 2010, 289, 12-17.
16. Fé nelon G, Mahieux F, Huon R, Ziégler M. Hallucinations in Parkinson's disease. Prevalence, phenomenology and risk factors. Brain 2000; 123: 733-45.
17. Gibb WR, Lees AJ. The significance of the Lewy body in the diagnosis of idiopathic Parkinson's disease. Neuropathol Appl Neurobiol 1989; 15: 27-44. (Pubitemid 19074096)
18. Goetz CG, Diederich NJ, Fenelon G. Psychosis in Parkinson's disease. In: Chaudhuri KR, Tolosa E, Schapira A, Poewe W, editors. Non-motor symptoms of Parkinson's disease. New York: Oxford University Press; 2009. p. 147-163.
19. Grossi D, Trojano L, Pellecchia MT, Amboni M, Fragassi NA, Barone P. Frontal dysfunction contributes to the genesis of hallucinations in non-demented Parkinsonian patients. Int J Geriatr Psychiatry 2005; 20: 668-73. (Pubitemid 41131778)
20. Harding AJ, Broe GA, Halliday GM. Visual hallucinations in Lewy body disease relate to Lewy bodies in the temporal lobe. Brain 2002a; 125: 391-403. (Pubitemid 34127441)
21. Harding AJ, Stimson E, Henderson JM, Halliday GM. Clinical correlates of selective pathology in the amygdala of patients with Parkinson's disease. Brain 2002b; 125 (Pt 11): 2431-45. (Pubitemid 35303503)
22. Henkel LA, Johnson MK, De Leonardis DM. Aging and source monitoring: cognitive processes and neuropsychological correlates. J Exp Psychol Gen 1998; 127: 251-68. (Pubitemid 128460245)
23. Holroyd S, Currie L, Wooten GF. Prospective study of hallucinations and delusions in Parkinson's disease. J Neurol Neurosurg Psychiatry 2001; 70: 734-8. (Pubitemid 32554202)
24. Humphreys GW, Riddoch MJ, Price CJ. Top-down processes in object identification: evidence from experimental psychology, neuropsych-ology and functional anatomy. Philos Trans R Soc Lond B Biol Sci 1997; 352: 1275-82. (Pubitemid 27393110)
25. Ince PG, Clark B, Holton JL, Revesz T, Wharton SB. Disorders of movement and system degenerations. In: Love S, Louis DN, Ellison DW, editors. Greenfield's Neuropathology. 8th edn. London: Edward Arnold (Publishers) Ltd; 2008. p. 889-1030.
26. Jellinger KA. Formation and development of Lewy pathology: a critical update. J Neurol 2009; 256(Suppl 3): 270-9.
27. Kalaitzakis ME, Christian LM, Moran LB, Graeber MB, Pearce RK, Gentleman SM. Dementia and visual hallucinations associated with limbic pathology in Parkinson's disease. Parkinsonism Relat Disord 2009; 15: 196-204.
28. Kalia M. Neurobiology of sleep. Metabolism 2006; 55(10 Suppl 2): S2-6. (Pubitemid 44354947)
29. Kempster PA, O'Sullivan SS, Holton JL, Revesz T, Lees AJ. Relationships between age and late progression of Parkinson's disease: a clinico-pathological study. Brain 2010; 133: 1755-62.
30. Kitayama M, Wada-Isoe K, Irizawa Y, Nakashima K. Association of visual hallucinations with reduction of MIBG cardiac uptake in Parkinson's disease. J Neurol Sci 2008; 264: 22-6. (Pubitemid 350193242)
31. Manni R, Pacchetti C, Terzaghi M, Sartori I, Mancini F, Nappi G. Hallucinations and sleep-wake cycle in PD: a 24-hour continuous poly-somnographic study. Neurology 2002; 59: 1979-81. (Pubitemid 36082814)
32. Marinus J, Visser M, Van Hilten JJ, Lammers GJ, Stiggelbout AM. Assessment of sleep and sleepiness in Parkinson's disease. Sleep 2003a; 26: 1049-54. (Pubitemid 39619769)
33. Marinus J, Visser M, Verwey NA, Verhey FR, Middelkoop HA, Stiggelbout AM, et al. Assessment of cognition in Parkinson's disease. Neurology 2003b; 61: 1222-8. (Pubitemid 37377541)
34. Marsh L, Williams JR, Rocco M, Grill S, Munro C, Dawson TM. Psychiatric comorbidities in patients with Parkinson disease and psychosis. Neurology 2004; 63: 293-300. (Pubitemid 38971129)
35. Matsui H, Udaka F, Tamura A, Oda M, Kubori T, Nishinaka K, et al. Impaired visual acuity as a risk factor for visual hallucinations in Parkinson's disease. J Geriatr Psychiatry Neurol 2006; 19: 36-40. (Pubitemid 43797605)
36. McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005; 65: 1863-72. (Pubitemid 43970103)
37. Meppelink AM, de Jong BM, Renken R, Leenders KL, Cornelissen FW, van Laar T. Impaired visual processing preceding image recognition in Parkinson's disease patients with visual hallucinations. Brain 2009; 132: 2980-93.
38. Meppelink AM, Koerts J, Borg M, Leenders KL, van Laar T. Visual object recognition and attention in Parkinson's disease patients with visual hallucinations. Mov Disord 2008; 23: 1906-12.
39. Merims D, Shabtai H, Korczyn AD, Peretz C, Weizman N, Giladi N. Antiparkinsonian medication is not a risk factor for the development of hallucinations in Parkinson's disease. J Neural Transm 2004; 111: 1447-53. (Pubitemid 39468398)
40. Mishkin M, Ungerleider LG. Contribution of striate inputs to the visuo-spatial functions of parieto-preoccipital cortex in monkeys. Behav Brain Res 1982; 6: 57-77. (Pubitemid 12007158)
41. Miyamoto T, Miyamoto M, Inoue Y, Usui Y, Suzuki K, Hirata K. Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. Neurology 2006; 67: 2236-8. (Pubitemid 46035486)
42. Mosimann UP, Rowan EN, Partington CE, Collerton D, Littlewood E, O'Brien JT, et al. Characteristics of visual hallucinations in Parkinson disease dementia and dementia with lewy bodies. Am J Geriatr Psychiatry 2006; 14: 153-60. (Pubitemid 43227638)
43. Nagano-Saito A, Washimi Y, Arahata Y, Iwai K, Kawatsu S, Ito K, et al. Visual hallucination in Parkinson's disease with FDG PET. Mov Disord 2004; 19: 801-6. (Pubitemid 39139591)
44. Niederhauser S, Mojon DS. Normal isopter position in the peripheral visual field in Goldmann kinetic perimetry. Ophthalmologica 2002; 216: 406-8. (Pubitemid 36131986)
45. Nomura T, Inoue Y, Mitani H, Kawahara R, Miyake M, Nakashima K. Visual hallucinations as REM sleep behavior disorders in patients with Parkinson's disease. Mov Disord 2003; 18: 812-7. (Pubitemid 36939977)
46. Oishi N, Udaka F, Kameyama M, Sawamoto N, Hashikawa K. Fukuyama H Regional cerebral blood flow in Parkinson disease with nonpsychotic visual hallucinations. Neurology 2005; 65: 1708-15.
47. Oka H, Yoshioka M, Onouchi K, Morita M, Mochio S, Suzuki M, et al. Impaired cardiovascular autonomic function in Parkinson's disease with visual hallucinations. Mov Disord 2007; 22: 1510-4. (Pubitemid 47280645)
48. Ozer F, Meral H, Hanoglu L, Ozturk O, Aydemir T, Cetin S, et al. Cognitive impairment patterns in Parkinson's disease with visual hallucinations. J Clin Neurosci 2007; 14: 742-6. (Pubitemid 46907602)
49. Papapetropoulos S, Argyriou AA, Ellul J. Factors associated with drug-induced visual hallucinations in Parkinson's disease. J Neurol 2005; 252: 1223-8. (Pubitemid 41443623)
50. Papapetropoulos S. Regional alpha-synuclein aggregation, dopaminergic dysregulation, and the development of drug-related visual hallucinations in Parkinson's disease. J Neuropsychiatry Clin Neurosci 2006a; 18: 149-57.
51. Papapetropoulos S, McCorquodale DS, Gonzalez J, Jean-Gilles L, Mash DC. Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations. Parkinsonism Relat Disord 2006b; 12: 253-6. (Pubitemid 43737238)
52. Papapetropoulos S, Katzen H, Schrag A, Singer C, Scanlon BK, Nation D, et al. A questionnaire-based (UM-PDHQ) study of hallucinations in Parkinson's disease. BMC Neurol 2008; 8: 21.
53. Parkkinen L, Pirttilä T, Alafuzoff I. Applicability of current staging/categorization of alpha-synuclein pathology and their clinical relevance. Acta Neuropathol 2008; 115: 399-407.
54. Parks RW, Thiyagesh SN, Farrow TF, Ingram L, Wilkinson K, Hunter MD, et al. Performance on the clock drawing task correlates with FMRI response to a visuospatial task in Alzheimer's disease. Int J Neurosci 2010; 120: 335-43.
55. Ramírez-Ruiz B, Junqué C, Martí MJ, Valldeoriola F, Tolosa E. Neuropsychological deficits in Parkinson's disease patients with visual hallucinations. Mov Disord 2006; 21 1483-7.
56. Ramírez-Ruiz B, Martí MJ, Tolosa E, Giménez M, Bargalló N, Valldeoriola F, et al. Cerebral atrophy in Parkinson's disease patients with visual hallucinations. Eur J Neurol, 2007, 14, 750-756.
57. Ramírez-Ruiz B, Martí MJ, Tolosa E, Falcón C, Bargalló N, Valldeoriola F, et al Brain response to complex visual stimuli in Parkinson's patients with hallucinations: a functional magnetic resonance imaging study. Mov Disord, 2008, 23, 2335-2343.
58. Riddoch JM, Humphreys GW. Birmingham object recognition battery. Hove, UK: Psychology Press; 1993.
59. Sanchez-Ramos JR, Ortoll R, Paulson GW. Visual hallucinations associated with Parkinson disease. Arch Neurol 1996; 53: 1265-8. (Pubitemid 26425072)
60. Schwab JJ, Bialow MR, Clemmons RS, Holzer CE. Hamilton rating scale for depression with medical in-patients. Br J Psychiatry 1967; 113: 83-8.
61. Sockeel P, Dujardin K, Devos D, Denève C, Destée A, Defebvre L. The Lille apathy rating scale (LARS), a new instrument for detecting and quantifying apathy: validation in Parkinson's disease. J Neurol Neurosurg Psychiatry 2006; 77: 579-84. (Pubitemid 43844578)
62. Sprague JB, Stock LA, Connett J, Bromberg J. Study of chart designs and optotypes for preschool vision screening. Comparability of chart designs. J Pediatr Ophthalmol Strabismus 1989; 26: 189-97. (Pubitemid 19179774)
63. Visser M, Marinus J, Stiggelbout AM, Van Hilten JJ. Assessment of auto-nomic dysfunction in Parkinson's disease: the SCOPA-AUT. Mov Disord 2004; 19: 1306-12. (Pubitemid 39534547)
64. Whitehead DL, Davies AD, Playfer JR, Turnbull CJ. Circadian rest-activity rhythm is altered in Parkinson's disease patients with hallucinations. Mov Disord 2008; 23: 1137-45.
65. Williams DR, Lees AJ. Visual hallucinations in the diagnosis of idiopathic Parkinson's disease: a retrospective autopsy study. Lancet Neurol 2005; 4: 605-10. (Pubitemid 41317294)