Effects of Dextromethorphan on reducing methadone dosage in opium addicts undergoing methadone maintenance therapy: A double blind randomized clinical trial

Journal of Research in Medical Sciences

Volumn 16, Issue 10, 2011, Pages 1354-1360

  Salehi, Mehrdad ^a   Zargar, Ali ^b   Ramezani, Mohammad Arash ^a  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b NONE

Author keywords

Addiction; Dextromethorphan; Maintenance therapy; Methadone; Opiate dependence

Indexed keywords

DEXTROMETHORPHAN; METHADONE; OPIATE; PLACEBO;

ADULT; AGITATION; ANXIETY DISORDER; ARTICLE; COLD SENSATION; CONTROLLED STUDY; DEPRESSION; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; FOLLOW UP; HEART PALPITATION; HUMAN; INSOMNIA; IRRITABILITY; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; OPIATE ADDICTION; PAIN; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RIGIDITY; SCORING SYSTEM; SIDE EFFECT; TENESMUS; WITHDRAWAL SYNDROME; YAWNING;

EID: 80955149458     PISSN: 17351995     EISSN: 17357136     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Trafton JA, Ramani A. Methadone: a new old drug with promises and pitfalls. Curr Pain Headache Rep 2009; 13(1): 24-30.
2. Faggiano F, Vigna-Taglianti F, Versino E, Lemma P. Methadone maintenance at different dosages for opioid dependence. Cochrane Database Syst Rev 2003; (3): CD002208.
3. Bakker A, Fazey C. Methadone tolerance testing in drug misusers. BMJ 2006; 333(7577): 1056-9.
4. Kosten TR, George TP. The neurobiology of opioid dependence: implications for treatment. Sci Pract Perspect 2002; 1(1): 13-20.
5. Mendez IA, Trujillo KA. NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats. Psychopharmacology (Berl) 2008; 196(3): 497-509.
6. Hewitt DJ. The use of NMDA-receptor antagonists in the treatment of chronic pain. Clin J Pain 2000; 16(2 Suppl): S73-S79.
7. Gustin SM, Schwarz A, Birbaumer N, Sines N, Schmidt AC, Veit R, et al. NMDA-receptor antagonist and morphine decrease CRPS-pain and cerebral pain representation. Pain 2010; 151(1): 69-76.
8. Fischer BD, Carrigan KA, Dykstra LA. Effects of N-methyl-D-aspartate receptor antagonists on acute morphineinduced and l-methadone-induced antinociception in mice. J Pain 2005; 6(7): 425-33.
9. Allen RM, Granger AL, Dykstra LA. Dextromethorphan potentiates the antinociceptive effects of morphine and the delta-opioid agonist SNC80 in squirrel monkeys. J Pharmacol Exp Ther 2002; 300(2): 435-41.
10. Cornish JW, Herman BH, Ehrman RN, Robbins SJ, Childress AR, Bead V, et al. A randomized, double-blind, placebo-controlled safety study of high-dose dextromethorphan in methadone maintained male inpatients. Drug Alcohol Depend 2002; 67(2): 177-83.
11. Nedjat S, Holakouie NK, Mohammad K, Majdzadeh R, Montazeri A. Quality of life among an Iranian general population sample using the World Health Organization's quality of life instrument (WHOQOL-BREF). Int J Public Health 2011; 56(1): 55-61.
12. Handelsman L, Cochrane KJ, Aronson MJ, Ness R, Rubinstein KJ, Kanof PD. Two new rating scales for opiate withdrawal. Am J Drug Alcohol Abuse 1987; 13(3): 293-308.
13. Akhondzadeh S, Ahmadi-Abhari SA, Assadi SM, Shabestari OL, Kashani AR, Farzanehgan ZM. Double-blind randomized controlled trial of baclofen vs. clonidine in the treatment of opiates withdrawal. J Clin Pharm Ther 2000; 25(5): 347-53.
14. Akhondzadeh S, Kashani L, Mobaseri M, Hosseini SH, Nikzad S, Khani M. Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial. J Clin Pharm Ther 2001; 26(5): 369-73.
15. Assadi SM, Hafezi M, Mokri A, Razzaghi EM, Ghaeli P. Opioid detoxification using high doses of buprenorphine in 24 hours: a randomized, double blind, controlled clinical trial. J Subst Abuse Treat 2004; 27(1): 75-82.
16. Chen SL, Hsu KY, Huang EY, Lu RB, Tao PL. Low doses of dextromethorphan attenuate morphine-induced rewarding via the sigma-1 receptor at ventral tegmental area in rats. Drug Alcohol Depend 2011; 117(2-3): 164-9.
17. Ueda H, Ueda M. Mechanisms underlying morphine analgesic tolerance and dependence. Front Biosci 2009; 14: 5260-72.