New insights in naevogenesis: Number, distribution and dermoscopic patterns of naevi in the elderly

Australasian Journal of Dermatology

Volumn 52, Issue 4, 2011, Pages 254-258

  Piliouras, Peter ^a,c   Gilmore, Stephen ^a,b   Wurm, Elisabeth M ^a   Soyer, H Peter ^a,b   Zalaudek, Iris ^d,e  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b GREENSLOPES PRIVATE HOSPITAL   (Australia)

^c JAMES COOK UNIVERSITY   (Australia)

^d MEDICAL UNIVERSITY OF GRAZ   (Austria)

^e S MARIA NUOVA HOSPITAL   (Italy)

Author keywords

dermoscopy; melanocytic naevi; naevus types

Indexed keywords

ADULT; AGED; ARTICLE; COHORT ANALYSIS; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; FEMALE; GROUPS BY AGE AND SEX; HEAD; HUMAN; LIMB; MALE; MORPHOLOGY; NECK; NEVUS; TRUNK;

AGE FACTORS; AGED; AGED, 80 AND OVER; DERMOSCOPY; EXTREMITIES; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; MIDDLE AGED; NEVUS, PIGMENTED; SKIN NEOPLASMS; TORSO;

EID: 80955158660     PISSN: 00048380     EISSN: 14400960     Source Type: Journal    
DOI: 10.1111/j.1440-0960.2011.00794.x     Document Type: Article

References (27)

1. Tucker MA, Fraser MC, Goldstein AM, et al,. A natural history of melanomas and dysplastic nevi: an atlas of lesions in melanoma-prone families. Cancer 2002; 12: 3192-209. (Pubitemid 34670503)
2. Halpern AC, Guerry D 4th, Elder DE, et al,. Natural history of dysplastic nevi. J. Am. Acad. Dermatol. 1993; 29: 51-7. (Pubitemid 23197196)
3. Kincannon J, Boutzale C,. The physiology of pigmented nevi. Pediatrics 1999; 104: 1042-5. (Pubitemid 29463550)
4. Zalaudek I, Docimo G, Argenziano G,. Using dermoscopic criteria and patient-related factors for the management of pigmented melanocytic nevi. Arch. Dermatol. 2009; 145: 816-26.
5. Hofmann-Wellenhof R, Blum A, Wolf IH, et al,. Dermoscopic classification of atypical melanocytic nevi (Clark's nevi). Arch. Dermatol. 2001; 137: 1575-80. (Pubitemid 34000905)
6. Zalaudek I, Grinschgl S, Argenziano G, et al,. Age-related prevalence of dermoscopy patterns in acquired melanocytic naevi. Br. J. Dermatol. 2006; 154: 299-304. (Pubitemid 43382701)
7. Argenziano G, Zalaudek I, Ferrara G, et al,. Proposal of a new classification system for melanocytic naevi. Br. J. Dermatol. 2007; 157: 217-27. (Pubitemid 47083835)
8. Ackerman A, Magana-Garcia M,. Naming acquired melanocytic nevi. Unna's, Miecher's, Spitz's, Clark's. Am. J. Dermatopathol. 1990; 12: 193-209. (Pubitemid 20122155)
9. Worret WI, Burgdorf WH,. Which direction do nevus cells move? Abtropfung reexamined. Am. J. Dermatopathol. 1998; 20: 135-9. (Pubitemid 28164960)
10. Martinka M, Bruecks AK, Trotter MJ,. Histologic spectrum of melanocytic nevi removed from patients >60 years of age. J. Cutan. Med. Surg. 2007; 11: 168-73.
11. Westhafer J, Gildea J, Klepeiss S, et al,. Age distribution of biopsied junctional nevi. J. Am. Acad. Dermatol. 2007; 56: 825-7. (Pubitemid 46561007)
12. Zalaudek I, Hofmann-Wellenhof R, Kittler H, et al,. A dual concept of nevogenesis: theoretical considerations based on dermoscopic features of melanocytic nevi. J. Dtsch. Dermatol. Ges. 2007; 5: 985-92. (Pubitemid 350049392)
13. Fitzpatrick TB,. Soleil et peau. J. Med. Esthet. 1975; 2: 33-4.
14. Zalaudek I, Catricalà C, Moscarella E, et al,. What dermoscopy tells us about nevogenesis. J. Dermatol. 2011; 38: 16-24.
15. Witt C, Krengel S,. Clinical and epidemiological aspects of subtypes of melanocytic nevi (Flat nevi, Miescher nevi, Unna nevi). Dermatol. Online J. 2010; 16: 1. Available from URL: (Accessed 25 November 2010.)
16. Maize JC, Foster G,. Age-related changes in melanocytic nevi. Clin. Exp. Dermatol. 1979; 4: 49-58.
17. Harrison SL, Buettner PG, MacLennan R,. Body-site distribution of melanocytic nevi in young Australian children. Arch. Dermatol. 1999; 135: 47-52. (Pubitemid 29069516)
18. Chanchien L, Dusza SW, Agero AL, et al,. Age-and site-specific variation in the dermoscopic patterns of congenital melanocytic nevi: an aid to accurate classification and assessment of melanocytic nevi. Arch. Dermatol. 2007; 143: 1007-14. (Pubitemid 47296077)
19. Seidenari S, Pellacani G, Martella A, et al,. Instrument-, age- and site-dependent variations of dermoscopic patterns of congenital melanocytic naevi: a multicentre study. Br. J. Dermatol. 2006; 155: 56-61. (Pubitemid 43876393)
20. Zalaudek I, Guelly C, Pellacani G, et al,. The dermoscopical and histopathological patterns of nevi correlate with the frequency of BRAF mutations. J. Invest. Dermatol. 2010; 131: 542-5.
21. Ichii-Nakato N, Takata M, Takayanagi S, et al,. High frequency of BRAFV600E mutation in acquired nevi and small congenital nevi, but low frequency of mutation in medium-sized congenital nevi. J. Invest. Dermatol. 2006; 126: 2111-8.
22. Bauer J, Curtin JA, Pinkel D, et al,. Congenital melanocytic nevi frequently harbor NRAS mutations but no BRAF mutations. J. Invest. Dermatol. 2007; 127: 179-82. (Pubitemid 46005676)
23. Hafner C, Stoehr R, van Oers JM, et al,. The absence of BRAF, FGFR3, and PIK3CA mutations differentiates lentigo simplex from melanocytic nevus and solar lentigo. J. Invest. Dermatol. 2009; 129: 2730-5.
24. Kaddu S, Smolle J, Zenahlik P, et al,. Melanoma with benign melanocytic naevus components: reappraisal of clinicopathological features and prognosis. Melanoma Res. 2002; 12: 271-8. (Pubitemid 34666818)
25. Purdue MP, From L, Armstrong BK, et al,. Etiologic and other factors predicting nevus-associated cutaneous malignant melanoma. Cancer Epidemiol. Biomarkers. Prev. 2005; 14: 2015-22. (Pubitemid 41161217)
26. Lasithiotakis KG, Petrakis IE, Garbe C,. Cutaneous melanoma in the elderly: epidemiology, prognosis and treatment. Melanoma Res. 2010; 20: 163-70.
27. Tsao H, Bevona C, Goggins W, et al,. The transformation rate of moles (melanocytic nevi) into cutaneous melanoma: a population-based estimate. Arch. Dermatol. 2003; 139: 282-8. (Pubitemid 36330574)