Muscle strength and sedative load in community-dwelling people aged 75 years and older: A population-based study

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 66 A, Issue 12, 2011, Pages 1384-1392

  Taipale, Heidi T ^a   Bell, J Simon ^a,b   Gnjidic, Danijela ^c,d,e   Sulkava, Raimo ^a,f   Hartikainen, Sirpa ^a,g  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^c ROYAL NORTH SHORE HOSPITAL   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e ANZAC Research Institute   (Australia)

^f KUOPIO UNIVERSITY HOSPITAL   (Finland)

^g Leppavirta Health Centre   (Finland)

Author keywords

Aged; Drug utilization; Hypnotics and sedatives; Muscle strength

Indexed keywords

HYPNOTIC SEDATIVE AGENT;

AGED; AGING; ARTICLE; DEMOGRAPHY; DRUG EFFECT; EPIDEMIOLOGY; FEMALE; FINLAND; HUMAN; MALE; MUSCLE STRENGTH; MUSCLE WEAKNESS; PATHOPHYSIOLOGY; PHYSIOLOGY; SOCIOECONOMICS;

AGED; AGED, 80 AND OVER; AGING; FEMALE; FINLAND; HUMANS; HYPNOTICS AND SEDATIVES; MALE; MUSCLE STRENGTH; MUSCLE WEAKNESS; RESIDENCE CHARACTERISTICS; SAMPLING STUDIES; SOCIOECONOMIC FACTORS;

EID: 81055144354     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glr170     Document Type: Article

References (50)

1. Penninx BWJH, Ferrucci L, Leveille SG, Rantanen T, Pahor M, Guralnik JM. Lower extremity performance in nondisabled older persons as a predictor of subsequent hospitalization. J Gerontol Med Sci. 2000;55A:M691-M697. (Pubitemid 32010316)
2. Hairi NN, Cumming RG, Naganathan V, et al. Loss of muscle strength, mass (sarcopenia), and quality (specific force) and its relationship with functional limitation and physical disability: the Concord Health and Ageing in Men Project. J Am Geriatr Soc. 2010;58:2055-2062.
3. Newman AB, Kupelian V, Visser M, et al. Strength, but not muscle mass, is associated with mortality in Health, Aging and Body Composition Study Cohort. J Gerontol A Biol Sci Med Sci. 2006;61A:72-77. (Pubitemid 43227803)
4. Cooper R, Kuh D, Hardy R. Objectively measured physical capability levels and mortality: systematic review and meta-analysis. BMJ. 2010;341:c4467.
5. Moreland JD, Richardson JA, Goldsmith CH, Clase CM. Muscle weakness and falls in older adults: a systematic review and meta-analysis. J Am Geriatr Soc. 2004;52:1121-1129. (Pubitemid 38869071)
6. Lord SR, Anstey KJ, Williams P, Ward JA. Psychoactive medication use, sensori-motor function and falls in older women. Br J Clin Pharmacol. 1995;39:227-234.
7. Cutson TM, Gray SL, Hughes MA, Carson SW, Hanlon JT. Effect of a single dose of diazepam on balance measures in older people. J Am Geriatr Soc. 1997;45:435-440. (Pubitemid 27169218)
8. Clark DJ, Patten C, Reid KF, Carabello RJ, Phillips EM, Fielding RA. Muscle performance and physical function are associated with voluntary rate of neuromuscular activation in older adults. J Gerontol A Biol Sci Med Sci. 2011;66:115-121.
9. Clark BC, Taylor JL, Hoffman RL, Dearth DJ, Thomas JS. Cast immobilization increases long-interval intracortical inhibition. Muscle Nerve. 2010;42:363-372.
10. Cao YJ, Mager DE, Simonsick EM, et al. Physical and cognitive performance and burden of anticholinergics, sedatives, and ACE inhibitors in older women. Clin Pharmacol Ther. 2008;83:422-429. (Pubitemid 351272629)
11. Gnjidic D, Cumming RG, Le Couteur DG, et al. Drug burden index and physical function in older Australian men. Br J Clin Pharmacol. 2009;68:97-105.
12. Bourin M, Briley M. Sedation, an unpleasant, undesirable and potentially dangerous side-effect of many psychotropic drugs. Hum Psychopharmacol. 2004;19:135-139. (Pubitemid 38332062)
13. Bowie MW, Slattum PW. Pharmacodynamics in older adults: a review. Am J Geriatr Pharmacother. 2007;5:263-303. (Pubitemid 350048507)
14. Linjakumpu T, Hartikainen S, Klaukka T, Koponen H, Kivelä SL, Isoaho R. Psychotropics among the home-dwelling elderly-increasing trends. Int J Geriatr Psychiatry. 2002;17:874-883.
15. Linjakumpu TA, Hartikainen SA, Klaukka TJ, et al. Sedative drug use in the home-dwelling elderly. Ann Pharmacother. 2004;38:2017-2022. (Pubitemid 40169368)
16. Aparasu RR, Mort JR, Brandt H. Psychotropic prescription use by community-dwelling elderly in the United States. J Am Geriatr Soc. 2003;51:671-677. (Pubitemid 36541432)
17. Weston AL, Weinstein AM, Barton C, Yaffe K. Potentially inappropriate medication use in older adults with mild cognitive impairment. J Gerontol A Biol Sci Med Sci. 2010;65A:318-321.
18. Taipale HT, Bell JS, Soini H, Pitkälä KH. Sedative load and mortality among residents of long-term care facilities. A prospective cohort study. Drugs Aging. 2009;26:1-11.
19. Taipale HT, Hartikainen S, Bell JS. A comparison of four methods to quantify the cumulative effect of taking multiple drugs with sedative properties. Am J Geriatr Pharmacother. 2010;8:460-471.
20. Linjakumpu T, Hartikainen S, Klaukka T, Koponen H, Kivelä SL, Isoaho R. A model to classify the sedative load of drugs. Int J Geriatr Psychiatry. 2003;18:542-544. (Pubitemid 36763660)
21. Lihavainen K, Sipilä S, Rantanen T, Sihvonen S, Sulkava R, Hartikainen S. Contribution of musculoskeletal pain to postural balance in community-dwelling people aged 75 years and older. J Gerontol A Biol Sci Med Sci. 2010;65:990-996.
22. Rigler SK, Perera S, Jachna C, Shireman TI, Eng M. Comparison of the association between disease burden and inappropriate medication use across three cohorts of older adults. Am J Geriatr Pharmacother. 2004;2:239-247. (Pubitemid 40378778)
23. Van Rensbergen G, Nawrot T. Medical conditions of nursing home admissions. BMC Geriatr. 2010;10:46.
24. WHO Collaborating Centre for Drug Statistics Methodology. The Anatomical Therapeutic chemical classification system 2010 [online]. http://www.whocc.no/ atcddd/. Accessed November 24, 2010.
25. Crum RM, Anthony JC, Bassett SS, Folstein MF. Population-based norms for the Mini-Mental State Examination by age and education level. JAMA. 1993;269:2386-2391. (Pubitemid 23129378)
26. Dahl A, Berg S, Nilsson SE. Identification of dementia in epidemiological research: a study on the usefulness of various data sources. Aging Clin Exp Res. 2007;19:381-390.
27. Groll DL, To T, Bombardier C, Wright JG. The development of a comorbidity index with physical function as the outcome. J Clin Epidemiol. 2005;58:595-602. (Pubitemid 40692725)
28. Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res. 1982-1983;17:37-49. (Pubitemid 13123113)
29. Furu K, Wettermark B, Andersson M, Martikainen JE, Almasdottir AB, Sorensen HT. The Nordic countries as a cohort for pharmacoepidemiological research. Basic Clin Pharmacol Toxicol. 2010;106:86-94.
30. Grimby G. Physical activity and muscle training in the elderly. Acta Med Scand Suppl. 1986;711:233-237. (Pubitemid 16008744)
31. Guralnik JM, Simonsick EM, Ferrucci L, et al. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994;49:M85-M94. (Pubitemid 24100267)
32. Cesari M, Kritchevsky SB, Newman AB, et al. Added value of physical performance measures is predicting adverse health-related events: results from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2009;57:251-259.
33. Ashfield TA, Syddall HE, Martin HJ, Dennison EM, Cooper C, Aihie Sayer A. Grip strength and cardiovascular drug use in older people: findings from the Hertfordshire Cohort Study. Age Ageing. 2010;39:185-191.
34. Cooper R, Kuh D, Cooper C, et al. Objective measures of physical capability and subsequent health: a systematic review. Age Ageing. 2011;40:14-23.
35. Maki BE, McIlroy WE. Control of rapid limb movements for balance recovery: age-related changes and implications for fall prevention. Age Ageing. 2006;35(S2):ii12-ii18. (Pubitemid 44687503)
36. Turnheim K. When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly. Exp Gerontol. 2003;38:843-853. (Pubitemid 36952666)
37. McLachlan AJ, Hilmer SN, Le Couteur DG. Variability in response to medicines in older people: phenotypic and genotypic factors. Clin Pharmacol Ther. 2009;85:431-433.
38. Davidoff RA. Antispasticity drugs: mechanisms of action. Ann Neurol. 1985;17:107-116. (Pubitemid 15170430)
39. Young-McCaughan S, Miaskowski C. Definition of and mechanism for opioid-induced sedation. Pain Manag Nurs. 2001;2:84-97. (Pubitemid 33077261)
40. Buffett-Jerrott SE, Stewart SH. Cognitive and sedative effects of benzodiazepine use. Curr Pharm Des. 2002;8:45-58. (Pubitemid 34449902)
41. McGinley M, Hoffman RL, Russ DW, Thomas JS, Clark BC. Older adults exhibit more intracortical inhibition and less intracortical facilitation than young adults. Exp Gerontol. 2010;45:671-678.
42. Atkinson HH, Rapp SR, Williamson JD, et al. The relationship between cognitive function and physical performance in older women: results from the Women's Health Initiative Memory Study. J Gerontol A Biol Sci Med Sci. 2010;65A:300-306.
43. Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981;30:239-245. (Pubitemid 12149145)
44. Gray SL, LaCroix AZ, Hanlon JT, et al. Benzodiazepine use and physical disability in community-dwelling older adults. J Am Geriatr Soc. 2006;54:224-230.
45. McClelland GR. Body sway and the effects of psychoactive drugs-a review. Hum Psychopharmacol. 1989;4:3-14. (Pubitemid 19090733)
46. Hartikainen S, Lönnroos E, Louhivuori K. Medication as a risk factor for falls: critical systematic review. J Gerontol A Biol Sci Med Sci. 2007;62:1172-1181. (Pubitemid 47599431)
47. Sarkisian CA, Liu H, Gutierrez PR, Seeley DG, Cummings SR, Mangione CM. Modifiable risk factors predict functional decline among older women: a prospectively validated clinical prediction tool. The Study of Osteoporotic Fractures Research Group. J Am Geriatr Soc. 2000;48:170-178. (Pubitemid 30106521)
48. Lindley RI. Drug trials for older people. J Gerontol A Biol Sci Med Sci.[Epub ahead of print].
49. Hilmer SN, Gnjidic D, Abernethy DR. Pharmacoepidemiology in the postmarketing assessment of the safety and efficacy of drugs in older adults. J Gerontol A Biol Sci Med Sci. 2011; 1-8. [Epub ahead of print].
50. LaCroix AZ, Guralnik JM, Berkman LF, Wallace RB, Satterfield S. Maintaining mobility in late life. II. Smoking, alcohol consumption, physical activity, and body mass index. Am J Epidemiol. 1993;137:858-869. (Pubitemid 23149664)