Change in testosterone concentrations over time is a better predictor than the actual concentrations for symptoms of late onset hypogonadism

Aging Male

Volumn 14, Issue 4, 2011, Pages 249-256

  Spetz Holm, Anna Clara E ^a,b   Fredrikson, Mats G ^a,b   Theodorsson, Elvar ^a,b   Palmefors, Lennart G ^a,b   Karlsson, Per S ^a,b   Joborn, Charlotte ^a,b   Hammar, Mats L ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b Centre of Surgery and Oncology   (Sweden)

Author keywords

androgens; andrology; climacteric; Men; questionnaires; testosterone

Indexed keywords

ACETYLSALICYLIC ACID; ALBUMIN; ANALGESIC AGENT; ANTIALLERGIC AGENT; ANTIASTHMATIC AGENT; ANTICONVULSIVE AGENT; ANTIHYPERTENSIVE AGENT; ANTILIPEMIC AGENT; BICALUTAMIDE; CARDIOVASCULAR AGENT; GASTROINTESTINAL AGENT; INSULIN; METHOTREXATE; ORAL ANTIDIABETIC AGENT; SEDATIVE AGENT; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; SEROTONIN UPTAKE INHIBITOR; SEX HORMONE; TESTOSTERONE; WARFARIN;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ALLERGY; ANDROGEN DECLINE IN AGING MALES QUESTIONNAIRE; ARTICLE; ASTHMA; BIOAVAILABILITY; BODY HEIGHT; CARDIOVASCULAR DISEASE; CONSTIPATION; CROSS-SECTIONAL STUDY; DEMOGRAPHY; DRUG USE; ENDURANCE; EPILEPSY; EXERCISE; HOT FLUSH; HUMAN; HYPERTENSION; HYPOGONADISM; LATE ONSET HYPOGONADISM; LIBIDO; LONGITUDINAL STUDY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MUSCLE STRENGTH; MUSCULOSKELETAL PAIN; PENIS ERECTION; PHYSICAL PERFORMANCE; PREDICTIVE VALUE; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; SKIN FRAGILITY; SYMPTOMATOLOGY; TESTOSTERONE BLOOD LEVEL;

AGE OF ONSET; AGED; AGED, 80 AND OVER; AGING; HUMANS; HYPOGONADISM; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PENILE ERECTION; QUESTIONNAIRES; TESTOSTERONE;

EID: 80955158102     PISSN: 13685538     EISSN: 14730790     Source Type: Journal    
DOI: 10.3109/13685538.2011.582527     Document Type: Article

References (22)

1. Wang C, Nieschlag E, Swerdloff R, Behre HM, Hellstrom WJ, Gooren LJ, Kaufman JF, Legros JJ, Lunenfeld B, Morales A, et al. ISA, ISSAM, EUA, EAA, and ASA recommendations: investigation, treatment, and monitoring of late-onset hypogonadism in males. Aging Male 2009;12:5-12.
2. Morales A, Heaton JP, Carson CC III. Andropause: a misnomer for a true clinical entity. J Urol 2000;163:705-712. (Pubitemid 30091601)
3. Lunenfeld B, Nieschlag E. Testosterone therapy in the aging male. Aging Male 2007;10:139-153. (Pubitemid 47265837)
4. Moncada I. Testosterone and men's quality of life. Aging Male 2006;9:189-193.
5. Morley JE. Should frailty be treated with testosterone? Aging Male 2011;14:1-3.
6. Nahoul K, Roger M. Age-related decline of plasma bioavailable testosterone in adult men. J Steroid Biochem 1990; 35:293-299. (Pubitemid 20067775)
7. Gray A, Feldman HA, McKinlay JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts male aging study. J Clin Endocrinol Metab 1991;73:1016-1025. (Pubitemid 21901140)
8. Spetz AC, Palmefors L, Skobe S, Strömstedt M, Fredriksson M, Theodorsson E, Hammar ML. Testosterone correlated to symptoms of 'Partial Androgen Deficiency in Aging Men' (PADAM) in a Swedish elderly population. Menopause 2007; 14:999-1005. (Pubitemid 350098659)
9. Spetz AC, Fredrikson MG, Hammar ML. Hot flushes in a male population aged 55, 65, and 75 years, living in the community of Linkoping, Sweden. Menopause 2003;10:81-87. (Pubitemid 36706326)
10. Hanus M, Matouskova M, Starka L, Hill M. Hormonal homeostasis in a group of 216 Czech males and correlation with responses to a questionnaire of the University of St Louis. Aging Male 2006;9:103-110. (Pubitemid 44266882)
11. T'Sjoen G, Goemaere S, De Meyere M, Kaufman J. Perception of males aging symptoms, health and well-being in elderly community-dwelling men is not related to circulating androgen levels. Psychoneuroendocrinology 2004;29:201-214. (Pubitemid 37357179)
12. Gladh M, Rahgozar M, Hammar M, Fredriksson M, Spetz A-C. Prevalence of symptoms possibly related to PADAM, in a Swedish population aged 55, 65 and 75 years. Maturitas 2005; 50:161-166. (Pubitemid 40269899)
13. Morley JE. Sex hormones and diabetes. Diabetes Metab Rev 1998;6:6-15. (Pubitemid 28284584)
14. Morley JE, Charlton E, Patrick P, Kaiser FE, Cadeau P, McCready D, Perry HM III. Validation of a screening questionnaire for androgen deficiency in aging males. Metabolism 2000;49:1239-1242.
15. Vermeulen A. The physical state of testosterone in plasma. In: James VHT. et al., editors. The endocrine function of the human testes. New York: Academic Press; 1973. pp. 157-170.
16. Hammar M, Berg G, Fåhraeus L, Larsson-Cohn U. Climacteric symptoms in an unselected sample of Swedish women. Maturitas 1984;6:345-350. (Pubitemid 15138671)
17. Karling P, Hammar M, Varenhorst E. Prevalence and duration of hot flushes after surgical or medical castration in men with prostatic carcinoma. J Urol 1994;152:1170-1173. (Pubitemid 24283460)
18. McKinlay JB, Travison TG, Araujo AB, Kupelian V. Male menopause - time for a decent burial? [Editorial] Menopause 2007;14:973-975. (Pubitemid 350098654)
19. Sartorius GA, Nieschlag E. Paternal age and reproduction. Hum Reprod Update 2010;16:65-79.
20. Gould DC, Petty R, Jacobs HS. For and against: The male menopause-does it exist? BMJ 2000;320:858-861.
21. Schow DA, Redmon B, Pryor JL. Male menopause. How to define it, how to treat it. Postgrad Med 1997;101:62-64, 67-68, 71-74.
22. Morley JE. The diagnosis of late life hypogonadism. The Aging Male 2007;10:217-220. (Pubitemid 350146726)