The role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6 -174GC, IL-8 -251AT and MCP-1 -2518AG in the risk of venous thromboembolism: A case-control study

Thrombosis Research

Volumn 128, Issue 3, 2011, Pages 216-220

  Matos, Marinez F ^a   Lourenço, Dayse M ^a   Orikaza, Cristina M ^a   Bajerl, João A H ^a   Noguti, Maria A E ^a   Morelli, Vânia M ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Interleukin; Polymorphism; Risk factor; Venous thromboembolism

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; SEX HORMONE;

ADULT; AGE; ANTICOAGULANT THERAPY; ARTICLE; BLOOD SAMPLING; BODY MASS; CASE CONTROL STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; ETHNICITY; FEMALE; GENETIC RISK; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; RISK ASSESSMENT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; VENOUS THROMBOEMBOLISM;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHEMOKINE CCL2; CYTOKINES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-6; INTERLEUKIN-8; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; VENOUS THROMBOSIS; YOUNG ADULT;

EID: 80955178377     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.04.016     Document Type: Article

References (30)

1. M. Levi, and T. van der Poll Inflammation and coagulation Crit Care Med 38 2010 S26 S34
2. C. Gabay, and I. Kushner Acute-phase proteins and other systemic responses to inflammation N Engl J Med 340 1999 448 454 (Pubitemid 29084777)
3. B.E. van Aken, M. den Heijer, G.M. Bos, S. van Deventer, and P.H. Reitsma Recurrent venous thrombosis and markers of inflammation Thromb Haemost 83 2000 536 539 (Pubitemid 30201126)
4. B.E. van Aken, P.H. Reitsma, and F.R. Rosendaal Interleukin 8 and venous thrombosis: evidence for a role of inflammation in thrombosis Br J Haematol 116 2002 173 177 (Pubitemid 34122078)
5. P.H. Reitsma, and F.R. Rosendaal Activation of innate immunity in patients with venous thrombosis: the Leiden Thrombophilia Study J Thromb Haemost 2 2004 619 622 (Pubitemid 40185686)
6. R. Vormittag, K. Hsieh, A. Kaider, E. Minar, C. Bialonczyk, and M. Hirschl Interleukin-6 and interleukin-6 promoter polymorphism (- 174) G > C in patients with spontaneous venous thromboembolism Thromb Haemost 95 2006 802 806
7. S.C. Christiansen, I.A. Naess, S.C. Cannegieter, J. Hammerstrøm, F.R. Rosendaal, and P.H. Reitsma Inflammatory cytokines as risk factors for a first venous thrombosis: a prospective population-based study PLoS Med 3 2006 e334
8. P. Jerrard-Dunne, M. Sitzer, P. Risley, D.A. Steckel, A. Buehler, and S. von Kegler Interleukin-6 promoter polymorphism modulates the effects of heavy alcohol consumption on early carotid artery atherosclerosis: the Carotid Atherosclerosis Progression Study (CAPS) Stroke 34 2003 402 407 (Pubitemid 36206338)
9. J. Bidwell, L. Keen, G. Gallagher, R. Kimberly, T. Huizinga, and M.F. McDermott Cytokine gene polymorphism in human disease: on-line databases Genes Immun 1 1999 3 19 (Pubitemid 129622776)
10. D. Fishman, G. Faulds, R. Jeffery, V. Mohamed-Ali, J.S. Yudkin, and S. Humphries The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis J Clin Invest 102 1998 1369 1376 (Pubitemid 28467565)
11. J. Hull, A. Thomson, and D. Kwiatkowski Association of respiratory syncytial virus bronchiolitis with the interleukin 8 gene region in UK families Thorax 55 2000 1023 1027
12. B.H. Rovin, L. Lu, and R. Saxena A novel polymorphism in the MCP-1 gene regulatory region that influences MCP-1 expression Biochem Biophys Res Commun 259 1999 344 348 (Pubitemid 29281234)
13. F. Pieroni, D.M. Lourenço, V.M. Morelli, F.H. Maffei, M.A. Zago, and R.F. Franco Cytokine gene variants and venous thrombotic risk in the BRATROS (BRAZILIAN THROMBOSIS STUDY) Thromb Res 120 2007 221 229 (Pubitemid 46754420)
14. M.M. Beckers, H.J. Ruven, F.J. Haas, P.A. Doevendans, H. Ten Cate, and M.H. Prins Single nucleotide polymorphisms in inflammation-related genes are associated with venous thromboembolism Eur J Intern Med 21 2010 289 292
15. M.A. Zago, and F.F. Costa Hereditary haemoglobin disorders in Brazil Trans R Soc Trop Med Hyg 79 1985 385 388 (Pubitemid 15062135)
16. C. Zheng, D.R. Huang, S. Bergenbrant, A. Sundblad, A. Osterborg, and M. Bjorkholm Interleukin 6, tumour necrosis factor alpha, interleukin 1beta and interleukin 1 receptor antagonist promoter or coding gene polymorphisms in multiple myeloma Br J Haematol 109 2000 39 45 (Pubitemid 30340577)
17. A. Heinzmann, I. Ahlert, T. Kurz, R. Berner, and K.A. Deichmann Association study suggests opposite effects of polymorphisms within IL8 on bronchial asthma and respiratory syncytial virus bronchiolitis J Allergy Clin Immunol 114 2004 671 676 (Pubitemid 39194946)
18. F.J. Neumann, I. Ott, N. Marx, T. Luther, S. Kenngott, and M. Gawaz Effect of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity Arterioscler Thromb Vasc Biol 17 1997 3399 3405 (Pubitemid 28028548)
19. T. van der Poll, M. Levi, C.E. Hack, H. ten Cate, S.J. van Deventer, and A.J. Eerenberg Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees J Exp Med 179 1994 1253 1259 (Pubitemid 24091784)
20. P.M. Ridker, M. Cushman, M.J. Stampfer, R.P. Tracy, and C.H. Hennekens Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men N Engl J Med 336 1997 973 979 (Pubitemid 27152782)
21. A.W. Tsai, M. Cushman, W.D. Rosamond, S.R. Heckbert, R.P. Tracy, and N. Aleksic Coagulation factors, inflammation markers, and venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE) Am J Med 113 2002 636 642 (Pubitemid 36015799)
22. B.K. Mahmoodi, R.T. Gansevoort, N.J. Veeger, A.G. Matthews, G. Navis, and H.L. Hillege Microalbuminuria and risk of venous thromboembolism JAMA 301 2009 1790 1797
23. A.R. Folsom, P.L. Lutsey, B.C. Astor, and M. Cushman C-reactive protein and venous thromboembolism. A prospective investigation in the ARIC cohort Thromb Haemost 102 2009 615 619
24. P. Quist-Paulsen, I.A. Naess, S.C. Cannegieter, P.R. Romundstad, S.C. Christiansen, and F.R. Rosendaal Arterial cardiovascular risk factors and venous thrombosis: results from a population-based, prospective study (the HUNT 2) Haematologica 95 2010 119 125
25. J. Zacho, A. Tybjaerg-Hansen, and B.G. Nordestgaard C-reactive protein and risk of venous thromboembolism in the general population Arterioscler Thromb Vasc Biol 30 2010 1672 1678
26. R.J. Glynn, E. Danielson, F.A. Fonseca, J. Genest, A.M. Gotto Jr., and J.J. Kastelein A randomized trial of rosuvastatin in the prevention of venous thromboembolism N Engl J Med 360 2009 1851 1861
27. A. Squizzato, M. Galli, E. Romualdi, F. Dentali, P.W. Kamphuisen, and L. Guasti Statins, fibrates, and venous thromboembolism: a meta-analysis Eur Heart J 31 2010 1248 1256
28. A.W. Tsai, M. Cushman, W.D. Rosamond, S.R. Heckbert, J.F. Polak, and A.R. Folsom Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiology Arch Intern Med 162 2002 1182 1189 (Pubitemid 34522408)
29. A. Undas, M. Celińska-Löwenhoff, M. Kaczor, and J. Musial New nonlipid effects of statins and their clinical relevance in cardiovascular disease Thromb Haemost 91 2004 1065 1077 (Pubitemid 38821261)
30. D. Kelberman, E. Hawe, L.A. Luong, V. Mohamed-Ali, P. Lundman, and P. Tornvall Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe. The HIFMECH Study Thromb Haemost 92 2004 1122 1128 (Pubitemid 39545538)